Important cosignaling pathways in immune regulation

The checkpoint receptors HVEM, LIGHT, and BTLA are part of a complex network of overlapping receptor interactions that function in both immune stimulation and suppression.

AMSBIO supplies a wide range of HVEM products for use in immuno-oncology research including recombinant HVEM, LIGHT, and BTLA proteins, BTLA:HVEM and LIGHT:HVEM Inhibitor Screening Assay Kits, and HVEM and LIGHT-expressing cell lines.

HVEM in Cancer

HVEM has also become an important immuno-oncology target after researchers discovered that HVEM is involved in the induction of apoptosis of tumor cells.

When HVEM interacts with a protein known as LIGHT (TNFSF14, CD258), it creates a co-stimulatory signal that activates lymphoid cells and amplifies the immune response. This means HVEM/LIGHT binding combines immune system amplification with a pro-apoptotic effect, providing a two-pronged attack against cancer, and therefore making it a particularly promising target for cancer drug discovery.

HVEM also can bind to a protein called BTLA (CD272, IgSF), which negatively regulates T-cell immune responses. Thus, HVEM acts as a molecular switch, either activating or inhibiting the immune response, depending on which ligand it binds.