Spike Trimer (S1+S2) (B.1.351|Beta Variant|?242-244) (SARS-CoV-2) Recombinant

Recombinant SARS-CoV-2 Spike protein in its homotrimeric form|containing S1+S2 subunits and encompassing amino acids 16-1213. This protein corresponds to SARS-CoV-2 Variant B.1.351|also known as variant Beta originally discovered in South Africa|and contains the nine known mutations listed below|in addition to deletion 242-244. It also contains mutations 682RRAR685>A|K986P and V987P. The construct has a C-terminal His-tag (6xHis). Note that the expected MW of the S1+S2 monomer is 137kDa but migrates at a higher MW in SDS-PAGE due to glycosylation. The recombinant protein was affinity purified.

*Deletion 242-244 is known as 241-243 in some databases and on the CDC website. This is the same deletion. As stated by Tegally et al.|Nature 2021: We also observe a deletion of three amino acids at positions 242 to 244|which was seen in samples extracted and generated in different laboratories across the NGS-SA. This region is difficult to align; the deletion could potentially also be located at positions 241 to 243|but the resulting sequence would be exactly the same.

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