PROTAC® Optimization Kit for BET Bromodomain-Cereblon Binding

Name: PROTAC® Optimization Kit for BET Bromodomain-Cereblon Binding
Brand: AMS.79770
SKU: AMS.79770
Availability: InStock

Product Code

AMS.79770

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Overview

The PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding is designed for testing and profiling of PROTACs directed against BET Bromodomain family and Cereblon complex. Cereblon (CRBN) is a Substrate recognition component of a DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding comes in a convenient AlphaLISA® format, with dBET1 PROTAC, Immuno Buffer 1, and purified BRD3(BD2) and CRBN for 384 reactions. (+)JQ1 is included as a control inhibitor of PROTAC binding to BRD3(BD2). With this kit, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and BRD3(BD2), one of BET bromodomains. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts._x000D_

Product Specifications

More Information
SKU	AMS.79770
Size	384 rxns.
Gene synonyms	CRBN, Protein X 0001, MRT2A MRT2
Storage	At least six months from date of receipt when stored as directed.
Shipping Temp	-80°C (dry ice)
Supplier Name	BPS Bioscience Inc

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PROTAC® Optimization Kit for BET Bromodomain-Cereblon Binding

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