SARS-CoV-2 and COVID-19

Tools to advance your coronavirus research

Coronaviruses are a group of enveloped positive-stranded RNA viruses, containing four structural proteins: spike (S) glycoprotein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein. Spike glycoprotein is a key surface protein of coronaviruses, mediating the entrance of the virus to cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2).

Six strains of coronaviruses (CoVs) that can infect humans had previously been identified until last year. HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoVHKU1 are not highly pathogenic and only cause mild respiratory diseases. SARS-CoV and MERS-CoV have caused two large-scale pandemics. Before efficient antiviral drugs or vaccines were developed for SARS-CoV or MERS-CoV, a new coronavirus was discovered in Wuhan, China.

What is SARS-CoV-2?

SARS-CoV-2, previously known as 2019 novel coronavirus/2019-nCoV, emerged in Wuhan around November 2019 causing an outbreak of disease named COVID-19. With infections spread globally, SARS-CoV-2 was declared a pandemic outbreak by the World Health Organization (WHO) on 11 March 2020. The development of vaccines, diagnostics, and therapeutics is vital for the ongoing control of the outbreak. We provide an ever-expanding collection of tools for SARS-CoV-2 and Coronavirus research, including recombinant proteins, antibodies, inhibitor screening kits, and other assay kits.

Lentivirus for SARS-CoV-2 Research

We have recently launched a set of lentiviruses for SARS-CoV-2 and COVID-19 research. We offer ACE2 lentivirus alongside SARS-CoV-2 Spike pseudotyped lentivirus, and bald lentiviral pseudovirion with additional new lentiviruses for studying cell signalling pathways. We also provide a custom lentivirus service so we can produce lentivirus fully tailored to your research needs.

SARS-CoV-2 Recombinant Proteins and Antibodies

AMSBIO offers an extensive range of high quality recombinant proteins and antibodies for tailored for SARS-CoV-2 and COVID-19 research. Our range of recombinant proteins and antibodies cover research for ACE2, N protein and Spike protein, including the RBD, S1 and S2 subunits.

Magnetic Beads and Pre-Coated Plates

Our new pre-coupled magnetic beads and antigen pre-coated plates offer a more efficient method of capturing anti-SARS-CoV-2 antibodies and ACE2 protein for biopanning, flow cytometry and a range of other applications.

SARS-CoV-2 / COVID-19 Detection Kits

We offer a series of easy-to-use, high quality kits for detection of SARS-CoV-2 and SARS-CoV-2 antibodies in a range of samples. These tools are ideal for a range of applications including epidemiology studies, SARS-CoV-2 screening for research, and determination of previous SARS-CoV-2 infection.

Reagents for SARS-CoV-2 Diagnostic Kit Development

We provide a series of well-established anti-SARS-CoV-2 antibodies, including matched antibody pairs with high sensitivity and affinity, optimized for diagnostic kit development. Alongside these antibodies, we also offer antigens designed for SARS-CoV-2 antibody detection. These are both customizable and available in bulk quantities

COVID-19 Antibody & Antigen Titer Assay Kits

This series of high quality antibody and antigen titer assay kits can be used for COVID-19 vaccine development and evaluation, as well as determining SARS-CoV-2 viral infection. The assay kits provide excellent performance, having been developed using high quality proteins with high specificity, sensitivity and reproducibility. Currently, we provide kits for IgG/M antibody detection, neutralizing antibody detection, and nucleocapsid protein antigen titer detection

Customer Spotlight: Heparan Sulfate in COVID-19 infection

HS is emerging as a key factor in infection by the SARS-CoV-2 virus. The JM403 Heparan Sulfate antibody from AMSBIO has been used in two novel assays developed and applied by Prof. Dr. Johan van der Vlag and colleagues at the Radboud University Medical Center, Nijmegen, Netherlands.  The results showed that the JM403 antibody is a powerful tool to develop assays to measure plasma heparanase and HS levels in patients with COVID-19.

SARS-CoV-2 Spike Mutants

During the course of COVID-19 pandemic, several new SARS-CoV-2 variants have emerged, each with differing mutations that can have impacts on transmissibility, COVID-19 disease severity, and effectiveness of vaccines. AMSBIO now offers a series of recombinant antigens and pseudotyped lentivirus with key Spike mutations in order to evaluate the efficacy of antibodies and vaccines.

We offer a series of inhibitor screening kits facilitating the identification and characterization of SARS-CoV-2 inhibitors.

NameDatasheetPacksize Order
3CL Protease (SARS-CoV-2) Assay Kit-96 reactions View
3CL Protease Assay Buffer-25 ml View
ACE2 Inhibitor Screening Assay Kit-96 reactions View
ACE2:SARS-CoV-2 Spike S1-Biotin Inhibitor Screening Assay Kit-96 reactions View
ACE2:Spike RBD (SARS-CoV-2) Inhibitor Screening Assay Kit-96 reactions View
Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit-100 assays View
SARS-CoV-2 (COVID-19) Inhibitor screening Kit-480 tests View
SARS-CoV-2 (COVID-19) Inhibitor screening Kit96 tests View
SARS-CoV-2 IgG Detection Kit (Colorimetric Anti-Spike RBD IgG detection)-96 reactions View
SARS-CoV-2 IgG Detection Kit (Colorimetric Trimer Anti-Spike IgG detection)-96 reactions View
SARS-CoV-2 Spike Trimer (S1+S2):ACE2 Inhibitor Screening Colorimetric Assay Kit-96 reactions View
Spike RBD (SARS-CoV-2):ACE2 Inhibitor Screening Assay Kit-96 reactions View
Spike S1 (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit-96 reactions View
Spike S1-Biotin (SARS-CoV-2): ACE2 TR-FRET Assay Kit-384 reactions View

We offer a number of nucleic acid extraction kits for viruses, including the MagSi-NA Pathogens Kit. This kit enables easy extraction of DNA and RNA from serum, plasma, oropharyngeal swab/nasopharyngeal swab, and any other respiratory samples for pathogen detection. It utilizes magnetic beads to ensure a consistently high yield of DNA and RNA and is suitable for use with various enzymatic down-steam applications, including qPCR and qRT-PCR isothermal amplification.

NameDatasheetPacksize Order
MagSi-NA Pathogens10 x 96 preps View
MagSi-NA Pathogens96 preps View

We provide a series of ready-to-use ORF clones for SARS-CoV-2 genes. These are cloned in different expression vectors with a variety of tags, with some ORF sequences codon-optimized for human cell expression and some containing native virus gene sequences. If you require an ORF cloned into a different vector or need a different viral gene sequence (mutant or fragment), contact us about our custom service.

NameDatasheetPacksize Order
CD147 (BSG) (NM_001728) Human Untagged Clone-10 ug View
CD147 (BSG) (NM_198589) Human Tagged ORF Clone-10 ug View
CD147 (BSG) (NM_198589) Human Untagged Clone-10 ug View
CD147 (BSG) (NM_198590) Human Tagged ORF Clone-10 ug View
CD147 (BSG) (NM_198590) Human Untagged Clone-10 ug View
CD147 (BSG) (NM_198591) Human Tagged ORF Clone-10 ug View
CD147 (BSG) (NM_198591) Human Untagged Clone-10 ug View
FURIN (NM_001289823) Human Tagged ORF Clone-10 ug View
FURIN (NM_001289823) Human Untagged Clone-10 ug View
FURIN (NM_001289824) Human Tagged ORF Clone-10 ug View
FURIN (NM_001289824) Human Untagged Clone-10 ug View
FURIN (NM_002569) Human Tagged ORF Clone-10 ug View
FURIN (NM_002569) Human Untagged Clone-10 ug View
Furin (NM_001081454) Mouse Tagged ORF Clone-10 ug View
Furin (NM_001081454) Mouse Untagged Clone-10 ug View
Furin (NM_011046) Mouse Tagged ORF Clone-10 ug View
Furin (NM_011046) Mouse Untagged Clone-10 ug View
Furin (NM_019331) Rat Tagged ORF Clone-10 ug View
Furin (NM_019331) Rat Untagged Clone-10 ug View
MASP2 (NM_006610) Human Tagged ORF Clone-10 ug View
MASP2 (NM_006610) Human Untagged Clone10 ug View
MASP2 (NM_139208) Human Untagged Clone10 ug View
MagSi-NA Pathogens10 x 96 preps View
MagSi-NA Pathogens96 preps View
Masp2 (NM_001003893) Mouse Tagged ORF Clone-10 ug View
Masp2 (NM_001003893) Mouse Untagged Clone-10 ug View
Masp2 (NM_010767) Mouse Tagged ORF Clone-10 ug View
ORF Plasmid pENTER-CMV-ACE2-600 ul View
SARS-CoV-2 E Gene Tagged ORF (codon optimized)-10 ug View
SARS-CoV-2 E Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 E Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 M Gene Tagged ORF (codon optimized)-10 ug View
SARS-CoV-2 M Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 M Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 N Gene Tagged ORF (codon optimized)-10 ug View
SARS-CoV-2 N Gene Tagged ORF Clone-10 ug View
SARS-CoV-2 N Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp10 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp14 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp4 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp5 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp6 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp7 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp8 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Nsp9 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF10 Gene Tagged ORF (codon optimized)-10 ug View
SARS-CoV-2 ORF10 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF10 Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF3a Gene Tagged ORF (codon optimized)10 ug View
SARS-CoV-2 ORF3a Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF6 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF6 Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF7a Gene Tagged ORF (codon optimized)-10 ug View
SARS-CoV-2 ORF7a Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF7a Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF8 Gene Tagged ORF (codon optimized)10 ug View
SARS-CoV-2 ORF8 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 ORF8 Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 Orf10 Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Orf3a Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Orf9b Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 Orf9c Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 S Gene Tagged ORF (codon optimized)-10 ug View
SARS-CoV-2 S Gene Tagged ORF Clone (Native Sequence)-10 ug View
SARS-CoV-2 S Gene cDNA Clone (Native Sequence)-10 ug View
SARS-CoV-2 S Gene extracellular domain Tagged ORF Clone-10 ug View
TMPRSS2 (NM_001135099) Human Tagged ORF Clone-10 ug View
TMPRSS2 (NM_001135099) Human Untagged Clone-10 ug View
TMPRSS2 (NM_005656) Human Tagged ORF Clone-10 ug View
TMPRSS2 (NM_005656) Human Untagged Clone-10 ug View
Tmprss2 (NM_015775) Mouse Tagged ORF Clone-10 ug View
Tmprss2 (NM_015775) Mouse Untagged Clone-10 ug View
Tmprss2 (NM_130424) Rat Tagged ORF Clone-10 ug View
Tmprss2 (NM_130424) Rat Untagged Clone-10 ug View

We provide CRISPR Knock-Out Kits for both ACE2 and Transmembrane Serine Protease 2 (TMPRSS2). It has been recently shown that SARS-CoV-2 needs both ACE2 and TMPRSS2 for protein priming to enter the cell, making TMPRSS2 a potential drug target.

NamePacksize Order
ACE2 Human Gene Knockout Kit (CRISPR) (Angiotensin Converting Enzyme 2)1 kit View
Ace2 Mouse Gene Knockout Kit (CRISPR)1 kit View
FURIN Human Gene Knockout Kit (CRISPR)1 kit View
Furin Mouse Gene Knockout Kit (CRISPR)1 kit View
MASP2 Human Gene Knockout Kit (CRISPR)1 kit View
Masp2 Mouse Gene Knockout Kit (CRISPR)1 kit View
TMPRSS2 Human Gene Knockout Kit (CRISPR)1 kit View
Tmprss2 Mouse Gene Knockout Kit (CRISPR)1 kit View

We provide a number of shRNA constructs for ACE2 in a variety of vectors.

NameDatasheetPacksize Order
ACE2 Human shRNA Lentiviral Particle (Locus ID 59272)-4 x 0.5 ml View
ACE2 Human shRNA Plasmid Kit (Locus ID 59272)-5 ug/vial View
Ace2 Mouse shRNA Lentiviral Particle (Locus ID 70008)4 x 0.5 ml View
Ace2 Mouse shRNA Plasmid (Locus ID 70008)-5 ug/vial View
Ace2 Mouse siRNA Oligo Duplex (Locus ID 70008)-2 nmol View
Ace2 Rat shRNA Lentiviral Particle (Locus ID 302668)-4 x 0.5 ml View
Ace2 Rat shRNA Plasmid (Locus ID 302668)-5 ug/vial View
Ace2 Rat siRNA Oligo Duplex (Locus ID 302668)-2 nmol View
Angiotensin Converting Enzyme 2 (ACE2) Human siRNA Oligo Duplex (Locus ID 59272)-2 nmol View
BSG Human shRNA Lentiviral Particle (Locus ID 682)4 x 0.5 ml View
BSG Human shRNA Plasmid Kit (Locus ID 682)-5 ug/vial View
Bsg Mouse shRNA Lentiviral Particle (Locus ID 12215)-4 x 0.5 ml View
Bsg Mouse shRNA Plasmid (Locus ID 12215)-5 ug/vial View
Bsg Mouse siRNA Oligo Duplex (Locus ID 12215)-2 nmol View
Bsg Rat shRNA Lentiviral Particle (Locus ID 25246)-4 x 0.5 ml View
Bsg Rat shRNA Plasmid (Locus ID 25246)-5 ug/vial View
Bsg Rat siRNA Oligo Duplex (Locus ID 25246)-2 nmol View
FURIN Human shRNA Lentiviral Particle (Locus ID 5045)-4 x 0.5 ml View
FURIN Human shRNA Plasmid Kit (Locus ID 5045)-5 ug/vial View
FURIN Human siRNA Oligo Duplex (Locus ID 5045)-2 nmol View
Four pre-designed shRNA vectors pAV-ACE2-shRNA-5 ug View
Furin Mouse shRNA Lentiviral Particle (Locus ID 18550)-4 x 0.5 ml View
Furin Mouse shRNA Plasmid (Locus ID 18550)-5 ug/vial View
Furin Mouse siRNA Oligo Duplex (Locus ID 18550)-2 nmol View
Furin Rat shRNA Lentiviral Particle (Locus ID 54281)-4 x 0.5 ml View
Furin Rat shRNA Plasmid (Locus ID 54281)-5 ug/vial View
Furin Rat siRNA Oligo Duplex (Locus ID 54281)-2 nmol View
MASP2 Human shRNA Lentiviral Particle (Locus ID 10747)-4 x 0.5 ml View
MASP2 Human siRNA Oligo Duplex (Locus ID 10747)-2 nmol View
Masp2 Mouse shRNA Lentiviral Particle (Locus ID 17175)-4 x 0.5 ml View
Masp2 Mouse shRNA Plasmid (Locus ID 17175)-5 ug/vial View
Masp2 Mouse siRNA Oligo Duplex (Locus ID 17175)-2 nmol View
Masp2 Rat shRNA Lentiviral Particle (Locus ID 64459)-4 x 0.5 ml View
Masp2 Rat shRNA Plasmid (Locus ID 64459)-5 ug/vial View
Masp2 Rat siRNA Oligo Duplex (Locus ID 64459)-2 nmol View
TMPRSS2 Human shRNA Lentiviral Particle (Locus ID 7113)-4 x 0.5 ml View
TMPRSS2 Human shRNA Plasmid Kit (Locus ID 7113)-5 ug/vial View
TMPRSS2 Human siRNA Oligo Duplex (Locus ID 7113)-2 nmol View
Tmprss2 Mouse shRNA Lentiviral Particle (Locus ID 50528)-4 x 0.5 ml View
Tmprss2 Mouse shRNA Plasmid (Locus ID 50528)-5 ug/vial View
Tmprss2 Mouse siRNA Oligo Duplex (Locus ID 50528)-2 nmol View
Tmprss2 Rat shRNA Lentiviral Particle (Locus ID 156435)-4 x 0.5 ml View
Tmprss2 Rat shRNA Plasmid (Locus ID 156435)-5 ug/vial View

NameDatasheetPacksize Order
ACE2 (Human) ELISA Kit100 assays View
ACE2 - CHO Recombinant Cell Line-2 vials View
ACE2 - HEK293 Recombinant Cell Line-2 vials View
ACE2 - HeLa Recombinant Cell Line-2 vials View
ACE2 Human qPCR Primer Pair (NM_021804) (Angiotensin Converting Enzyme 2)-200 reactions View
ACE2 Human qPCR Template Standard (NM_021804) (Angiotensin Converting Enzyme 2)-1 kit View
Ace2 Mouse qPCR Primer Pair (NM_001130513)-200 reactions View
Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric)100 assays View
Coronavirus IgM/IgG Antibody Detection Card25 tests View
Coronavirus Rapid RT-qPCR Detection Kit100 reactions View
D-(+)-Trehalose Dihydrate, M.B. Grade1 kg View
D-(+)-Trehalose Dihydrate, M.B. Grade-10 g View
D-(+)-Trehalose Dihydrate, M.B. Grade-250 g View
D-(+)-Trehalose Dihydrate, M.B. Grade-5 kg View
D-(+)-Trehalose Dihydrate, M.B. Grade-50 g View
D-(+)-Trehalose Dihydrate, M.B. Grade500 g View
D-(+)-Trehalose Solution, 1M100 ml View
D-(+)-Trehalose Solution, 1M500 ml View
FURIN (NM_002569) Human 3' UTR Clone-10 ug View
FURIN (NM_002569) Human Mass Spec Standard-10 ug View
FURIN (NM_002569) Human Over-expression Lysate100 ug View
FURIN (NM_002569) Human Over-expression Lysate-20 ug View
FURIN Human qPCR Primer Pair (NM_002569)-200 reactions View
FURIN Human qPCR Template Standard (NM_002569)-1 kit View
Furin Mouse qPCR Primer Pair (NM_001081454)-200 reactions View
Furin Mouse qPCR Template Standard (NM_001081454)-1 kit View
Human ACE2 ELISA Kit-1 x 96 wells View
Human ACE2 activation kit by CRISPRa (Angiotensin Converting Enzyme 2)-1 kit View
Human Anti-SARS-CoV-2 (N Protein) IgG ELISA Kit (1x96 Wells)-1 x 96 wells View
Human Anti-SARS-CoV-2 (RBD+M Protein) IgG ELISA Kit (1x96 Wells)1 x 96 wells View
Human CD147 (BSG) activation kit by CRISPRa-1 kit View
Human FURIN activation kit by CRISPRa-1 kit View
Human Furin ELISA Kit-1 x 96 wells View
Human MASP2 activation kit by CRISPRa-1 kit View
Human TMPRSS2 activation kit by CRISPRa1 kit View
MASP2 (NM_006610) Human 3' UTR Clone-10 ug View
MASP2 (NM_139208) Human 3' UTR Clone-10 ug View
MASP2 (NM_139208) Human Over-expression Lysate-100 ug View
MASP2 (NM_139208) Human Over-expression Lysate-20 ug View
MASP2 Human qPCR Primer Pair (NM_006610)-200 reactions View
MASP2 Human qPCR Template Standard (NM_139208)-1 kit View
Masp2 Mouse qPCR Primer Pair (NM_001003893)-200 reactions View
Masp2 Mouse qPCR Template Standard (NM_001003893)-1 kit View
Mouse ACE2 ELISA Kit-1 x 96 wells View
Mouse Ace2 activation kit by CRISPRa-1 kit View
Mouse Bsg activation kit by CRISPRa-1 kit View
Mouse Furin activation kit by CRISPRa-1 kit View
Mouse Masp2 activation kit by CRISPRa-1 kit View
SARS-CoV-2 (COVID-19) N protein gene qPCR Template Standard-1 kit View
SARS-CoV-2 (COVID-19) RdRp qPCR Template Standard-1 kit View
SARS-CoV-2 (COVID-19) S protein gene qPCR Template Standard-1 kit View
SARS-CoV-2 (COVID-19) qPCR Primer Pair N protein-200 reactions View
SARS-CoV-2 (COVID-19) qPCR Primer Pair RdRp-200 reactions View
SARS-CoV-2 (COVID-19) qPCR Primer Pair S protein-200 reactions View
SARS-CoV-2 N Protein (NC_045512) Virus Over-expression Lysate-100 ug View
SARS-CoV-2 N Protein (NC_045512) Virus Over-expression Lysate-20 ug View
SARS-CoV-2 Nucleoprotein IgG Antibody ELISA Kit-96 assays View
TMPRSS2 (NM_001135099) Human 3' UTR Clone-10 ug View
TMPRSS2 (NM_005656) Human 3' UTR Clone-10 ug View
TMPRSS2 (NM_005656) Human Over-expression Lysate-100 ug View
TMPRSS2 (NM_005656) Human Over-expression Lysate-20 ug View
TMPRSS2 Human qPCR Primer Pair (NM_005656)-200 reactions View
TMPRSS2 Human qPCR Template Standard (NM_005656)-1 kit View
Tmprss2 Mouse qPCR Primer Pair (NM_015775)-200 reactions View
Tmprss2 Mouse qPCR Template Standard (NM_015775)-1 kit View