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Biorepository
High quality human and animal biospecimens
Exosomes
What are Exosomes?
Exosomes are small endosome derived lipid nanoparticles (30-100 nm in diameter), actively secreted by exocytosis in most living cells. Present in both normal and pathological conditions, their release occurs either constitutively or upon activation.
Where are Exosomes Found?
Exosomes have been isolated from diverse cell lines (hematopoietic cells, tumor lines, primary cultures, and virus infected cells) as well as from biological fluids e.g. serum and plasma from cancer patients, and other body fluids, including bronchoalveolar lavage fluid, pleural effusions, synovial fluid, saliva, and urine.
Functions of Exosomes
Acting on tissues in both the local environment and further afield, exosomes function as signal carriers through their cargo of RNA, proteins, lipids and DNA. Exosomes are involved in a wide range of normal and pathogenic processes including:
- Cell metabolism and signaling
- Inflammation
- Immune responses
- Metastasis and progression of tumors
- Coagulation
- Transfer of proteins & nucleic acids
Our Products
We provide a series of ready-to-use exosome quantification ELISA plates for precise exosome quantification and multiple marker analyses in a number of pathological conditions including inflammation, cancer or neurodegenerative diseases.
Our exosome isolation tools include immunoplates and immunobeads for easy and efficient overall or specific intact exosome isolation from small volumes of biological fluids or cell culture media.
Reagents, immunobeads and immunoplates for highly pure exosome isolation from small volumes of biological fluids or cell media samples. Isolated exosomes are suitable for a wide range of downstream analyses.
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Lyophilized Exosome Standards can be used as positive controls for immunocapture performance evaluation in a number of laboratory techniques, including FACS, Western blotting, and ELISAs. We offer both Exosome Standards from human biological fluids (e.g. plasma, serum, urine) and from cell culture supernatants of a range of human cancer cell lines. The lyophilization enables long-term stability of the exosomes at 4ºC.
We also have a selection of Fluorescent Standards for exosome tracking in fluorescence microscopy experiments. The exosomes are labelled with a stable green dye, providing a long-lasting well visible signal. The exosomes are quantified for overall protein content and particle number and validated by NTA.
With no need to precipitate, concentrate, or desalt before PCR and sequencing, the ExoDNA™ Extraction Kit allows exosomal DNA extraction from purified exosomes isolated from biofluids and cell supernatants.
For efficient isolation and extraction of total RNA from variety of samples, use the ExoRNA™ Kit. This kit enables efficient isolation and extraction of high-quality total RNA.
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