Spike (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)

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AMS.79981-2
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The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication/ the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes/ endothelial cells/ and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection.The SARS-CoV-2 Spike Pseudotyped Lentivirus were produced with SARS-CoV-2 Spike (Genbank Accession #QHD43416.1) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions also contain the enhanced GFP gene driven by a CMV promoter/ therefore/ the spike-mediated cell entry can be conveniently determined via eGFP activity. The SARS-CoV-2 Spike pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 in a Biosafety Level 2 facility.
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SKU AMS.79981-2
Size 500 ul x 2
Species SARS-CoV-2
Application 1. Study the mechanism of viral transduction.
2. Screening for neutralizing antibodies for SARS-CoV-2 Spike and ACE2.
Accession No QHD43416.1
Gene id QHD43416.1
Gene synonyms covid, covid-19, covid19, coronavirus, spike SARS lentivirus, Spike SARS-CoV-2 GFP reporter, Spike reporter
Storage Lentiviruses are shipped with dry ice. For long term storage/ it is recommended to store the virus at -80C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle.
Shipping Temp -80C (dry ice)
Supplier Name BPS
For more details visit our Lentiviruses for SARS-CoV-2 & COVID-19 Research page >