Inflammation, Arthritis, & Allergy

Gain a deeper understanding: Inflammation in wound healing and disease

Inflammation is part of the body’s immune response which occurs following injury or infection. This natural defense mechanism helps eliminate the foreign substances causing damage and initiates the healing process. 

Inflammation is clearly an essential healing mechanism; without it our wounds would remain open and infection would reach dangerous levels. However, sometimes inflammation can be detrimental to health if there is an excessive amount of it. This can happen with arthritis and other autoimmune diseases, where the body’s (which usually fights infection) instead attacks some of the body’s own cells by mistake. 

Allergies are a common cause of inflammation and can be triggered by a variety of substances, such as pollen, dust, and pet dander. When an allergen enters the body, the immune system overreacts and produces antibodies that attack the allergen. This reaction can cause inflammation, swelling, and pain in the joints.

Featured Research

Gut bacteria Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice

  • Dr. Mahesh S. Desai and colleagues from the Department of Infection and Immunity at Luxembourg Institute of Health published a paper revealing that depriving mice of dietary fiber alters the gut microbiome, leading to exacerbated allergic reaction to food allergens. 
  • The alteration in the gut microbiome caused an increase in the mucin-degrading bacterium Akkermansia muciniphila. This was found to be associated with intestinal barrier dysfunction, increased expression of type 1 and 2 cytokines, and IgE-coated commensals in the colon, resulting in an exacerbated allergic reaction to food allergens. 
  • The researchers used mouse anti-ovalbumin IgE monoclonal antibody and mouse anti-ovalbumin IgG1 monoclonal antibody from AMSBIO to conduct allergen-specific ELISA assays. This technique enabled them to quantify the levels of allergen-specific IgE and IgG1 antibodies present in serum samples. 

Citations