Chondroitinase

Enzymatic degradation for Chondroitin Sulfate/ Dermatan Sulfate

The biological activity of chondroitinase enzymes are due to their ability to act on chondroitin (CS) and dermatan (DS) sulfate chains of chondroitin sulfate proteoglycans (CSPGs). CSPGs are needed for normal functioning of the body; with increases or decreases in the level of CSPGs associated with various pathological conditions. Chondroitinase ABC from Proteus vulgaris can be useful in conditions where there is an increase in the level of CSPGs, namely spinal cord injury, vitreous attachment, and cancer. Over the last decade, various animal studies have shown that chondroitinase ABC could be a good drug candidate. AMSBIO provides chondroitinase ABC (purified from Proteus vulgaris), as well as chondroitinase ACI and chondroitinase B (both from Flavobacterium heparinum). These offer targeted digestion of different sulfation patterns of CS / DS.

What We Offer

Chondroitinase ABC

  • EC Number 4.2.2.4
  • Purified from Proteus vulgaris
  • Degrades polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to oligosaccharide, mainly disaccharides.
  • Catalyzes chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate
  • Acts slowly on hyaluronate.

NameDatasheetPacksize Order
Chondroitinase ABC (Proteus vulgaris)10 units View
Chondroitinase ABC Protease Free (Proteus vulgaris)2 units View
Chondroitinase ABC protease free (lyophilized) 2U/vial2 units View

Chondroitinase B

  • Purified from Flavobacterium heparinum
  • Degrades only dermatan sulfate (chondroitin sulphate B) producing oligo- and tetra-saccharides, and an unsaturated 4-sulphated disaccharide.
  • Major linkage cleaved: GalNAc,4S 1-4 IdoA

NameDatasheetPacksize Order
Chondroitinase B from Flavobacterium heparinum, 2 IU2 IU View
Chondroitinase B from Flavobacterium heparinum, 5 IU5 IU View
Chondroitinase B from Recombinant Flavobacterium heparinum - Research Grade5 ug View