Collagen-Induced Arthritis

Highly purified cartilage collagen for inducing arthritis

Collagen-induced arthritis (CIA) is a condition induced in mice or rats and is the most common autoimmune model used to study rheumatoid arthritis. CIA shares both immunological and pathological features with human rheumatoid arthritis, therefore it is used extensively as a model to study the pathogenesis of the disease and for testing therapeutics.

CIA can be induced in rodents and non-human primates by immunization with type II collagen emulsified with adjuvant. It has been reported that type XI collagen is also capable of inducing arthritis in mice and rats, due to the alpha 3 chain of type XI collagen being identical to the alpha 1 chain of type II collagen.

Collagen

Incomplete and Complete Freund's Adjuvant for CIA

NameDatasheetPacksize Order
Complete Freund's Adjuvant, 1 mg/ml1 mg/ml x 5 ml View
Complete Freund's Adjuvant, 10 mg/ml10 mg/ml x 5 ml View
Complete Freund's Adjuvant, 2 mg/ml-2 mg/ml x 5 ml View
Complete Freund's Adjuvant, 20 mg/ml20 mg/ml x 5 ml View
Complete Freund's Adjuvant, 3 mg/ml3 mg/ml x 5 ml View
Complete Freund's Adjuvant, 4 mg/ml4 mg/ml x 5 ml View
Complete Freund's Adjuvant, 5 mg/ml5 mg/ml x 5 ml View
Immunization Grade Chick Type XI Collagen, 5 mg, lyophilized5 mg View
Immunization Grade Human Type XI Collagen, 1 mg, lyophilized1 mg View
Immunization Grade Porcine Type XI Collagen, 5 mg, lyophilized-5 mg View
Incomplete Freund's Adjuvant5 ml View

Using Animal Models: Factors to Consider

The genetic background of mice, even in the same strain, will vary from vendor to vendor and can affect how the animals respond to various reagents, thus impacting the results of your experiment. Therefore, testing animals from different vendors using a defined protocol is recommended before proceeding with a large full-scale experiment.

The bacteria flora is very important to the health of the animal, including the proper functioning of the immune system. Therefore, we recommend housing animals in Specific Pathogen Free (SPF) conditions rather than conventional conditions to avoid variability caused by bacteria.