Spike (SARS-CoV-2) Pseudotyped Lentivirus (Luciferase Reporter)

Product Code
Shipping Information
Product Updates
  • Keep up to date with product offers, resources and news

  • Sign up

The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection.; The SARS-CoV-2 Spike Pseudotyped Lentivirus were produced with SARS-CoV-2 Spike (Genbank Accession #QHD43416.1) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions also contain the firefly luciferase gene driven by a CMV promoter, therefore, the spike-mediated cell entry can be conveniently measured via luciferase reporter activity. The SARS-CoV-2 Spike pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 in a Biosafety Level 2 facility.;
More Information
SKU AMS.79942-2
Size 500 ul x 2
Species SARS-CoV-2
Application 1. Study the mechanism of viral transduction. 2. Screening for neutralizing antibodies for SARS-CoV-2 Spike and ACE2.
Gene synonyms coronavirus, covid, covid-19, covid19, Sars-cov-2, sars cov 2, sarscov2
Storage Lentiviruses are shipped with dry ice. For long term storage, it is recommended to store the virus at -80C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle
Shipping Temp -80C
Supplier Name BPS
For more details visit our Lentiviruses for SARS-CoV-2 & COVID-19 Research page >