Killer-cell Immunoglobulin-like Receptors
High quality recombinant KIRs for your research
Killler-cell immunoglobulin-like receptors (KIRs) are a family of highly polymorphic receptors expressed on the surface of natural killer (NK) cells and a subset of T cells. By interacting with major histocompatibility (MHC) class I molecules, which are expressed on all cell types, they work to regulate the killing function of NK cells.
AMSBIO supplies a range of high quality KIR recombinant proteins, ideal for use as antigens and in protein binding studies.
Goodridge et al (2019) shows that educated NK cells expressing self-MHC specific inhibitory KIR accumulate granzyme B and Chondroitin Sulfate-4 in dense-core secretory lysosomes that converge close to the centrosome, as demonstrated by AMSBIO’s chondroitin sulfate stub antibodies.
Left: Representative immuno-EM section showing staining with gold-particle coated anti-Chondroitin Sulfate-4 (CS-4) stub antibody of NK cells expressing non-self or self KIR. Center: Number of gold particles (CS-4) per cell. Right: Density of gold particles (CS-4) per lysosomal area (μm2). From Goodridge et al (2019), reproduced under Creative Commons Attribution 4.0 International License)