Reagents and kits for PGs Research

Proteoglycans (PGs) are glycosylated proteins which have covalently attached highly anionic glycosaminoglycans (GAGs). We provide our extensive range of PGs products including (Antibodies - Recombinant Proteins - Kits - CytoSections) for glycobiology research.


Heparan Sulfate Proteoglycans

Heparan sulfate proteoglycans (HSPGs) are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. HSPGs are glycoproteins, with the common characteristic of containing one or more covalently attached heparan sulfate (HS) chains, a type of glycosaminoglycan (GAG). Cells elaborate a relatively small set of HSPGs (~17) that fall into three groups according to their location: membrane HSPGs, such as syndecans and glycosylphosphatidylinositol-anchored proteoglycans (glypicans), the secreted extracellular matrix HSPGs (agrin, perlecan, type XVIII collagen), and the secretory vesicle proteoglycan, serglycin. HS is evolutionarily ancient, and its composition has remained relatively constant from Hydra to humans (see Table 1).

The postulated functions of HSPG include cell proliferation, differentiation, adhesion, migration, and morphogenesis. We offer a range of products including (Antibodies - Recombinant Proteins - Kits - CytoSections) for research on HSPGs as follows:

ProteoglycanCore Protein (kDa)Number & Type of GAG chainsGene
Perlecan4001–3 HS, 0–2 CSHSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2Expand Products
Betaglycan110110 0–1 HS, 0–1 CSTGFBR3Expand Products
Agrin2001–3 HSAGRNExpand Products
Syndecan 131–451–3 HS, 0–2 CSSDC1Expand Products
Syndecan 231–451–3 HS, 0–2 CSSDC2Expand Products
Syndecan 331–451–3 HS, 0–2 CSSDC3Expand Products
Syndecan 431–451–3 HS, 0–2 CSSDC4Expand Products
Testican 160HSSPOCK1 Expand Products
Testican 260HSSPOCK2Expand Products
Testican 360HSSPOCK3
Decorin361 CS/DSDCNExpand Products
Biglycan380–2 CS/DSBGNExpand Products
Serglycin10–1910–15 heparin/CSSRGNExpand Products
Glypican 1∼601–3 HSGPC1Expand Products
Glypican 2∼601–3 HSGPC2Expand Products
Glypican 3∼601–3 HSGPC3Expand Products
Glypican 4∼601–3 HSGPC4Expand Products
Glypican 5∼601–3 HSGPC5Expand Products
Glypican 6∼601–3 HSGPC6Expand Products

Chondroitin Sulfate Proteoglycans

Chondroitin sulfate proteoglycans (CSPGs) consist of a protein core on which there are one or more serine residues that can act as the sites of attachment of glycan chains. They are used as barrier-forming molecules in many biological events. Various observations lead to the conclusion that they are important inhibitory molecules in the reactive glial tissue surrounding injuries. Several CSPGs, including neurocan, phosphacan, versican and aggrecan (see Table 2) are upregulated in CNS scar tissue, all of which can inhibit axon regeneration. Therefore, Chondroitinase ABC enzyme (purified from Proteus vulgaris) degrades these CSPGs and has been shown to promote functional recovery and neural regeneration in addition to its role as a tool in glycoanalysis.

We offer a range of products including (Antibodies - Recombinant Proteins - Kits - CytoSections) for research on CSPGs as follows:

ProteoglycanCore Protein (kDa)Number & Type of GAG chainsGene
Aggrecan (GSPG1)208–220∼100 CS, ∼20 KS II
(human, bovine)
ACANExpand Products
Versican (GSPG2)265 (50–450
kDa splice forms)
0–15 CS/DSVCANExpand Products
Neurocan (GSPG3)1451–2 CS/DSNCANExpand Products
Neuroglycan (GSPG5)120CSCSPG5Expand Products
Brevican (CSPG7)960–4 CS/DSBCANExpand Products
Phosphacan1752–5 CS/DSPTPRZ1Expand Products
BikuninAMBPExpand Products
CD44 (CSPG8)370–2 CS/DS/HSCD44Expand Products
CSPG4 (melanoma-associated chondroitin sulfate proteoglycan, NG2)2512–3 CS/DSCSPG4Expand Products
SMC3 (CSPG6, structural maintenance of chromosomes 3)SMC3Expand Products

Keratan Sulfate Proteoglycans

Keratan sulfate proteoglycans (KSPGs) play a pivotal role in the development and maintenance of corneal transparency. Keratocan, lumican, and mimecan (osteoglycin) are the major KSPGs in vertebrate corneas (see Table 3).

We offer a range of products including (Antibodies - Recombinant Proteins - Kits - CytoSections) for research on KSPGs as follows:

ProteoglycanCore Protein (kDa)Number & Type of GAG chainsGene
Lumican373–4 KS ILUMExpand Products
Keratocan373–4 KS IKERAExpand Products
Mimecan/ Osteoglycin252–3 KS IOGNExpand Products
Fibromodulin592–4 KS IFMODExpand Products
Osteoadherin/ Osteomodulin47KSOMDExpand Products
Prolargin/PRELPPRELPExpand Products