Romidepsin (FK228|depsipeptide)

Name: Romidepsin (FK228|depsipeptide)
Brand: AMS.27646-2
SKU: AMS.27646-2
Availability: InStock

Product Code

AMS.27646-2

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Overview

Romidepsin|also known as FK228 or depsipeptide|is a potent and selective inhibitor of HDAC1 and HDAC2|which are associated with the regulation of re-expression of silenced tumor suppressor genes. It was the first HDAC inhibitor to manifest anti-tumor activity and originally isolated from a rod-shaped Gram-negative bacterium|Chromobacterium violaceum|found in a Japanese soil sample. Romidepsin exhibits a stronger inhibition towards HDAC1 and HDAC2 enzymes (class I)|removing acetyl groups from the lysine residues of N-terminal histone tails and maintaining a more open and transcriptionally active chromatin state|than HDAC4 and HDAC6 enzymes (class II). Besides HDAC inhibition|romidepsin is also able to induce cell cycle arrest|cellular differentiation|apoptosis and alteration of gene expression in adult malignancies.

Product Specifications

More Information
SKU	AMS.27646-2
Size	5 mg
Gene synonyms	Istodax; FK228; FR 901228, FK-228; Romidepsin; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Storage	Store at or below-20C. Solid form is stable at least 12 months from date of receipt# when stored as directed. Do not store aqueous solutions for more than one day.
Shipping Temp	Room temp. (continental US) or gel packs
Supplier Name	BPS

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Romidepsin (FK228|depsipeptide)

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