Spike (P.1/ Gamma Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)

Product Code
AMS.78159-2
$0.00
Order Support
Shipping Information
Product Updates
  • Keep up to date with product offers, resources and news

  • Sign up

The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication/ the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes/ endothelial cells/ and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein and ACE2 may offer protection against the viral infection.
In Brazil/ a variant called P.1 was first identified in the summer of 2020. This variant has many mutations that may lead to higher transmissibility and infectivity. The Spike (P.1) (SARS-CoV-2) Pseudotyped Lentiviruses were produced with SARS-CoV-2 Variant Spike (Genbank Accession #QHD43416.1 with P.1 mutations/ see below for details) as the envelope glycoproteins instead of the commonly used VSVG. These pseudovirions contain the enhanced green fluorescent protein (eGFP) gene driven by a CMV promoter/ therefore/ the spike-mediated cell entry can be determined via eGFP fluorescence. The Spike (P.1) (SARS-CoV-2) pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 (P.1) variant using a Biosafety Level 2 facility.
More Information
SKU AMS.78159-2
Size 500 ul x 2
Species SARS-CoV-2
Application 1. Study the mechanism of viral transduction of SARS-CoV-2 (P.1 variant).
2. Screening for neutralizing antibodies for SARS-CoV-2 Spike (P.1 variant) and ACE2.
Gene synonyms coronavirus, covid, covid-19, covid19, Sars-cov-2 Brazil variant, sars cov 2, sarscov2, Brazil variant, Brazil lenti, Brazil mutation, Brazil lentivirus, pseudovirus, pseudovirion, eGFP reporter, 78159-1, 78159-2
Storage Lentiviruses are shipped with dry ice. For long term storage/ it is recommended to store the virus at -80C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle.
Shipping Temp -80C (dry ice)
Supplier Name BPS
For more details visit our SARS-CoV-2 Spike Mutants page >For more details visit our Lentiviruses for SARS-CoV-2 & COVID-19 Research page >