Spike (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)
Product Code
AMS.79981-2
$0.00
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The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication/ the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes/ endothelial cells/ and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection.The SARS-CoV-2 Spike Pseudotyped Lentivirus were produced with SARS-CoV-2 Spike (Genbank Accession #QHD43416.1) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions also contain the enhanced GFP gene driven by a CMV promoter/ therefore/ the spike-mediated cell entry can be conveniently determined via eGFP activity. The SARS-CoV-2 Spike pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 in a Biosafety Level 2 facility.
SKU | AMS.79981-2 |
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Size | 500 ul x 2 |
Species | SARS-CoV-2 |
Application | 1. Study the mechanism of viral transduction. 2. Screening for neutralizing antibodies for SARS-CoV-2 Spike and ACE2. |
Accession No | QHD43416.1 |
Gene id | QHD43416.1 |
Gene synonyms | covid, covid-19, covid19, coronavirus, spike SARS lentivirus, Spike SARS-CoV-2 GFP reporter, Spike reporter |
Storage | Lentiviruses are shipped with dry ice. For long term storage/ it is recommended to store the virus at -80C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle. |
Shipping Temp | -80C (dry ice) |
Supplier Name | BPS |