SARS-CoV-2 Spike Mutants

Recombinant antigens and lentivirus for emerging SARS-CoV-2 variants

During the course of COVID-19 pandemic, several new SARS-CoV-2 variants have emerged, each with differing mutations that can have impacts on transmissibility, COVID-19 disease severity, and effectiveness of vaccines. AMSBIO now offers a series of recombinant antigens and pseudotyped lentivirus with key Spike mutations in order to evaluate the efficacy of antibodies and vaccines. These products form part of our larger COVID-19 Tools for Research portfolio, including other high quality recombinant proteinsSpike pseudotyped lentivirus, and reagents for vaccine development and evaluation.

Spike Mutant Recombinant Proteins & Assays

B.1.1.7, P.1, and B.1.617.2 and B.1.351 Variants

The B.1.1.7 variant strain (Alpha variant) of SARS-CoV-2 was first discovered in the United Kingdom in late 2020 with an unusually large number of mutations, including a 69/70 deletion and P681H. Following this, the variant has been detected in multiple countries around the world, including the United States, and is associated with increased transmissibility.

In South Africa, another variant of SARS-CoV-2 (Beta variant or B.1.351 lineage) emerged independently of the B.1.1.7 variant. This variant shares some mutations with the B.1.1.7 lineage, but does not contain the deletion at 69/70.

The P.1 variant (Gamma variant) was first identified in Japan, and it has originated in Brazil. This variant has 17 amino acid substitutions, ten of which are in its spike protein, including these three designated to be of particular concern: N501Y, E484K and K417T.

In India, B.1.617.2 or Delta variant has been detected in late 2020. It has mutations in the SARS-CoV-2 spike protein causing the substitutions T478K, P681R and L452R, which are known to affect transmissibility of the virus as well as whether it can be neutralised by antibodies for previously circulating variants of the COVID-19 virus.

We now provide B.1.1.7, P.1, B.1.617.2 , B.1.351 lineages and other variants of interest SARS-CoV-2 Spike recombinant antigens for COVID-19 research.

NamePacksize Order
Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) trimer, His,Avitagâ„¢ (MALS verified)200 ug View
Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) trimer, His,Avitagâ„¢ (MALS verified)25 ug View
Biotinylated SARS-CoV-2 S protein RBD (N501Y), His,Avitagâ„¢ (MALS verified)200 ug View
Biotinylated SARS-CoV-2 S protein RBD (N501Y), His,Avitagâ„¢ (MALS verified)25 ug View
HRP-SARS-CoV-2 Spike RBD (N501Y), His Tag200 ug View
HRP-SARS-CoV-2 Spike RBD (N501Y), His Tag25 ug View
SARS-CoV-2 (COVID-19) S protein RBD (N501Y), His Tag (MALS verified)1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (N501Y), His Tag (MALS verified)100 ug View
SARS-CoV-2 (COVID-19) S1 protein (A570D), His Tag1 mg View
SARS-CoV-2 (COVID-19) S1 protein (A570D), His Tag100 ug View
SARS-CoV-2 (COVID-19) S1 protein (HV69-70del), His Tag1 mg View
SARS-CoV-2 (COVID-19) S1 protein (HV69-70del), His Tag100 ug View
SARS-CoV-2 (COVID-19) S1 protein (N501Y), His Tag1 mg View
SARS-CoV-2 (COVID-19) S1 protein (N501Y), His Tag100 ug View
SARS-CoV-2 (COVID-19) S1 protein (P681H), His Tag1 mg View
SARS-CoV-2 (COVID-19) S1 protein (P681H), His Tag100 ug View
SARS-CoV-2 (COVID-19) S1 protein (Y144del), His Tag1 mg View
SARS-CoV-2 (COVID-19) S1 protein (Y144del), His Tag100 ug View
SARS-CoV-2 S protein RBD (N501Y), Fc Tag (MALS verified)1 mg View
SARS-CoV-2 S protein RBD (N501Y), Fc Tag (MALS verified)100 ug View
SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), Fc Tag1 mg View
SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), Fc Tag100 ug View
SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), His Tag1 mg View
SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), His Tag100 ug View
SARS-CoV-2 S1 protein NTD (HV69-70del, Y144del), His Tag (MALS verified)1 mg View
SARS-CoV-2 S1 protein NTD (HV69-70del, Y144del), His Tag (MALS verified)100 ug View
SARS-CoV-2 S2 protein (T716I, S982A, D1118H), His Tag1 mg View
SARS-CoV-2 S2 protein (T716I, S982A, D1118H), His Tag100 ug View
SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)500 ug View
Spike RBD (B.1.1.7), Avi-His-Tag (SARS-CoV-2)1 mg View
Spike RBD (B.1.1.7), Avi-His-Tag (SARS-CoV-2)100 ug View
Spike S1 (B.1.1.7 Variant), Avi-His-Tag (SARS-CoV-2)1 mg View
Spike S1 (B.1.1.7 Variant), Avi-His-Tag (SARS-CoV-2)100 ug View
Spike Trimer (S1+S2) (B.1.1.7 Variant), His-Tag (SARS-CoV-2)1 mg View
Spike Trimer (S1+S2) (B.1.1.7 Variant), His-Tag (SARS-CoV-2)100 ug View

NamePacksize Order
Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag, Super stable trimer (MALS verified)200 ug View
Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag, Super stable trimer (MALS verified)25 ug View
Biotinylated SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His,Avitagâ„¢ (MALS verified)200 ug View
Biotinylated SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His,Avitagâ„¢ (MALS verified)25 ug View
Biotinylated SARS-CoV-2 S protein RBD (K417N, E484K, N501Y), His,Avitagâ„¢200 ug View
Biotinylated SARS-CoV-2 S protein RBD (K417N, E484K, N501Y), His,Avitagâ„¢25 ug View
HRP-SARS-CoV-2 Spike RBD (K417N, E484K, N501Y), His Tag200 ug View
HRP-SARS-CoV-2 Spike RBD (K417N, E484K, N501Y), His Tag25 ug View
SARS-CoV-2 (COVID-19) S protein RBD (E484K), His Tag (MALS verified)1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (E484K), His Tag (MALS verified)100 ug View
SARS-CoV-2 (COVID-19) S protein RBD (K417N, E484K, N501Y), His Tag (MALS verified)1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (K417N, E484K, N501Y), His Tag (MALS verified)100 ug View
SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified)50 ug View
SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified)500 ug View
SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), His Tag (MALS verified)50 ug View
SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), His Tag (MALS verified)500 ug View
SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His Tag (MALS verified)50 ug View
SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His Tag (MALS verified)500 ug View
SARS-CoV-2 S protein RBD (K417N), His Tag (MALS verified)1 mg View
SARS-CoV-2 S protein RBD (K417N), His Tag (MALS verified)100 ug View
SARS-CoV-2 S protein RBD (K417N, E484K, N501Y), Fc Tag (MALS verified)1 mg View
SARS-CoV-2 S protein RBD (K417N, E484K, N501Y), Fc Tag (MALS verified)100 ug View
SARS-CoV-2 S1 protein (E484K, D614G), His Tag1 mg View
SARS-CoV-2 S1 protein (E484K, D614G), His Tag100 ug View
SARS-CoV-2 S1 protein (L18F, D80A, D215G, LAL242-244del, R246I, K417N, E484K, N501Y, D614G), Fc Tag1 mg View
SARS-CoV-2 S1 protein (L18F, D80A, D215G, LAL242-244del, R246I, K417N, E484K, N501Y, D614G), Fc Tag100 ug View
SARS-CoV-2 S1 protein (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G), His Tag1 mg View
SARS-CoV-2 S1 protein (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G), His Tag100 ug View
SARS-CoV-2 S1 protein NTD (L18F, D80A, D215G, 242-244del, R246I), His Tag (MALS verified)1 mg View
SARS-CoV-2 S1 protein NTD (L18F, D80A, D215G, 242-244del, R246I), His Tag (MALS verified)100 ug View
SARS-CoV-2 S2 protein (A701V), His Tag1 mg View
SARS-CoV-2 S2 protein (A701V), His Tag100 ug View
SARS-CoV-2 Spike RBD (K417N, E484K, N501Y), Mouse IgG1 Fc Tag (MALS verified)1 mg View
SARS-CoV-2 Spike RBD (K417N, E484K, N501Y), Mouse IgG1 Fc Tag (MALS verified)100 ug View
SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)500 ug View
SARS-CoV-2 Spike Trimer (K417N, D614G), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (K417N, D614G), His Tag (MALS verified)500 ug View
SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)500 ug View
Spike RBD (B.1.351) Avi-His-Tag (SARS-CoV-2)1 mg View
Spike RBD (B.1.351) Avi-His-Tag (SARS-CoV-2)100 ug View
Spike S1 (B.1.351), Avi-His-Tag (SARS-CoV-2)1 mg View
Spike S1 (B.1.351), Avi-His-Tag (SARS-CoV-2)100 ug View
Spike Trimer (S1+S2) (B.1.351 Variant), His-Tag (SARS-CoV-2)1 mg View
Spike Trimer (S1+S2) (B.1.351 Variant), His-Tag (SARS-CoV-2)100 ug View
Spike Trimer (S1+S2) (B.1.351 Variant, delta242-244) (SARS-CoV-2)100 ug View

NamePacksize Order
Biotinylated SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) trimer, His,Avitagâ„¢ (MALS verified)200 ug View
Biotinylated SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) trimer, His,Avitagâ„¢ (MALS verified)25 ug View
Biotinylated SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His,Avitagâ„¢200 ug View
Biotinylated SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His,Avitagâ„¢25 ug View
SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)50 ug View
SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)500 ug View
SARS-CoV-2 S protein RBD (K417T), His Tag (MALS verified)1 mg View
SARS-CoV-2 S protein RBD (K417T), His Tag (MALS verified)100 ug View
SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), Fc Tag (MALS verified)1 mg View
SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), Fc Tag (MALS verified)100 ug View
SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His Tag (MALS verified)1 mg View
SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), His Tag (MALS verified)100 ug View
SARS-CoV-2 S1 protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y), Fc Tag1 mg View
SARS-CoV-2 S1 protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y), Fc Tag100 ug View
SARS-CoV-2 S1 protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y), His Tag1 mg View
SARS-CoV-2 S1 protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y), His Tag100 ug View
SARS-CoV-2 S1 protein NTD (L18F, T20N, P26S, D138Y, R190S), His Tag (MALS verified)1 mg View
SARS-CoV-2 S1 protein NTD (L18F, T20N, P26S, D138Y, R190S), His Tag (MALS verified)100 ug View
SARS-CoV-2 S2 protein (T1027I, V1176F), His Tag1 mg View
SARS-CoV-2 S2 protein (T1027I, V1176F), His Tag100 ug View
SARS-CoV-2 Spike RBD (K417T, E484K, N501Y), Mouse IgG1 Fc Tag (MALS verified)1 mg View
SARS-CoV-2 Spike RBD (K417T, E484K, N501Y), Mouse IgG1 Fc Tag (MALS verified)100 ug View
SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)500 ug View
SARS-CoV-2 Spike Trimer (K417T, D614G), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (K417T, D614G), His Tag (MALS verified)500 ug View
SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)500 ug View
Spike S1 (K417T, E484K, N501Y), Avi-His-Tag (SARS-CoV-2)100 ug View
Spike S1 (P.1 Variant), Avi-His-Tag (SARS-CoV-2)100 ug View
Spike S1 RBD (K417T, E484K, N501Y), Avi-His-Tag (SARS-CoV-2)1 mg View
Spike S1 RBD (K417T, E484K, N501Y), Avi-His-Tag (SARS-CoV-2)100 ug View
Spike Trimer (S1+S2) (K417T, E484K, N501Y), His- Tag (SARS-CoV-2)1 mg View
Spike Trimer (S1+S2) (K417T, E484K, N501Y), His- Tag (SARS-CoV-2)100 ug View

NamePacksize Order
HRP-SARS-CoV-2 Spike RBD (L452R, T478K), His Tag200 ug View
HRP-SARS-CoV-2 Spike RBD (L452R, T478K), His Tag25 ug View
HRP-SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag200 ug View
HRP-SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag25 ug View
SARS-CoV-2 Spike RBD (L452R, T478K), Fc Tag (MALS verified)1 mg View
SARS-CoV-2 Spike RBD (L452R, T478K), Fc Tag (MALS verified)100 ug View
SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)50 ug View
SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)500 ug View
Spike S1 (B.1.617.2 Variant) Avi-His-Tag (SARS-CoV-2)1 mg View
Spike S1 (B.1.617.2 Variant) Avi-His-Tag (SARS-CoV-2)100 ug View
Spike S1 RBD (B.1.617.2, Delta Variant), Avi-His-Tag (SARS-CoV-2) HiP™1 mg View
Spike S1 RBD (B.1.617.2, Delta Variant), Avi-His-Tag (SARS-CoV-2) HiP™100 ug View

NameDatasheetPacksize Order
Biotinylated SARS-CoV-2 Spike RBD (K417N, L452R, T478K), His,Avitagâ„¢(MALS verified)-200 ug View
Biotinylated SARS-CoV-2 Spike RBD (K417N, L452R, T478K), His,Avitagâ„¢(MALS verified)-25 ug View
Biotinylated SARS-CoV-2 Spike RBD (L452R), His,Avitagâ„¢ (MALS verified)-200 ug View
Biotinylated SARS-CoV-2 Spike RBD (L452R), His,Avitagâ„¢ (MALS verified)-25 ug View
Biotinylated SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His,Avitagâ„¢ (MALS verified)-200 ug View
Biotinylated SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His,Avitagâ„¢ (MALS verified)-25 ug View
HRP-SARS-CoV-2 Spike RBD (K417N, L452R, T478K), His Tag-200 ug View
HRP-SARS-CoV-2 Spike RBD (K417N, L452R, T478K), His Tag-25 ug View
HRP-SARS-CoV-2 Spike RBD (L452R, E484Q), His Tag-200 ug View
HRP-SARS-CoV-2 Spike RBD (L452R, E484Q), His Tag-25 ug View
SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag-1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag-100 ug View
SARS-CoV-2 (COVID-19) S protein RBD (N440K), His Tag (MALS verified)-1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (N440K), His Tag (MALS verified)-100 ug View
SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag-1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag-100 ug View
SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag-100 ug View
SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag-1 mg View
SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag-100 ug View
SARS-CoV-2 (COVID-19) S1 protein (E583D), His Tag-1 mg View
SARS-CoV-2 (COVID-19) S1 protein (E583D), His Tag-100 ug View
SARS-CoV-2 (COVID-19) S1 protein NTD (A222V), His Tag (MALS verified)-1 mg View
SARS-CoV-2 (COVID-19) S1 protein NTD (A222V), His Tag (MALS verified)-100 ug View
SARS-CoV-2 (COVID-19) S1 protein NTD (N234Q), His Tag-1 mg View
SARS-CoV-2 (COVID-19) S1 protein NTD (N234Q), His Tag-100 ug View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y), His Tag-1 mg View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y), His Tag-100 ug View
SARS-CoV-2 S1 protein NTD (A262S), His Tag (MALS verified)-1 mg View
SARS-CoV-2 S1 protein NTD (A262S), His Tag (MALS verified)-100 ug View
SARS-CoV-2 S1 protein NTD (P272L), His Tag (MALS verified)-1 mg View
SARS-CoV-2 S1 protein NTD (P272L), His Tag (MALS verified)-100 ug View
SARS-CoV-2 Spike RBD (E484K, N501Y), His Tag (MALS verified)-1 mg View
SARS-CoV-2 Spike RBD (E484K, N501Y), His Tag (MALS verified)-100 ug View
SARS-CoV-2 Spike RBD (K417N, L452R, T478K), His Tag (MALS verified)-1 mg View
SARS-CoV-2 Spike RBD (K417N, L452R, T478K), His Tag (MALS verified)-100 ug View
SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)-50 ug View
SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)-500 ug View
SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His Tag (MALS verified)-50 ug View
SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His Tag (MALS verified)-500 ug View
Spike Trimer (S1+S2) (B.1.429 Variant) His-Tag (SARS-CoV-2)-100 ug View

Nucleocapsid Protein Mutants

NamePacksize Order
Nucleocapsid Protein (B.1.1.7 Variant), Avi-His-Tag (SARS-CoV-2)100 ug View
Nucleocapsid Protein (B.1.351 Variant), Avi-His-Tag (SARS-CoV-2)1 mg View
Nucleocapsid Protein (B.1.351 Variant), Avi-His-Tag (SARS-CoV-2)100 ug View
Nucleocapsid Protein (P.1 Variant), Avi-His-Tag (SARS-CoV-2)100 ug View
SARS-CoV-2 Nucleocapsid protein (D3L, R203K, G204R, S235F), His Tag1 mg View
SARS-CoV-2 Nucleocapsid protein (D3L, R203K, G204R, S235F), His Tag100 ug View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y), His Tag1 mg View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y), His Tag100 ug View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y, R385K), His Tag1 mg View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y, R385K), His Tag100 ug View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y), His Tag1 mg View
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y), His Tag100 ug View

Assay Kits

NamePacksize Order
Spike RBD (B.1.1.7 Variant) (N501Y) (SARS-CoV-2): ACE2 Inhibitor Screening Chemiluminescence Assay Kit96 reactions View
Spike RBD (B.1.1.7 Variant) (N501Y) (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit96 reactions View
Spike S1 (B.1.1.7 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Chemiluminescence Assay Kit96 reactions View
Spike S1 (B.1.1.7 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit96 reactions View
Spike S1 RBD (B.1.351 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Chemiluminescence Assay Kit96 reactions View
Spike S1 RBD (B.1.351 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit96 reactions View
Spike Trimer (S1+S2) (B.1.1.7 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit96 reactions View
Spike Trimer (S1+S2) (B.1.351 Variant) (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit96 reactions View

Neutralizing Antibodies

NameDatasheetPacksize Order
Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122)1 mg View
Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122)100 ug View
Spike S1 Neutralizing Antibody (WT, B.1.1.7 and B.1.351 Variant) (Clone C-A11) (SARS-CoV-2)100 ug View

Spike Mutant Pseudotyped Lentivirus

To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase or EGFP reporter, allowing the monitoring of viral entry into host cells.

We provide ready-to-use SARS-CoV-2 Spike Pseudotyped Lentivirus for alpha, beta, gamma, and delta variants and D614G mutation. The D614G  mutation emerged in a variant of SARS-CoV-2 in late January or early February 2020 and was discovered to dramatically increase infectivity of the virus. These lentivirus produced with different SARS-CoV-2 Spike mutants as the envelope glycoproteins instead of the commonly used VSV-G, can be used to measure the activity of neutralizing antibody against SARS-CoV-2 in a Biosafety Level 2 facility. For further information on our other SARS-CoV-2 Spike Pseudotyped Lentiviruses, refer to this page.

NamePacksize Order
Spike (B.1.1.7 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)100 ul View
Spike (B.1.1.7 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)500 ul x 2 View
Spike (B.1.351 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (B.1.351 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)100 ul View
Spike (B.1.351 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)500 ul x 2 View
Spike (B.1.429 Variant) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (B.1.429 Variant) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (B.1.617 Variant) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (B.1.617 Variant) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (B.1.617.1 Variant) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (B.1.617.1 Variant) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (B.1.617.2 Variant) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (B.1.617.2 Variant) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (B.1.617.2.1; Delta Plus Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)100 ul View
Spike (B.1.617.2.1; Delta Plus Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)500 ul x 2 View
Spike (B.1.617.2.1; Delta Plus Variant) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (B.1.617.2.1; Delta Plus Variant) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (B.1.617.2; Delta Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)100 ul View
Spike (B.1.617.2; Delta Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)500 ul x 2 View
Spike (B.1.618 Variant) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (B.1.618 Variant) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (K417T, E484K, N501Y) (SARS-CoV-2) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (K417T, E484K, N501Y) (SARS-CoV-2) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (P.1 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (P.1 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (P.1 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)100 ul View
Spike (P.1 Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)500 ul x 2 View
Spike (SARS-CoV-2, B.1.1.7 Variant) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (SARS-CoV-2, B.1.1.7 Variant) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View
Spike (SARS-CoV-2, D614G) Pseudotyped Lentivirus (Luc Reporter)100 ul View
Spike (SARS-CoV-2, D614G) Pseudotyped Lentivirus (Luc Reporter)500 ul x 2 View