Cynomolgus / Rhesus macaque B7-1 / CD80 Protein, Fc Tag (MALS verified)
Product Code
AMS.CD0-C5252-1mg
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B7-1 and B7-2, together with their receptors CD28 and CTLAÂÂ4, constitute one of the dominant co-stimulatory pathways that regulate T and BÂÂcell responses. Although both CTLAÂÂ4 and CD28 can bind to the same ligands, CTLAÂÂ4 binds to B7ÂÂ1 and B7ÂÂ2 with a 20  100 fold higher affinity than CD28 and is involved in the downÂÂregulation of the immune response.B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-CB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
SKU | AMS.CD0-C5252-1mg |
---|---|
Size | 1 mg |
Species | Monkey, Cynomolgus, Rhesus |
Expression Host | HEK293 |
Gene symbol | B7-1 |
aa sequence | Val 35 - Asn 242 |
Tag | FC |
Label/Conjugate | Unconjugated |
Accession No | N/A |
Gene description | Cynomolgus / Rhesus macaque |
Gene synonyms | CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7 |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |