Six strains of coronaviruses (CoVs) that can infect humans had previously been identified until last year. HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoVHKU1 are not highly pathogenic and only cause mild respiratory diseases. SARS-CoV and MERS-CoV have caused two large-scale pandemics. Before efficient antiviral drugs or vaccines were developed for SARS-CoV or MERS-CoV, a new coronavirus was discovered in Wuhan, China.
What is SARS-CoV-2?
SARS-CoV-2, previously known as 2019 novel coronavirus/2019-nCoV, emerged in Wuhan around November 2019 causing an outbreak of disease named COVID-19. With infections spread globally, SARS-CoV-2 was declared a pandemic outbreak by the World Health Organization (WHO) on 11 March 2020. The development of vaccines, diagnostics, and therapeutics is vital for the ongoing control of the outbreak. We provide an ever-expanding collection of tools for SARS-CoV-2 and Coronavirus research, including recombinant proteins, antibodies, inhibitor screening kits, and other assay kits.
Lentivirus for SARS-CoV-2 Research
We have recently launched a set of lentiviruses for SARS-CoV-2 and COVID-19 research. We offer ACE2 lentivirus alongside SARS-CoV-2 Spike pseudotyped lentivirus, and bald lentiviral pseudovirion with additional new lentiviruses for studying cell signalling pathways. We also provide a custom lentivirus service so we can produce lentivirus fully tailored to your research needs.
SARS-CoV-2 Recombinant Proteins and Antibodies
AMSBIO offers an extensive range of high quality recombinant proteins and antibodies for tailored for SARS-CoV-2 and COVID-19 research. Our range of recombinant proteins and antibodies cover research for ACE2, N protein and Spike protein, including the RBD, S1 and S2 subunits.
Magnetic Beads and Pre-Coated Plates
Our new pre-coupled magnetic beads and antigen pre-coated plates offer a more efficient method of capturing anti-SARS-CoV-2 antibodies and ACE2 protein for biopanning, flow cytometry and a range of other applications.
SARS-CoV-2 / COVID-19 Detection Kits
We offer a series of easy-to-use, high quality kits for detection of SARS-CoV-2 and SARS-CoV-2 antibodies in a range of samples. These tools are ideal for a range of applications including epidemiology studies, SARS-CoV-2 screening for research, and determination of previous SARS-CoV-2 infection.
Reagents for SARS-CoV-2 Diagnostic Kit Development
We provide a series of well-established anti-SARS-CoV-2 antibodies, including matched antibody pairs with high sensitivity and affinity, optimized for diagnostic kit development. Alongside these antibodies, we also offer antigens designed for SARS-CoV-2 antibody detection. These are both customizable and available in bulk quantities
COVID-19 Antibody & Antigen Titer Assay Kits
This series of high quality antibody and antigen titer assay kits can be used for COVID-19 vaccine development and evaluation, as well as determining SARS-CoV-2 viral infection. The assay kits provide excellent performance, having been developed using high quality proteins with high specificity, sensitivity and reproducibility. Currently, we provide kits for IgG/M antibody detection, neutralizing antibody detection, and nucleocapsid protein antigen titer detection
Customer Spotlight: Heparan Sulfate in COVID-19 infection
HS is emerging as a key factor in infection by the SARS-CoV-2 virus. The JM403 Heparan Sulfate antibody from AMSBIO has been used in two novel assays developed and applied by Prof. Dr. Johan van der Vlag and colleagues at the Radboud University Medical Center, Nijmegen, Netherlands. The results showed that the JM403 antibody is a powerful tool to develop assays to measure plasma heparanase and HS levels in patients with COVID-19.
SARS-CoV-2 Spike Mutants
During the course of COVID-19 pandemic, several new SARS-CoV-2 variants have emerged, each with differing mutations that can have impacts on transmissibility, COVID-19 disease severity, and effectiveness of vaccines. AMSBIO now offers a series of recombinant antigens and pseudotyped lentivirus with key Spike mutations in order to evaluate the efficacy of antibodies and vaccines.
Spike (SARS-CoV-2) pseudotyped VSV delta G particles
SARS-CoV-2 Spike VSV Delta G represents a robust model to study the mechanisms of SARS-CoV-2 interaction with ACE2 (Angiotensin converting enzyme 2), to characterize neutralizing antibodies, and to screen or titrate drugs that prevent viral entry into human cells. It is the preferred pseudovirus to study SARS-CoV-2 infection of Vero-6 and Calu-3 cells.
Kits Products
We offer a series of inhibitor screening kits facilitating the identification and characterization of SARS-CoV-2 inhibitors.
Name | Datasheet | Packsize | Order |
---|---|---|---|
3CL Protease Assay Buffer | - | 25 ml | View |
3CL Protease|MBP-tagged (SARS-CoV-2) Assay Kit | - | 96 reactions | View |
ACE2 Inhibitor Screening Assay Kit | 96 reactions | View | |
ACE2: Spike S1 RBD (SARS-CoV-2) Inhibitor Screening Assay Kit | - | 96 reactions | View |
ACE2: Spike S1-Biotin (SARS-CoV-2 ) Inhibitor Screening Assay Kit | - | 96 reactions | View |
SARS-CoV-2 (COVID-19) Inhibitor screening Kit | - | 480 tests | View |
SARS-CoV-2 IgG Detection Kit (Colorimetric Anti-Spike S1 RBD IgG detection) | - | 96 reactions | View |
SARS-CoV-2 IgG Detection Kit (Colorimetric Trimer Anti-Spike IgG detection) | - | 96 reactions | View |
SARS-CoV-2 Spike Trimer (S1+S2):ACE2 Inhibitor Screening Colorimetric Assay Kit | - | 96 reactions | View |
Spike S1 (SARS-CoV-2): ACE2 Inhibitor Screening Colorimetric Assay Kit | - | 96 reactions | View |
Spike S1 RBD (SARS-CoV-2): ACE2 Inhibitor Screening Assay Kit | - | 96 reactions | View |
Spike S1-Biotin (SARS-CoV-2): ACE2 TR-FRET Assay Kit | - | 384 reactions | View |
We offer a number of nucleic acid extraction kits for viruses, including the <a href="https://www.amsbio.com/magsi-na-pathogens-kit/">MagSi-NA Pathogens Kit</a>. This kit enables easy extraction of DNA and RNA from serum, plasma, oropharyngeal swab/nasopharyngeal swab, and any other respiratory samples for pathogen detection. It utilizes magnetic beads to ensure a consistently high yield of DNA and RNA and is suitable for use with various enzymatic down-steam applications, including qPCR and qRT-PCR isothermal amplification.
We provide a series of ready-to-use ORF clones for SARS-CoV-2 genes. These are cloned in different expression vectors with a variety of tags, with some ORF sequences codon-optimized for human cell expression and some containing native virus gene sequences. If you require an ORF cloned into a different vector or need a different viral gene sequence (mutant or fragment), contact us about our custom service.
Name | Datasheet | Packsize | Order |
---|---|---|---|
CD147 (BSG) (NM_001728) Human Untagged Clone | - | 10 µg | View |
CD147 (BSG) (NM_198589) Human Tagged ORF Clone | - | 10 µg | View |
CD147 (BSG) (NM_198589) Human Untagged Clone | - | 10 µg | View |
CD147 (BSG) (NM_198590) Human Tagged ORF Clone | - | 10 µg | View |
CD147 (BSG) (NM_198590) Human Untagged Clone | - | 10 µg | View |
CD147 (BSG) (NM_198591) Human Tagged ORF Clone | - | 10 µg | View |
CD147 (BSG) (NM_198591) Human Untagged Clone | - | 10 µg | View |
FURIN (NM_001289823) Human Tagged ORF Clone | - | 10 µg | View |
FURIN (NM_001289823) Human Untagged Clone | - | 10 µg | View |
FURIN (NM_001289824) Human Tagged ORF Clone | - | 10 µg | View |
FURIN (NM_001289824) Human Untagged Clone | - | 10 µg | View |
FURIN (NM_002569) Human Tagged ORF Clone | - | 10 µg | View |
FURIN (NM_002569) Human Untagged Clone | - | 10 µg | View |
Furin (NM_001081454) Mouse Tagged ORF Clone | - | 10 ug | View |
Furin (NM_001081454) Mouse Untagged Clone | - | 10 ug | View |
Furin (NM_011046) Mouse Tagged ORF Clone | - | 10 ug | View |
Furin (NM_011046) Mouse Untagged Clone | - | 10 ug | View |
Furin (NM_019331) Rat Tagged ORF Clone | - | 10 ug | View |
Furin (NM_019331) Rat Untagged Clone | - | 10 ug | View |
MASP2 (NM_006610) Human Tagged ORF Clone | - | 10 µg | View |
MASP2 (NM_006610) Human Untagged Clone | 10 µg | View | |
MASP2 (NM_139208) Human Untagged Clone | 10 µg | View | |
MagSi-NA Pathogens | 10x96 preps | View | |
MagSi-NA Pathogens | 96 preps | View | |
Masp2 (NM_001003893) Mouse Tagged ORF Clone | - | 10 ug | View |
Masp2 (NM_001003893) Mouse Untagged Clone | - | 10 ug | View |
Masp2 (NM_010767) Mouse Tagged ORF Clone | - | 10 ug | View |
SARS-CoV-2 E Gene Tagged ORF (codon optimized) | - | 10 µg | View |
SARS-CoV-2 E Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 E Gene cDNA Clone (Native Sequence) | - | 10 ug | View |
SARS-CoV-2 M Gene Tagged ORF (codon optimized) | - | 10 µg | View |
SARS-CoV-2 M Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 M Gene cDNA Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 N Gene Tagged ORF (codon optimized) | - | 10 µg | View |
SARS-CoV-2 N Gene Tagged ORF Clone | - | 10 µg | View |
SARS-CoV-2 N Gene cDNA Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp10 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp14 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp4 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp5 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp6 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp7 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp8 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Nsp9 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF10 Gene Tagged ORF (codon optimized) | - | 10 µg | View |
SARS-CoV-2 ORF10 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF10 Gene cDNA Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF3a Gene Tagged ORF (codon optimized) | 10 µg | View | |
SARS-CoV-2 ORF3a Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF6 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF6 Gene cDNA Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF7a Gene Tagged ORF (codon optimized) | - | 10 µg | View |
SARS-CoV-2 ORF7a Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF7a Gene cDNA Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF8 Gene Tagged ORF (codon optimized) | 10 µg | View | |
SARS-CoV-2 ORF8 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 ORF8 Gene cDNA Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Orf10 Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Orf3a Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Orf9b Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 Orf9c Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 S Gene Tagged ORF (codon optimized) | - | 10 µg | View |
SARS-CoV-2 S Gene Tagged ORF Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 S Gene cDNA Clone (Native Sequence) | - | 10 µg | View |
SARS-CoV-2 S Gene extracellular domain Tagged ORF Clone | - | 10 µg | View |
TMPRSS2 (NM_001135099) Human Tagged ORF Clone | - | 10 µg | View |
TMPRSS2 (NM_001135099) Human Untagged Clone | - | 10 µg | View |
TMPRSS2 (NM_005656) Human Tagged ORF Clone | - | 10 µg | View |
TMPRSS2 (NM_005656) Human Untagged Clone | - | 10 µg | View |
Tmprss2 (NM_015775) Mouse Tagged ORF Clone | - | 10 ug | View |
Tmprss2 (NM_015775) Mouse Untagged Clone | - | 10 ug | View |
Tmprss2 (NM_130424) Rat Tagged ORF Clone | - | 10 ug | View |
Tmprss2 (NM_130424) Rat Untagged Clone | - | 10 ug | View |
We provide CRISPR Knock-Out Kits for both ACE2 and Transmembrane Serine Protease 2 (TMPRSS2). It has been recently shown that SARS-CoV-2 needs both ACE2 and TMPRSS2 for protein priming to enter the cell, making TMPRSS2 a potential drug target.
Name | Packsize | Order |
---|---|---|
ACE2 Human Gene Knockout Kit (CRISPR) (Angiotensin Converting Enzyme 2) | 1 kit | View |
Ace2 Mouse Gene Knockout Kit (CRISPR) | 1 kit | View |
FURIN Human Gene Knockout Kit (CRISPR) | 1 kit | View |
Furin Mouse Gene Knockout Kit (CRISPR) | 1 kit | View |
MASP2 Human Gene Knockout Kit (CRISPR) | 1 kit | View |
Masp2 Mouse Gene Knockout Kit (CRISPR) | 1 kit | View |
TMPRSS2 Human Gene Knockout Kit (CRISPR) | 1 kit | View |
Tmprss2 Mouse Gene Knockout Kit (CRISPR) | 1 kit | View |
We provide a number of shRNA constructs for ACE2 in a variety of vectors.
Name | Datasheet | Packsize | Order |
---|---|---|---|
ACE2 Human shRNA Lentiviral Particle (Locus ID 59272) (Angiotensin Converting Enzyme 2) | - | 500 ul each | View |
ACE2 Human shRNA Plasmid Kit (Locus ID 59272) (Angiotensin Converting Enzyme 2) | - | 5 µg/vial | View |
ACE2 Mouse shRNA Plasmid (Locus ID 70008) | - | 5 µg/vial | View |
ACE2 Rat shRNA Plasmid (Locus ID 302668) | - | 5 µg/vial | View |
Ace2 Mouse shRNA Lentiviral Particle (Locus ID 70008) | 500 ul each | View | |
Ace2 Mouse siRNA Oligo Duplex (Locus ID 70008) | - | 2 nmol | View |
Ace2 Rat shRNA Lentiviral Particle (Locus ID 302668) | - | 500 ul each | View |
Ace2 Rat siRNA Oligo Duplex (Locus ID 302668) | - | 2 nmol | View |
Angiotensin Converting Enzyme 2 (ACE2) Human siRNA Oligo Duplex (Locus ID 59272) | - | 2 nmol | View |
Bsg Mouse shRNA Lentiviral Particle (Locus ID 12215) | - | 500 ul each | View |
Bsg Mouse shRNA Plasmid (Locus ID 12215) | - | 5 µg/vial | View |
Bsg Mouse siRNA Oligo Duplex (Locus ID 12215) | - | 2 nmol | View |
Bsg Rat shRNA Lentiviral Particle (Locus ID 25246) | - | 500 ul each | View |
Bsg Rat shRNA Plasmid (Locus ID 25246) | - | 5 µg/vial | View |
Bsg Rat siRNA Oligo Duplex (Locus ID 25246) | - | 2 nmol | View |
CD147 (BSG) Human shRNA Lentiviral Particle (Locus ID 682) | 500 ul each | View | |
CD147 (BSG) Human shRNA Plasmid Kit (Locus ID 682) | - | 5 µg/vial | View |
FURIN Human shRNA Lentiviral Particle (Locus ID 5045) | - | 500 ul each | View |
FURIN Human shRNA Plasmid Kit (Locus ID 5045) | - | 5 µg/vial | View |
FURIN Human siRNA Oligo Duplex (Locus ID 5045) | - | 2 nmol | View |
Furin Mouse shRNA Lentiviral Particle (Locus ID 18550) | - | 500 ul each | View |
Furin Mouse shRNA Plasmid (Locus ID 18550) | - | 5 µg/vial | View |
Furin Rat shRNA Lentiviral Particle (Locus ID 54281) | - | 500 ul each | View |
Furin Rat shRNA Plasmid (Locus ID 54281) | - | 5 µg/vial | View |
Furin Rat siRNA Oligo Duplex (Locus ID 54281) | - | 2 nmol | View |
MASP2 Human shRNA Lentiviral Particle (Locus ID 10747) | - | 500 ul each | View |
MASP2 Human siRNA Oligo Duplex (Locus ID 10747) | - | 2 nmol | View |
Masp2 Mouse shRNA Lentiviral Particle (Locus ID 17175) | - | 500 ul each | View |
Masp2 Mouse shRNA Plasmid (Locus ID 17175) | - | 5 µg/vial | View |
Masp2 Mouse siRNA Oligo Duplex (Locus ID 17175) | - | 2 nmol | View |
Masp2 Rat shRNA Lentiviral Particle (Locus ID 64459) | - | 500 ul each | View |
Masp2 Rat shRNA Plasmid (Locus ID 64459) | - | 5 µg/vial | View |
Masp2 Rat siRNA Oligo Duplex (Locus ID 64459) | - | 2 nmol | View |
TMPRSS2 Human shRNA Lentiviral Particle (Locus ID 7113) | - | 500 ul each | View |
TMPRSS2 Human shRNA Plasmid Kit (Locus ID 7113) | - | 5 µg/vial | View |
TMPRSS2 Human siRNA Oligo Duplex (Locus ID 7113) | - | 2 nmol | View |
Tmprss2 Mouse shRNA Lentiviral Particle (Locus ID 50528) | - | 500 ul each | View |
Tmprss2 Mouse shRNA Plasmid (Locus ID 50528) | - | 5 µg/vial | View |
Tmprss2 Mouse siRNA Oligo Duplex (Locus ID 50528) | - | 2 nmol | View |
Tmprss2 Rat shRNA Lentiviral Particle (Locus ID 156435) | - | 500 ul each | View |
Tmprss2 Rat shRNA Plasmid (Locus ID 156435) | - | 5 µg/vial | View |
Name | Datasheet | Packsize | Order |
---|---|---|---|
ACE2 - CHO Recombinant Cell Line | - | 2 vials | View |
ACE2 - HEK293 Recombinant Cell Line | - | 2 vials | View |
ACE2 - HeLa Recombinant Cell Line | - | 2 vials | View |
ACE2 Human qPCR Primer Pair (NM_021804) (Angiotensin Converting Enzyme 2) | - | 200 reactions | View |
ACE2 Human qPCR Template Standard (NM_021804) (Angiotensin Converting Enzyme 2) | - | 1 kit | View |
Ace2 Mouse qPCR Primer Pair (NM_001130513) | - | 200 reactions | View |
D-(+)-Trehalose Dihydrate| M.B. Grade | 500g | View | |
D-(+)-Trehalose Dihydrate|M.B. Grade | 1 kg | View | |
D-(+)-Trehalose Solution| 1M | 100ml | View | |
D-(+)-Trehalose Solution| 1M | 500ml | View | |
FURIN (NM_002569) Human 3' UTR Clone | - | 10 µg | View |
FURIN (NM_002569) Human Mass Spec Standard | - | 10 ug | View |
FURIN (NM_002569) Human Over-expression Lysate | 100 ug | View | |
FURIN (NM_002569) Human Over-expression Lysate | - | 20 ug | View |
FURIN Human qPCR Primer Pair (NM_002569) | - | 200 reactions | View |
FURIN Human qPCR Template Standard (NM_002569) | - | 1 kit | View |
Furin Mouse qPCR Primer Pair (NM_001081454) | - | 200 reactions | View |
Furin Mouse qPCR Template Standard (NM_001081454) | - | 1 kit | View |
Human ACE2 activation kit by CRISPRa (Angiotensin Converting Enzyme 2) | - | 1 kit | View |
Human Anti-SARS-CoV-2 (N Protein) IgG ELISA Kit (1x96 Wells) | - | 1 x 96 wells | View |
Human Anti-SARS-CoV-2 (RBD+M Protein) IgG ELISA Kit (1x96 Wells) | 1 x 96 wells | View | |
Human CD147 (BSG) activation kit by CRISPRa | - | 1 kit | View |
Human FURIN activation kit by CRISPRa | - | 1 kit | View |
Human Furin ELISA Kit | - | 1 x 96 wells | View |
Human MASP2 activation kit by CRISPRa | - | 1 kit | View |
Human TMPRSS2 activation kit by CRISPRa | 1 kit | View | |
MASP2 (NM_006610) Human 3' UTR Clone | - | 10 µg | View |
MASP2 (NM_139208) Human 3' UTR Clone | - | 10 µg | View |
MASP2 (NM_139208) Human Over-expression Lysate | - | 100 ug | View |
MASP2 (NM_139208) Human Over-expression Lysate | - | 20 ug | View |
MASP2 Human qPCR Primer Pair (NM_006610) | - | 200 reactions | View |
MASP2 Human qPCR Template Standard (NM_139208) | - | 1 kit | View |
Masp2 Mouse qPCR Primer Pair (NM_001003893) | - | 200 reactions | View |
Masp2 Mouse qPCR Template Standard (NM_001003893) | - | 1 kit | View |
Mouse ACE2 ELISA Kit | - | 1 x 96 wells | View |
Mouse Ace2 activation kit by CRISPRa | - | 1 kit | View |
Mouse Bsg activation kit by CRISPRa | - | 1 kit | View |
Mouse Furin activation kit by CRISPRa | - | 1 kit | View |
Mouse Masp2 activation kit by CRISPRa | - | 1 kit | View |
SARS-CoV-2 (COVID-19) N protein gene qPCR Template Standard | - | 1 kit | View |
SARS-CoV-2 (COVID-19) RdRp qPCR Template Standard | - | 1 kit | View |
SARS-CoV-2 (COVID-19) S protein gene qPCR Template Standard | - | 1 kit | View |
SARS-CoV-2 (COVID-19) qPCR Primer Pair N protein | - | 200 reactions | View |
SARS-CoV-2 (COVID-19) qPCR Primer Pair RdRp | - | 200 reactions | View |
SARS-CoV-2 (COVID-19) qPCR Primer Pair S protein | - | 200 reactions | View |
SARS-CoV-2 N Protein (NC_045512) Virus Over-expression Lysate | - | 100 ug | View |
SARS-CoV-2 N Protein (NC_045512) Virus Over-expression Lysate | - | 20 ug | View |
TMPRSS2 (NM_001135099) Human 3' UTR Clone | - | 10 µg | View |
TMPRSS2 (NM_005656) Human 3' UTR Clone | - | 10 µg | View |
TMPRSS2 (NM_005656) Human Over-expression Lysate | - | 100 ug | View |
TMPRSS2 (NM_005656) Human Over-expression Lysate | - | 20 ug | View |
TMPRSS2 Human qPCR Primer Pair (NM_005656) | - | 200 reactions | View |
TMPRSS2 Human qPCR Template Standard (NM_005656) | - | 1 kit | View |
Tmprss2 Mouse qPCR Primer Pair (NM_015775) | - | 200 reactions | View |
Tmprss2 Mouse qPCR Template Standard (NM_015775) | - | 1 kit | View |