Adenosine A2A Receptor Functional HEK293 Cell Line
Product Code
AMS.79381
$0.00
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Adenosine A2a receptor (A2aR or ADORA2A) stably expressed in HEK-293 cells. A2aR is a member of the seven transmembrane G protein-coupled receptor (GPCR) family. The activity of A2aR is mediated by G?s protein which activates adenylyl cyclase/ resulting in the synthesis of intracellular cAMP. The level of cAMP correlates with the respective adenosine (agonist) level/ and the cell line can be used to measure the EC50 and IC50 values of A2aR agonists or antagonists in a quantitative manner. Binding of extracellular adenosine ligand or its stable analog NECA (5?-(N-Ethylcarboxamido) adenosine) to the A2aR expressed on the surface of this cell line induces cAMP expression.
SKU | AMS.79381 |
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Size | 2 vials |
Application | • Screen for agonists or antagonists of A2aR in cell-based cAMP assays. • Study PD-1 and CTLA-4 combination therapy. • Screen co-inhibitor immune checkpoint molecules for cancer immunotherapy. |
Gene synonyms | A2aR, ADORA2A |
Storage | Immediately upon receipt/ store in liquid nitrogen. |
Shipping Temp | -80C (dry ice) |
Supplier Name | BPS |
Research Areas | Immunology |