ACE2: Spike S1-Biotin (SARS-CoV-2 ) Inhibitor Screening Assay Kit
Product Code
AMS.79945
$0.00
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Coronavirus disease 2019 (COVID-19) increases the risk of developing Acute Respiratory Distress Syndrome (ARDS)|which is often fatal at the late stages of the infection when the SAR-CoV-2 virus causes significant damage to the lungs. As a first step of the viral replication strategy|the virus attaches to the host cell surface before entering the cell. The Spike S1 protein recognizes and attaches to the Angiotensin Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes|endothelial cells|and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike S1 protein of SARS-CoV-2 and ACE2 may offer some protection against the viral infection.
The ACE2:SARS-CoV-2 Spike S1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this interaction. The key to this kit is the high sensitivity of detection of Spike S1-Biotin protein by Streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First|ACE2 protein is attached to a nickel-coated 96-well plate. Next|SARS-CoV-2 Spike S1-Biotin is incubated with ACE2 on the plate. Finally|the plate is treated with Streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence|which then can be measured using a chemiluminescence reader.
The ACE2:SARS-CoV-2 Spike S1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this interaction. The key to this kit is the high sensitivity of detection of Spike S1-Biotin protein by Streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First|ACE2 protein is attached to a nickel-coated 96-well plate. Next|SARS-CoV-2 Spike S1-Biotin is incubated with ACE2 on the plate. Finally|the plate is treated with Streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence|which then can be measured using a chemiluminescence reader.
SKU | AMS.79945 |
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Size | 96 reactions |
Application | This kit is useful for screening for inhibitors of ACE2 binding to SARS-CoV-2 Spike S1. |
Species reactivity | SARS-CoV-2 |
Gene synonyms | Coronavirus, nCoV-2019, nCoV2019, ACEH Screening kit, SARS spike ELISA, ACEH ELISA |
Storage | Up to 6 months from date of receipt# when stored as recommended. |
Shipping Temp | -80C (dry ice) |
Supplier Name | BPS |