Chondroitin Sulfate Proteoglycans (CSPGs) are involved in the inhibition of axon regeneration after various forms of damage to the Central Nervous System, including stroke and spinal cord injury. The enzyme Chondroitinase ABC (purified from Proteus vulgaris) degrades these CSPGs, and has been shown to promote functional recovery and neural regeneration in addition to its role as a tool in glycoanalysis.

Chondroitin Sulfate/Dermatan Sulfate

Explore CS and DS Chains

Chondroitin Sulfate (CS) and Dermatan Sulfate (DS) are linear anionic polysaccharides that are widely found on the cell surface and in the cell matrix and connective tissue. CS and DS chains are usually attached to core proteins, forming proteoglycans (PGs). CS and DS exhibit different sulfation patterns and variable sequence arrangements, and their molecular weights also vary within a large range, increasing the structural complexity and diversity of CS/DS. The structure and function of CS/DS PGs involves them in a variety of physiological and pathological processes.

For more on Chondroitin Sulfate and Dermatan Sulfate, see our pages on Purified Glycosaminoglycans, Chondroitin Sulfate Antibodies and Chondroitinase Enzymes. See also our Glycobiology home page.

Chondroitin Sulfate & Dermatan Sulfate Structural Variation

  • The only structural difference between Chondroitin Sulfate and Dermatan Sulfate is related to the presence of IdoA in the latter.
  • Both types of GAG chains are extensively sulfated by 4-O and 6-O sulfation on GalNAc and 2-O sulfation on GlcA and IdoA.
  • The pattern of sulfation can be determined after digestion with bacterial chondroitinases.
  • These enzymes release the disaccharide GlcA/IdoA(b1-3) GalNAc with different sulfation patterns.
  • The major types of sulfated polysaccharides are defined by the letters A to E.
  • These variations in sulfation patterns confer different roles to CSs by promoting selective interactions with different molecules.

Structural Variability of Chondroitin Sulfate & Dermatan Sulfate

AMSBIO is proud to support the glycobiology / Proteoglycan research community with a suite of products for the different sulfation patterns of Chondroitin Sulfate and Dermatan Sulfate.

Letter identificationDermatan Sulfate
(formerly Chondroitin Sulfate B)
Sulfate A
Chondroitin Sulfate CChondroitin Sulfate DChondroitin Sulfate E
Site of sulfationVariousCarbon 4 of N-acetylgalactosamine (GalNAc) sugarCarbon 6 of the GalNAc sugarCarbon 2 of glucuronic acid and 6 of GalNAc sugarCarbons 4 and 6 of GalNAc sugar
Systematic nameDSC-4-SC-6-SC-2,6-SC-4,6-S
AMSBIO Antibody Offering
Monoclonal antibodies recognising undigested GAG:2H6, LY111, CS-562H6, LY111, CS-56MO-225
CS Stub Antibodies recognizing 0S,4S,6S2B6 (after digestion with Chondroitinase B)2B63B3
Enzyme Activity against different classes / sulfation patterns.Chondroitinase BChondroitinase AC Enzymes (Flavo, Arthro)
Chondroitinase ABC catalyses the removal of CS and DS side chains of CSPGs with some activity against HA.
AMSBIO Carbohydrate Offering
OligosaccharidesYesYes (CS-AC oligos)YesNot Yet

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