Enzymatic degradation for Chondroitin Sulfate/ Dermatan Sulfate
The biological activity of chondroitinase enzymes are due to their ability to act on chondroitin (CS) and dermatan (DS) sulfate chains of chondroitin sulfate proteoglycans (CSPGs). CSPGs are needed for normal functioning of the body; with increases or decreases in the level of CSPGs associated with various pathological conditions. Chondroitinase ABC from Proteus vulgaris can be useful in conditions where there is an increase in the level of CSPGs, namely spinal cord injury, vitreous attachment, and cancer. Over the last decade, various animal studies have shown that chondroitinase ABC could be a good drug candidate. AMSBIO provides chondroitinase ABC (purified from Proteus vulgaris), as well as chondroitinase ACI and chondroitinase B (both from Flavobacterium heparinum). These offer targeted digestion of different sulfation patterns of CS / DS.
What We Offer
- EC Number 184.108.40.206
- Purified from Proteus vulgaris
- Degrades polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to oligosaccharide, mainly disaccharides.
- Catalyzes chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate
- Acts slowly on hyaluronate.
- Purified from Flavobacterium heparinum
- Degrades only dermatan sulfate (chondroitin sulphate B) producing oligo- and tetra-saccharides, and an unsaturated 4-sulphated disaccharide.
- Major linkage cleaved: GalNAc,4S 1-4 IdoA