SACS Polyclonal Antibody

Product Code
AMS.BT-AP14028-100ul
$230.00
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This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins (Parfitt et al., PubMed: 19208651).
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SKU AMS.BT-AP14028-100ul
Size 100 ul
Host species Rabbit
isotype IgG
Application IF, IHC-P
Species reactivity Human, Mouse
Gene synonyms Sacsin ;DnaJ homolog subfamily C member 29;DNAJC29
Storage -20C for 1 year