Mouse IL-4 R alpha / CD124 Protein, Fc Tag (MALS verified)
Product Code
AMS.ILR-M5252-100ug
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IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4RC (CD124)subunit and the 70 kDa common cytokine Cc chain (CD132).Interleukin 4 Receptor (IL4R) also known as CD124, IL4RC and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-ÂÂbiased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with ILÂÂ13Ra1 to form the type II receptor which is responsive to both ILÂÂ4 and ILÂÂ13. Interleukin-4 receptor has been shown to interact with SHC1.
SKU | AMS.ILR-M5252-100ug |
---|---|
Size | 100 ug |
Species | Mouse |
Expression Host | HEK293 |
Gene symbol | IL-4 R alpha |
aa sequence | Ile 26 - Arg 233 |
Tag | FC |
Label/Conjugate | Unconjugated |
Accession No | NP_001008700 |
Gene description | Mouse |
Gene synonyms | IL4R,CD124,IL4RA |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |