Culturing cells on flat plastic-ware results in artificial 2D monolayers of cells. This can result in a loss of cell interactions and therefore some of the functioning of the cell is lost. Alvetex have produced 3D cell cultures that allow cells to behave more naturally. Please click on the link to learn more about 3D cell culture.

Click this link to view a case study on the molecular profiling of breast cancer from formalin-fixed, archival material.

A 3D cell culture is a model where cellls can grow and assemble in three dimensions. 3D cell cultures allow for a more accurate representation of how cells behave naturally. Please click on the link to learn more about 3D cell cultures.

Gold coated substrates are used in a number of different areas within the life science academia and industry markets. Gold coated substrates have good resistance to oxidation, an inert surface for use with biological experimentation, are good conductors of electricity, and can easily form thiol chemistry self-assembled monolayers. To find out more about gold coated substrates please click on the link.

MAPTRIX Technology is a powerful platform technology that combines muscle adhesive proteins with specific bioactive peptides genetically incorporated into the protein. The bioactive peptide mimics the extracellular matrix. To learn more about these products please click on the link.

Oris have developed a novel assay that can be used to investigate cell migration. Please click the link to learn more about this assay.

Magnetic beads are used for the isolation of proteins and other areas of proteomics. To learn about the different types of magnetic beads that are available, and their uses please click on the link provided.

Tube formation assay represents a simple, quantitative, reliable and powerful model for studying inhibitors and activators of angiogenesis. Please click on the link to learn more about these products.

Please click this link to view a study on the substrate dependent effects of c-met inhibitors on HGF induced cell migration, using an Oris cell migration assay.

Cell invasion assays are a flexible, simple, quantitative, rapid and reliable way of quantifying the invasive capacity of many cell types. Cell invasion assays are used to measure tumour cell invasion and can be used to study endothelial activation and angiogenesis. Please click the link to find out more.

Please click this link to view a study into the differential effects of protease inhibitors in 2D and 3D cell invasion assays, using an Oris cell migration assay.

Cellufine is the liquid chromatography media for the purification of proteins, enzymes and other bioactive substances. Please click the link to learn more about Cellufine products.

Please click this link to view a study into the substratum-dependent effects of ROCK and myosin inhibitors during 2D and 3D migration of breast epithelial cells, using an Oris celll migration assay.

The Comet assay is a single cell electrophoresis assay for evaluating DNA damage in cells. Its applications include testing chemicals for toxicity, studying cellular response to DNA damage and as a screening assay for inhibitors to DNA repair. Please click the link to learn more about CometAssay.

Please click on this link to view the types of Assays that are produced by Oris.

Directed in vivo Angiogenesis Assay is a quatitative assay to assess angiogenesis in vivo. Please click the link to learn more about these assays.

Please click on the link to view a study in which the Oris Cell Migration Assay-Tricoated Kit on the Polarstar Omega was used to analyse cell migration

The Comet Assay is a singel cell gel electophoresis assay for evaluating DNA damage in cells. There are two comet assay formats, the Alkaline Comet is performed under denaturing conditions and is used to study single strand breaks in DNA, Neutral Comet is used under non denaturing conditions and is used to study double strand breaks in DNA. If you would like to learn more about DNA damage please click on the link.

In response to many types of DNA damage PARP polymerizes polymers of ADP ribose onto itself and other proteins. These proteins serve as scaffolding to recruit other repair proteins to the site of damage to repair the damaged DNA. Click this link to see how a PARP pharmacodynamic assay was created and verified.

ec23 is a stable synthetic retinoid designed to mimic biological activity of all-trans-retinoic acid. Ec23 is versatile and has many applications in modulating cell growth. Please click on the link to learn more about ec23 synthetis retinoid.

An endothelial progenitor cell is a bone marrow derived cell with properties similar to those of an embryonic angioblast. Endothelial progenitor cells are able to differentiate into a variety of mature vascular endothelial cells. To learn more about these types of cell please click on the link.

SERVA BluePrep have created multiple kits for protein and protein/nucleic acid isolation and purification. To see how they compare to their competitors please click on the link provided.

The extra cellular matrix is the living environment of the cell and functions as a mechanical support for cells and tissues. The extra cellular matrix influences cell development, movement and diffrentiation, is a reservoir for extracellular signalling molecules and coordinates cell function. To learn more about extra cellular matrices please click on the link.

Please click this link to view our presentation on antibody validation.