Shc(Phospho Tyr349) Polyclonal Antibody

Product Code
AMS.BT-AP14203-100ul
$230.00
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This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
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SKU AMS.BT-AP14203-100ul
Size 100 ul
Host species Rabbit
isotype IgG
Application WB, IF, IHC-P, ELISA
Species reactivity Human, Mouse, Rat
Gene synonyms SHC-transforming protein 1; SHC1; SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1
Storage -20C for 1 year