UPF 1069

Name: UPF 1069
Brand: AMS.27665-1
SKU: AMS.27665-1
Availability: InStock

Product Code

AMS.27665-1

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Overview

UPF 1069|a derivative of isoquinolinone|is a potent and selective inhibitor of poly-(ADP-ribose) polymerase 2 (PARP-2) that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors|UPF 1069 also inhibits PARP-1 with a lesser potency . Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage|UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices.

Product Specifications

More Information
SKU	AMS.27665-1
Size	10 mg
Gene synonyms	5-phenacyloxy-2H-isoquinolin-1-one
Cas no	1048371-03-4
Storage	Store at or below-20C. Solid form is stable at least 12 months from date of receipt# when stored as directed. Do not store aqueous solutions for more than one day.
Shipping Temp	Room temp. (continental US) or gel packs
Supplier Name	BPS

For more details visit our PARP Assays page >

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Affordable & consistent controls from 50 tumor cell lines, ideal for IHC, in situ hybridization & NGS applications.

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ALiCE® is a radically different approach to cell-free expression and a kit unlike any others.

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ALiCE® is a radically different approach to cell-free expression and a kit unlike any others.

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Prepared from Arthrobacter luteus, Zymolyase has a highly effective lytic activity against yeast cell walls.

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UPF 1069

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