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Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag

Product Code
AMS.CSR-C5252-1mg
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$2,200.00

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Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeC subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
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SKU AMS.CSR-C5252-1mg
Size 1 mg
Species Monkey, Cynomolgus
Expression Host HEK293
Gene symbol M-CSF R
aa sequence Ile 99 - Pro 596
Tag FC
Label/Conjugate Unconjugated
Accession No N/A
Gene description Cynomolgus
Gene synonyms CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Format Powder
Storage -20C
Shipping Temp RT
Supplier Name ACROBiosystems Inc.
Immobilized Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) at 2 ?g/mL (100 ?L/well) on streptavidin precoated (0.2 ?g/well) plate, can bind Cynomolgus M-CSF R, Fc Tag (Cat. No. CSR-C5252) with a linear range of 1-39 ng/mL (QC tested).
Cynomolgus M-CSF R, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human M-CSF, His Tag (Cat. No. MCF-H5247) at 5 ?g/mL (100 ?L/well) can bind Cynomolgus M-CSF R, Fc Tag (Cat. No. CSR-C5252) with a linear range of 1-39 ng/mL (Routinely tested).

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