Highly purified collagen induced arthritis
Collagen-induced arthritis (CIA) is a condition induced in mice or rats and is the most common autoimmune model used to study rheumatoid arthritis. CIA shares both immunological and pathological features with human rheumatoid arthritis, therefore it is used extensively as a model to study the pathogenesis of the disease and for testing therapeutics.
CIA can be induced in rodents and non-human primates by immunization with type II collagen emulsified with adjuvant. It has been reported that type XI collagen is also capable of inducing arthritis in mice and rats, due to the alpha 3 chain of type XI collagen being identical to the alpha 1 chain of type II collagen.
Incomplete and Complete Freund's Adjuvant for CIA
|Complete Freund's Adjuvant, 1 mg/ml||1 mg/ml x 5 ml||View|
|Complete Freund's Adjuvant, 10 mg/ml||10 mg/ml x 5 ml||View|
|Complete Freund's Adjuvant, 2 mg/ml||-||2 mg/ml x 5 ml||View|
|Complete Freund's Adjuvant, 20 mg/ml||20 mg/ml x 5 ml||View|
|Complete Freund's Adjuvant, 3 mg/ml||3 mg/ml x 5 ml||View|
|Complete Freund's Adjuvant, 4 mg/ml||4 mg/ml x 5 ml||View|
|Complete Freund's Adjuvant, 5 mg/ml||5 mg/ml x 5 ml||View|
|Immunization Grade Chick Type XI Collagen, 5 mg, lyophilized||5 mg||View|
|Immunization Grade Human Type XI Collagen, 1 mg, lyophilized||1 mg||View|
|Immunization Grade Porcine Type XI Collagen, 5 mg, lyophilized||-||5 mg||View|
|Incomplete Freund's Adjuvant||5 ml||View|
Using Animal Models: Factors to Consider
The genetic background of mice, even in the same strain, will vary from vendor to vendor and can affect how the animals respond to various reagents, thus impacting the results of your experiment. Therefore, testing animals from different vendors using a defined protocol is recommended before proceeding with a large full-scale experiment.
The bacteria flora is very important to the health of the animal, including the proper functioning of the immune system. Therefore, we recommend housing animals in Specific Pathogen Free (SPF) conditions rather than conventional conditions to avoid variability caused by bacteria.