WHAT WE OFFER?
Heparan Sulfate Proteoglycans
Heparan sulfate proteoglycans (HSPGs) are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. HSPGs are glycoproteins, with the common characteristic of containing one or more covalently attached heparan sulfate (HS) chains, a type of glycosaminoglycan (GAG). Cells elaborate a relatively small set of HSPGs (~17) that fall into three groups according to their location: membrane HSPGs, such as syndecans and glycosylphosphatidylinositol-anchored proteoglycans (glypicans), the secreted extracellular matrix HSPGs (agrin, perlecan, type XVIII collagen), and the secretory vesicle proteoglycan, serglycin. HS is evolutionarily ancient, and its composition has remained relatively constant from Hydra to humans (see Table 1).
The postulated functions of HSPG include cell proliferation, differentiation, adhesion, migration, and morphogenesis. We offer a range of products including (Antibodies - Recombinant Proteins - Kits - CytoSections) for research on HSPGs as follows:
| Proteoglycan | Core Protein (kDa) | Number & Type of GAG chains | Gene | |
|---|---|---|---|---|
| Perlecan | 400 | 1–3 HS, 0–2 CS | HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2 | Expand Products |
| Betaglycan | 110 | 110 0–1 HS, 0–1 CS | TGFBR3 | Expand Products |
| Agrin | 200 | 1–3 HS | AGRN | Expand Products |
| Syndecan 1 | 31–45 | 1–3 HS, 0–2 CS | SDC1 | Expand Products |
| Syndecan 2 | 31–45 | 1–3 HS, 0–2 CS | SDC2 | Expand Products |
| Syndecan 3 | 31–45 | 1–3 HS, 0–2 CS | SDC3 | Expand Products |
| Syndecan 4 | 31–45 | 1–3 HS, 0–2 CS | SDC4 | Expand Products |
| Testican 1 | 60 | HS | SPOCK1 | Expand Products |
| Testican 2 | 60 | HS | SPOCK2 | Expand Products |
| Testican 3 | 60 | HS | SPOCK3 | |
| Decorin | 36 | 1 CS/DS | DCN | Expand Products |
| Biglycan | 38 | 0–2 CS/DS | BGN | Expand Products |
| Serglycin | 10–19 | 10–15 heparin/CS | SRGN | Expand Products |
| Glypican 1 | ∼60 | 1–3 HS | GPC1 | Expand Products |
| Glypican 2 | ∼60 | 1–3 HS | GPC2 | Expand Products |
| Glypican 3 | ∼60 | 1–3 HS | GPC3 | Expand Products |
| Glypican 4 | ∼60 | 1–3 HS | GPC4 | Expand Products |
| Glypican 5 | ∼60 | 1–3 HS | GPC5 | Expand Products |
| Glypican 6 | ∼60 | 1–3 HS | GPC6 | Expand Products |
Chondroitin Sulfate Proteoglycans
Chondroitin sulfate proteoglycans (CSPGs) consist of a protein core on which there are one or more serine residues that can act as the sites of attachment of glycan chains. They are used as barrier-forming molecules in many biological events. Various observations lead to the conclusion that they are important inhibitory molecules in the reactive glial tissue surrounding injuries. Several CSPGs, including neurocan, phosphacan, versican and aggrecan (see Table 2) are upregulated in CNS scar tissue, all of which can inhibit axon regeneration. Therefore, Chondroitinase ABC enzyme (purified from Proteus vulgaris) degrades these CSPGs and has been shown to promote functional recovery and neural regeneration in addition to its role as a tool in glycoanalysis.
We offer a range of products including (Antibodies - Recombinant Proteins - Kits - CytoSections) for research on CSPGs as follows:
| Proteoglycan | Core Protein (kDa) | Number & Type of GAG chains | Gene | |
|---|---|---|---|---|
| Aggrecan (GSPG1) | 208–220 | ∼100 CS, ∼20 KS II (human, bovine) | ACAN | Expand Products |
| Versican (GSPG2) | 265 (50–450 kDa splice forms) | 0–15 CS/DS | VCAN | Expand Products |
| Neurocan (GSPG3) | 145 | 1–2 CS/DS | NCAN | Expand Products |
| Neuroglycan (GSPG5) | 120 | CS | CSPG5 | Expand Products |
| Brevican (CSPG7) | 96 | 0–4 CS/DS | BCAN | Expand Products |
| Phosphacan | 175 | 2–5 CS/DS | PTPRZ1 | Expand Products |
| Bikunin | AMBP | Expand Products | ||
| CD44 (CSPG8) | 37 | 0–2 CS/DS/HS | CD44 | Expand Products |
| CSPG4 (melanoma-associated chondroitin sulfate proteoglycan, NG2) | 251 | 2–3 CS/DS | CSPG4 | Expand Products |
| SMC3 (CSPG6, structural maintenance of chromosomes 3) | SMC3 | Expand Products | ||
Keratan Sulfate Proteoglycans
Keratan sulfate proteoglycans (KSPGs) play a pivotal role in the development and maintenance of corneal transparency. Keratocan, lumican, and mimecan (osteoglycin) are the major KSPGs in vertebrate corneas (see Table 3).
We offer a range of products including (Antibodies - Recombinant Proteins - Kits - CytoSections) for research on KSPGs as follows:
| Proteoglycan | Core Protein (kDa) | Number & Type of GAG chains | Gene | |
|---|---|---|---|---|
| Lumican | 37 | 3–4 KS I | LUM | Expand Products |
| Keratocan | 37 | 3–4 KS I | KERA | Expand Products |
| Mimecan/ Osteoglycin | 25 | 2–3 KS I | OGN | Expand Products |
| Fibromodulin | 59 | 2–4 KS I | FMOD | Expand Products |
| Osteoadherin/ Osteomodulin | 47 | KS | OMD | Expand Products |
| Prolargin/PRELP | PRELP | Expand Products | ||
