Ab Heparan Sulfate, purified (clone F58-10E4), 50ug pack

Product Code
370255-S
$350.00
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RECOGNITION: The antibody (F58-10E4 clone) reacts with the 10E4 epitope, which is present in many types of heparan sulfate. 10E4 epitope includes (an) N-sulfated glucosamine residue(s) that are critical for the reactivity of the F58-10E4 antibody. The reactivity of the antibody with most heparan sulfates is nearly completely abolished after treatment of the glycosaminoglycan with bacterial heparatinase I (Heparinase III) from Flavobacterium heparinum (EC 4.2.2.8). The 10E4 antibody does not react with hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate or DNA.
More Information
SKU 370255-S
Size 0.05 mg
Host species Mouse
isotype IgM
Species reactivity Broad
Storage 2 - 8 deg C
Shipping Temp Gel Packs
Research Areas Glycobiology
For more details visit our Heparan Sulfate Antibodies page >

GRASP depletion‐mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion (2022)

Product Code: 370255-1, 370255-S
Author List: Erpan Ahat1 · Yuefan Song2 · Ke Xia2 · Whitney Reid1 · Jie Li1 · Sarah Bui1 · Fuming Zhang2 · Robert J. Linhardt2 · Yanzhuang Wang1,3
Journal: Cellular and Molecular Life Sciences

Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation. bioRxiv. (2022)

Product Code: 370255-1, 370255-S
Author List: Patil, N. P., Gomez-Hernandez, A., Zhang, F., Cancel, L., Feng, X., Yan, L., ... & Baker, A. B.
Journal: bioRxiv.

Adherent and suspension baby hamster kidney cells have a different cytoskeleton and surface receptor repertoire (2021)

Product Code: 370255-S; 370255-1
Author List: Dill, V., Pfaff, F., Zimmer, A., Beer, M., & Eschbaumer, M.
Journal: bioRxiv

Heparan sulfate is essential for thymus growth. (2021)

Product Code: 370255-S; 370255-1
Author List: Hsu, H. P., Chen, Y. T., Chen, Y. Y., Lin, C. Y., Chen, P. Y., Liao, S. Y., ... & Dzhagalov, I. L
Journal: Journal of Biological Chemistry, 296, 100419.

Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus. (2021)

Product Code: 370255-S
Author List: Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus
Journal: Blood Advances

Low retinoic acid levels mediate regionalization of the Sertoli valve in the terminal segment of mouse seminiferous tubules (2021)

Product Code: 370255-S; 370255-1
Author List: Imura-Kishi, K., Uchida, A., Tsunekawa, N., Suzuki, H., Takase, H. M., Hirate, Y., ... & Kanai, Y.
Journal: Scientific reports

Secretoglobin 3A2 eliminates human cancer cells through pyroptosis (2021)

Product Code: 370255-S; 370255-1
Author List: Yokoyama, S., Nakayama, S., Xu, L., Pilon, A. L., & Kimura, S.
Journal: Cell death discovery,

Secretoglobin 3A2 eliminates human cancer cells through pyroptosis (2021)

Product Code: 370255-S; 370255-1
Author List: Shigetoshi, Y., Shun, N., Xu, L., Pilon, A. L., & Shioko, K.
Journal:  Cell Death Discovery

 Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7 (2021)

Product Code: 370255-S
Author List: Kim, M. G., Kim, C. L., Kim, Y. S., Jang, J. W., & Lee, G. M.
Journal: Scientific reports,

Binding of the human antioxidation protein α1-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro (2021)

Product Code: 370255-S; 370255-1
Author List: Bergwik, J., Kristiansson, A., Larsson, J., Ekström, S., Åkerström, B., & Allhorn, M.
Journal: Redox biology, 41

Heparan Sulfate Is a Cellular Receptor for Enteric Human Adenoviruses. (2021)

Product Code: 370255-S; 370255-1
Author List: Rajan, A., Palm, E., Trulsson, F., Mundigl, S., Becker, M., Persson, B. D., ... & Lenman, A.
Journal: Viruses

The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination. (2021)

Product Code: 370255-S; 370255-1
Author List: Offeddu, G. S., Hajal, C., Foley, C. R., Wan, Z., Ibrahim, L., Coughlin, M. F., & Kamm, R. D.
Journal: Communications biology

Glycosaminoglycans located on neutrophils and monocytes impact on CXCL8-and CCL2-induced cell migration (2021)

Product Code: 370255-S
Author List: Gerlza, T., Nagele, M., Mihalic, Z., Trojacher, C., & Kungl, A.
Journal: Cytokine

Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells. (2021)

Product Code: 370255-S; 370255-1
Author List: Psefteli, P. M., Kitscha, P., Vizcay, G., Fleck, R., Chapple, S. J., Mann, G. E., ... & Siow, R. C.
Journal: Redox biology

Heparan Sulfate Deficiency in Cartilage: Enhanced BMP-Sensitivity, Proteoglycan Production and an Anti-Apoptotic Expression Signature after Loading. (2021)

Product Code: 370255-S
Author List: Gerstner, M., Severmann, A. C., Chasan, S., Vortkamp, A., & Richter, W.
Journal: International journal of molecular sciences

EXTRACELLULAR ACIDOSIS ENHANCES ZIKA VIRUS INFECTION BOTH IN HUMAN CELLS AND EX VIVO TISSUE CULTURES FROM FEMALE REPRODUCTIVE TRACT. (2021)

Product Code: 370255-S
Author List: Varese, A., Dantas, E., Paletta, A., Fitzgerald, W., Di Diego García, F., Cabrerizo, G., ... & Ceballos, A. (2021).
Journal: Emerging Microbes & Infections,

Endothelial glycocalyx shields the interaction of SARS-CoV-2 spike protein with ACE2 receptors (2021)

Product Code: 370255-S
Author List: Targosz-Korecka, M., Kubisiak, A., Kloska, D., Kopacz, A., Grochot-Przeczek, A., & Szymonski, M.
Journal: Scientific Reports

VISTA is an activating receptor in human monocytes (2021)

Product Code: 370255-S
Author List: Rogers, B. M., Smith, L., Dezso, Z., Shi, X., DiGiammarino, E., Nguyen, D., ... & Starbeck-Miller, G. R.
Journal: Journal of Experimental Medicine, 218(8), e20201601

Proteoglycan synthesis in conserved oligomeric Golgi subunit deficient HEK293T cells is affected differently, depending on the lacking subunit. (2021)

Product Code: 370255-S
Author List: Adusmalli, R., Åsheim, H. C., Lupashin, V., Blackburn, J. B., & Prydz, K.

Genome-wide CRISPR-Cas9 screen reveals common factors in dsRNA and Sindbis virus-induced cell death (2020)

Product Code: 370255-S, 370255-1
Author List: Olivier Petitjean, Erika Girardi, Richard Patryk Ngondo, Vladimir Lupashin, Sébastien Pfeffer
Journal: bioRXiv

Reduced Sulfation Enhanced Oxytosis and Ferroptosis in Mouse Hippocampal HT22 Cells (2020)

Product Code: 370255-1, 370255-S
Author List: Haruna Nagase, Yasuhiro Katagiri, Kentaro Oh-hashi, Herbert M. Geller and Yoko Hirata
Journal: Biomolecules

The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients (2020)

Product Code: 370255-1, 370255-s
Author List: BenoitYou, FrédéricMercier, EricAssenat, CaroleLanglois-Jacques, OlivierGlehen, JulienSoulé, LéaPayen, VahanKepenekian, MarieDupuy, FannyBelouin, EricMorency, VéroniqueSaywell, MaudFlacelière, PhilippeElies, PierreLiaud, ThibaultMazard, DelphineMaucort-Boulch, WinstonTan, BérengèreVire, LaurentVilleneuve, MarcYchou, ManishKohli, DominiqueJoubert and AlexandrePrieurs
Journal: EBioMedicine

Heparan sulfate attachment receptor is a major selection factor for attenuated enterovirus 71 mutants during cell culture adaptation (2020)

Product Code: 370255-S, 370255-1
Author List: Kyousuke Kobayashi, Katsumi Mizuta, Satoshi Koike
Journal: Plos Pathogens

Chikungunya virus strains from each genetic clade bind sulfated glycosaminoglycans as attachment factors (2020)

Product Code: 370255-S; 370255-1
Author List: McAllister, N., Liu, Y., Silva, L. M., Lentscher, A. J., Chai, W., Wu, N., ... & Dermody, T. S.
Journal: Journal of virology

Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection. (2020)

Product Code: 370255-S; 370255-1
Author List: Petitjean, O., Girardi, E., Ngondo, R. P., Lupashin, V., & Pfeffer, S.
Journal: mSphere

Expression and Its Role in Il-4 Driven Multinucleated Giant Cell Formation (2020)

Product Code: 370255-S; 370255-1
Author List: Brooks, P. J.
Journal: Doctoral dissertation

 Reduced cellular binding affinity has profoundly different impacts on the spread of distinct poxviruses (2020)

Product Code: 370255-S
Author List: Flores, E. B., Bartee, M. Y., & Bartee, E.
Journal: PloS one

Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44 (2020)

Product Code: 370260-1, 370260-S, 370255-1, 370255-S
Author List: Jing-You Guo, Chu-Hsuan Chiu, Mei-Jung Wang, Fu-An Li & Jeou-Yuan Chen
Journal: Journal of Biomedical Science

Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut (2019)

Product Code: 370255-S, 370255-1
Author List: Ma, H., Zhao, H., Liu, F., Zhao, H., Kong, R., Shi, L., ... & Li, Z.
Journal:  Biology Open, 8(10), bio047126

Functional Role of Glycosaminoglycans in Decellularized Lung Extracellular Matrix (2019)

Product Code: 370255-1, 370255-S
Author List: Uhl, F. E., Zhang, F., Pouliot, R. A., Uriarte, J. J., Enes, S. R., Han, X., ... & Hallgren, O.
Journal: Acta Biomaterialia

Heparan sulfate maintains adult midgut homeostasis in Drosophila (2019)

Product Code: 370255-1, 370255-s, 370260-S
Author List: Min Wei, Lin Shi, Ruiyan Kong, Hang Zhao and Zhouhua Li
Journal: Cell Biology International

Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau (2019)

Product Code: 370255-1, 370255-S
Author List: Hudák, A., Kusz, E., Domonkos, I., Jósvay, K., Kodamullil, A. T., Szilák, L., ... & Letoha, T.
Journal: Scientific reports, 9(1), 1-19

Heparan sulfate in human cutaneous Meissner's and Pacinian corpuscles (2019)

Product Code: 370730-1, 370730-s, 370255-1, 370255-S
Author List: Jorge García‐Piqueras Olivia García‐Suárez Yolanda García‐Mesa Beatriz García‐Fernandez Luis M. Quirós Ramón Cobo Benjamin Martín‐Biedma Jorge Feito José A. Vega
Journal: The anatomical record. Advances in integrative anatomy and evolutionary biology.

Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro (2019)

Product Code: 370255-S
Author List: Ashworth, J. C., Thompson, J. L., James, J. R., Slater, C. E., Pijuan-Galitó, S., Lis-Slimak, K., ... & Tassieri, M.
Journal: Matrix Biology

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau (2019)

Product Code: 370255-S
Author List: Huynh, M. B., Ouidja, M. O., Chantepie, S., Carpentier, G., Maïza, A., Zhang, G., ... & Papy-Garcia, D.
Journal: PloS one, 14(1), e0209573

Dual roles of heparanase in human carotid plaque calcification (2019)

Product Code: 370255-S
Author List: Aldi, S., Eriksson, L., Kronqvist, M., Lengquist, M., Löfling, M., Folkersen, L., ... & Österholm, C.
Journal: Atherosclerosis

Contribution of syndecans to cellular internalization and fibrillation of amyloid-β (1–42) (2019)

Product Code: 370255-S
Author List: Letoha, T., Hudák, A., Kusz, E., Pettkó-Szandtner, A., Domonkos, I., Jósvay, K., ... & Szilák, L.
Journal: Scientific Reports, 9(1), 1393

Glycoprotein K8.1A of Kaposi's sarcoma-associated herpesvirus is a critical B cell tropism determinant, independent of its heparan sulfate binding activity (2018)

Product Code: 370255-S
Author List: Dollery, S. J., Santiago-Crespo, R. J., Chatterjee, D., & Berger, E. A.
Journal: Journal of Virology, JVI-01876

Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell‐derived endothelium. (2018)

Product Code: 370255-S
Author List: Leuning, D. G., Witjas, F. M., Maanaoui, M., de Graaf, A. M., Lievers, E., Geuens, T., ... & de Boer, H.
Journal: American Journal of Transplantation.

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation (2018)

Product Code: 370255-S
Author List: Harding, I. C., Mitra, R., Mensah, S. A., Herman, I. M., & Ebong, E. E.
Journal: Journal of translational medicine, 16(1), 364

Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma (2017)

Product Code: 370255-S
Author List: Wiegner, R., Braun, C. K., Denk, S., Mayer, B., Cinelli, P., Radermacher, P., ... & Huber-Lang, M.
Journal: Journal of Critical Care

The glycocalyx regulates the uptake of nanoparticles by human endothelial cells in vitro. (2017)

Product Code: 370255-1, 370255-S
Author List: Möckl, L., Hirn, S., Torrano, A. A., Uhl, B., Bräuchle, C., & Krombach, F.
Journal: Nanomedicine, (0).

Control of cell shape, neurite outgrowth, and migration by a Nogo-A/HSPG Interaction (2017)

Product Code: 370255-S
Author List: Kempf, A., Boda, E., Kwok, J. C., Fritz, R., Grande, V., Kaelin, A. M., ... & Fawcett, J. W.
Journal: Developmental cell, 43(1), 24-34

Systemic monocyte chemotactic protein-1 inhibition modifies renal macrophages and restores glomerular endothelial glycocalyx and barrier function in diabetic nephropathy (2017)

Product Code: 370255-S
Author List: Boels, M. G., Koudijs, A., Avramut, M. C., Sol, W. M., Wang, G., van Oeveren-Rietdijk, A. M., ... & Eulberg, D.
Journal: The American Journal of Pathology

The CYCLOCALYX study: Ovulatory cycle affects circulating compartments of the endothelial glycocalyx in blood. (2017)

Product Code: 370255-S
Author List: Hulde, N., Rogenhofer, N., Brettner, F., Eckert, N. C., Götzfried, I., Nguyen, T., ... & Dendorfer, A.
Journal: American Journal of Reproductive Immunology.

Modulation of glycosaminoglycans affects PrPSc metabolism but does not block PrPSc uptake. (2015)

Product Code: 370255-1, 370255-S
Author List: Wolf, H., Graßmann, A., Bester, R., Hossinger, A., Möhl, C., Paulsen, L., ... & Vorberg, I.
Journal: Journal of virology, 89(19), 9853-9864.

Modulation of glycosaminoglycans affects PrPSc metabolism but does not block PrPSc uptake. (2015)

Product Code: 370255-1, 370255-S
Author List: Wolf, H., Graßmann, A., Bester, R., Hossinger, A., Möhl, C., Paulsen, L., ... & Vorberg, I.
Journal: Journal of virology, 89(19), 9853-9864.

The CD8-Derived Chemokine XCL1/Lymphotactin Is a Conformation-Dependent, Broad-Spectrum Inhibitor of HIV-1. (2013)

Product Code: 370255-1, 370255-S
Author List: Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman BF, et al.
Journal: PLoS Pathog 9(12): e1003852. doi:10.1371/journal.ppat.1003852

Interaction between mouse adenovirus type 1 and cell surface heparan sulfate proteoglycans. (2012)

Product Code: 370255-1, 370255-S
Author List: Lenaerts, L., van Dam, W., Persoons, L., & Naesens, L.
Journal: PloS one, 7(2), e31454.

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