Spike (B.1.351/ Beta Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)

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AMS.78160-2
$0.00
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The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication/ the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes/ endothelial cells/ and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein and ACE2 may offer protection against the viral infection.
A variant called B.1.351 was first identified in the fall of 2020 in the Republic of South Africa. This South African variant/ also known as 501Y.V2/ has many mutations that may lead to higher transmissibility and infectivity. The Spike (B.1.351 Variant) (SARS-CoV-2) Pseudotyped Lentivirus were produced with SARS-CoV-2 B.1.351 Variant Spike (Genbank Accession #QHD43416.1 with B.1.351 mutations; see below for details) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions contain the enhanced green fluorescent protein (eGFP) gene driven by a CMV promoter/ therefore/ the spike-mediated cell entry can be determined via eGFP fluorescence. The Spike (B.1.351 Variant) (SARS-CoV-2) Pseudotyped Lentivirus can be used to measure the activity of neutralizing antibody against SARS-CoV-2 (B.1.351) variant in a Biosafety Level 2 facility.
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SKU AMS.78160-2
Size 500 ul x 2
Species SARS-CoV-2
Application 1. Study the mechanism of viral transduction of SARS-CoV-2 (B.1.351 variant)
2. Screening for neutralizing antibodies for SARS-CoV-2 Spike (B.1.351 variant) and ACE2.
Gene synonyms coronavirus, covid, covid-19, covid19, 501Y.V2, sars cov 2, sarscov2, South Africa variant, South Africa lenti, South Africa mutation, South Africa lentivirus, pseudovirus, pseudovirion, eGFP reporter, B1135, 78160-1, 78160-2
Storage Lentiviruses are shipped with dry ice. For long term storage/ it is recommended to store the virus at -80C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle.
Shipping Temp -80C (dry ice)
Supplier Name BPS
For more details visit our SARS-CoV-2 Spike Mutants page >For more details visit our Lentiviruses for SARS-CoV-2 & COVID-19 Research page >