SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)
Product Code
AMS.SPN-C52He-500ug
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SARS-CoV-2 Spike Trimer, His Tag (SPN-C52He) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The mutations (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N) were identified in the SARS-CoV-2 Delta variant (Pango lineage: B.1.617.2; other names: 21A/S:478K). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the N-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
SKU | AMS.SPN-C52He-500ug |
---|---|
Size | 500 ug |
Species | Virus, SARS-CoV-2 |
Expression Host | HEK293 |
Gene symbol | Spike protein |
Tag | His |
Accession No | QHD43416.1 |
Gene synonyms | Spike,S protein,Spike glycoprotein,S glycoprotein |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |