Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
Product Code
AMS.TIT-H5253-1mg
Order Support
-
Email: [email protected]
Order Support
- Email: [email protected]
Order Support
- Email: [email protected]
Order Support
-
T: +1 (800) 987 0985 (toll free)
-
Email: [email protected]
Order Support
-
Email: [email protected]
Shipping Information
-
Delivery charges will be calculated during checkout
Product Updates
-
Keep up to date with product offers, resources and news
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
| SKU | AMS.TIT-H5253-1mg |
|---|---|
| Size | 1 mg |
| Species | Human |
| Expression Host | HEK293 |
| Gene symbol | TIGIT |
| aa sequence | Met 22 - Pro 141 |
| Tag | FC |
| Label/Conjugate | Unconjugated |
| Accession No | AAI01290.1 |
| Gene id | Human TIGIT, Mouse IgG2a Fc Tag, low endotoxin (TIT-H5253) is expressed from human 293 cells (HEK293). It contains AA Met 22 - Pro 141 (Accession # Q495A1-1). |
| Gene description | Human |
| Gene synonyms | TIGIT,VSIG9,VSTM3 |
| Format | Powder |
| Storage | -20C |
| Shipping Temp | RT |
| Supplier Name | ACROBiosystems Inc. |
