Human CD31 / PECAM-1 Protein, Fc Tag
Product Code
AMS.CD1-H5258-200ug
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Cluster of Differentiation 31 (CD31) is also known as Platelet endothelial cell adhesion molecule (PECAM-1), is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils, certain tumors, and is the only known member of the CAM family on platelets. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. CD31 plays a key role in removing aged neutrophils from the body. CD31 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin CvC3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is up-regulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages.
SKU | AMS.CD1-H5258-200ug |
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Size | 200 ug |
Species | Human |
Expression Host | HEK293 |
Gene symbol | CD31 |
aa sequence | Gln 28 - Lys 601 |
Tag | FC |
Label/Conjugate | Unconjugated |
Accession No | AAH22512.1 |
Gene synonyms | PECAM1,CD31,FLJ34100,FLJ58394 |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |