HVEM/NF-kappaB Reporter Jurkat Recombinant Cell Line
Product Code
AMS.79310
$0.00
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Recombinant clonal stable Jurkat T cell line expressing firefly luciferase gene under the control of 4 copies of NF-kappaB response elements with constitutive expression of human HVEM (Herpes Virus Entry Mediator/ Tumor Necrosis Factor Receptor Superfamily Member 14/ TNFRSF14/ CD270/ GenBank Accession No. NM_003820). Following activation by human HVEM ligand LIGHT/ NF-kappaB transcription factors bind to the DNA response elements to induce transcription of the luciferase reporter gene.Materials Required but Not Supplied: Assay Medium: Thaw Medium 2 ( Cat. #60184)LIGHT/ His-Tag (Human) ( Cat. #71266LIGHT-CHO Recombinant Cell Line ( Cat. # 79262)96-well tissue culture-treated white clear-bottom assay plateOne-Step luciferase assay system ( # 60690) or other luciferase reagents for measuring firefly luciferase activityLuminometer
SKU | AMS.79310 |
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Size | 2 vials |
Species | Human |
Cell Line | JURKAT |
Tissue Type | Lymphoid Tissue |
Application | • Screen for agonists or antagonists of LIGHT-HVEM signaling in a physiological relevant cellular context • Characterize T cell-mediated immune responses of HVEM and its interactions with LIGHT • Screen co-stimulatory immune checkpoint molecules |
Gene synonyms | HVEM, TNFRSF14, CD270, HVEA, TR2, LIGHTR |
Storage | Store in liquid nitrogen immediately upon receipt. |
Shipping Temp | -80C (dry ice) |
Supplier Name | BPS |
Research Areas | Immunology |