Spike (K417T/ E484K/ N501Y) (SARS-CoV-2) Pseudotyped Lentivirus (Luc Reporter)

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AMS.78143-2
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The Spike (K417T/ E484K/ N501Y) (SARS-CoV-2) Pseudotyped Lentiviruses were produced with SARS-CoV-2 Variant Spike (Genbank Accession #QHD43416.1 with mutations K417T/ E484K/ and N501Y) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions contain the firefly luciferase gene driven by a CMV promoter/ therefore/ the spike-mediated cell entry can be measured via luciferase activity. The Spike (SARS-CoV-2/ K417T/ E484K/ N501Y) pseudotyped lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 K417T/ E484K/ N501Y variant in intact cells using a Biosafety Level 2 facility.
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SKU AMS.78143-2
Size 500 ul x 2
Species SARS-CoV-2
Application 1. Study the mechanism of viral transduction of SARS-CoV-2 K417T/ E484K/ N501Y variant.
2. Screening for neutralizing antibodies that inhibit the binding of SARS-CoV-2 Spike (K417T/ E484K/ N501Y variant) to ACE2.
Gene synonyms coronavirus, covid, covid-19, covid19, Sars-cov-2 B.1.1.28.1 (P.1), sars cov 2, sarscov2, Brazil variant, Brazilian lenti, P1 lentivirus, pseudovirus, pseudovirion, 78143-1, 78143-2
Storage Lentiviruses are shipped with dry ice. For long term storage/ it is recommended to store the virus at -80C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle.
Shipping Temp -80C (dry ice)
Supplier Name BPS
For more details visit our SARS-CoV-2 Spike Mutants page >For more details visit our Lentiviruses for SARS-CoV-2 & COVID-19 Research page >