Spike Trimer (S1+S2) (B.1.351|Beta Variant|?242-244) (SARS-CoV-2) Recombinant

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AMS.101091
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Recombinant SARS-CoV-2 Spike protein in its homotrimeric form|containing S1+S2 subunits and encompassing amino acids 16-1213. This protein corresponds to SARS-CoV-2 Variant B.1.351|also known as variant Beta originally discovered in South Africa|and contains the nine known mutations listed below|in addition to deletion 242-244. It also contains mutations 682RRAR685>A|K986P and V987P. The construct has a C-terminal His-tag (6xHis). Note that the expected MW of the S1+S2 monomer is 137kDa but migrates at a higher MW in SDS-PAGE due to glycosylation. The recombinant protein was affinity purified.

*Deletion 242-244 is known as 241-243 in some databases and on the CDC website. This is the same deletion. As stated by Tegally et al.|Nature 2021: We also observe a deletion of three amino acids at positions 242 to 244|which was seen in samples extracted and generated in different laboratories across the NGS-SA. This region is difficult to align; the deletion could potentially also be located at positions 241 to 243|but the resulting sequence would be exactly the same.
More Information
SKU AMS.101091
Size 100 ug
Species SARS-CoV-2
Expression Host HEK293
Tag His
Tag position C-terminal
Accession No MN908947
Gene id MN908947
Gene synonyms coronavirus, covid, covid-19, covid19, Sars-cov-2 B1351, 20H/501Y.V2, sars cov 2 Spike Trimer, sarscov2, South African Variant, B1351 mutation, South Africa coronavirus, SARS-CoV-2 S. African, ÃŽ², beta, deletion 242-244, deletion 241-243
Storage At least 6 months at -80C.
Shipping Temp -80C (dry ice)
Supplier Name BPS
For more details visit our SARS-CoV-2 Spike Mutants page >