Chondroitin Sulfate Proteoglycans (CSPGs) are involved in the inhibition of axon regeneration after various forms of damage to the Central Nervous System, including stroke and spinal cord injury. The enzyme Chondroitinase ABC (purified from Proteus vulgaris) degrades these CSPGs, and has been shown to promote functional recovery and neural regeneration in addition to its role as a tool in glycoanalysis.

Chondroitin Sulfate Antibodies

Chondroitin Sulfate Monoclonal & Polyclonal Antibodies

Chondroitin sulfate (CS) is a sulfated glycosaminoglycan made up of repeating disaccharide units. In cartilage, CS is found as linear polysaccharide chains that are covalently attached to the core protein of proteoglycans. We offer a wide range of CS monoclonal and polyclonal antibodies that are tested for use in ELISA, Immunofluorescence, Immunohistochemistry, Radioimmunoassay, and Western Blotting assays.

What We Offer

Along with our Chondroitinase ABC, we also supply three monoclonal chondroitin sulfate stub antibodies that recognise unsulfated (0S)4-sulfated (4S) & 6-sulfated (6S) Chondroitin & Dermatan Sulfate containing proteoglycans, following Chondroitinase ABC digestion of proteoglycans or perineuronal nets.

Features

  • There is no cross-reaction with hyaluronic acid, dermatan sulfate, keratan sulfate or heparan sulfate.
  • These antibodies can be used to detect target antigen in Immunohistochemistry, ELISA, and Western blotting assays.

Chondroitin Sulfate Monoclonal Antibodies

Chondroitin sulfate polysaccharides are involved in various cellular events in the formation, regeneration, and maintenance of the neural network. A range of purified mouse monoclonal chondroitin sulfate antibodies are available to native (undigested) CS: clone: MO-225, clone: CS-56, Clone: 2H6, and clone: LY111, each uniquely recognizing a validated epitope, allowing the end-user to analyse biologically significant variations in CS structure.

Anti-CS-AC

(Clone: CS-56)

The mAb (clone: CS-56) recognizes chondroitin sulphate containing CSPG, only types A and C in bovine mammary gland epithelial (BMGE) cells and in human, chicken and mouse fibroblasts or tissues.

Anti-Chondroitin Sulfate A

(Clone: 2H6)

The mAb (clone: 2H6) recognizes effectively chondroitin sulfate A, especially the glycosaminoglycan existing in the developing central nervous system.

Anti-Chondroitin Sulfate A

(Clone: LY111)

The mAb (clone: LY111) preferentially recognizes chondroitin sulfate containing the GlcUAβ1-3GalNAc(4S) disaccharide unit (A-unit).

Anti-Chondroitin Sulfate D

(Clone: MO-225)

The mAb (clone: MO-225) preferentially recognizes chondroitin sulfate containing the GlcUA(2-O-sulfate) β1-3GalNAc(6-O-sulfate) disaccharide unit (D-unit).

Chondroitin Sulfate Polyclonal Antibodies

We also provide three polyclonal antibodies for Chondroitin sulfate proteoglycan 4 (CSPG4). These antibodies recognize CSPG4 in immunohistochemical staining and western blotting.

NamePacksize Order
Human Polyclonal Antibody FOR Chondroitin sulfate proteoglycan 440 ug / 0.2 ml View
Mouse Polyclonal Antibody FOR Chondroitin sulfate proteoglycan 440 ug / 0.2 ml View
Rat Polyclonal Antibody FOR Chondroitin sulfate proteoglycan 440 ug / 0.2 ml View

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