Kinases
Huge collection of tyrosine kinases, lipid kinases & serine/threonine kinases
Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate.
Receptor Tyrosine Kinases
Receptor tyrosine kinases are the high affinity cell surface receptors for growth factors, cytokines and hormones. Receptor tyrosine kinases are key regulators of normal cellular processes and also play critical roles in the development and progression of many types of cancer.
| Name | Packsize | Order |
|---|---|---|
| ABL (T315I) Assay Kit | 96 reactions | View |
| ALK1 Kinase Assay Kit | 96 reactions | View |
| ALK2 Kinase Assay Kit | 96 reactions | View |
| AXL Kinase Assay Kit | 96 reactions | View |
| BTK Assay Kit | 96 reactions | View |
| CDK1 Assay Kit | 96 reactions | View |
| CDK2 Assay Kit | 96 reactions | View |
| CDK4 Assay Kit | 96 reactions | View |
| CDK5 Assay Kit | 96 reactions | View |
| CDK7 Assay Kit | 96 reactions | View |
| CDK9 Assay Kit | 96 reactions | View |
| CSF1R / SRE - Reporter HEK293 Recombinant Cell Line | 2 vials | View |
| FGFR2 Assay Kit | 96 reactions | View |
| FGFR3 (L496V) Assay Kit | 96 reactions | View |
| FGFR3 (V443L) Assay Kit | 96 reactions | View |
| FGFR3 (V443M) Assay Kit | 96 reactions | View |
| FLT3 Kinase Assay Kit | 96 reactions | View |
| GSK3alpha Assay Kit | 96 reactions | View |
| GSK3beta Assay Kit | 96 reactions | View |
| HPK1 Assay Kit | 96 reactions | View |
| JAK1 (Janus Kinase 1) Assay Kit | 96 reactions | View |
| JAK2 (Janus Kinase 2) Assay Kit | 96 reactions | View |
| JAK3 (Janus Kinase 3) Assay Kit | 96 reactions | View |
| LCK Assay Kit | 96 reactions | View |
| PDGFRalpha (D842I) Assay Kit | 96 reactions | View |
| PDGFRalpha (D842V) Assay Kit | 96 reactions | View |
| PDGFRalpha (D842Y) Assay Kit | 96 reactions | View |
| PI3Kalpha (p110alpha/p85) Assay Kit | 96 reactions | View |
| PI3Kbeta (p110beta/p85alpha) Assay Kit | 96 reactions | View |
| PI3Kdelta (p110delta/p85alpha) Assay Kit | 96 reactions | View |
| PI3Kgamma (p110gamma/PIK3R5) Assay Kit | 96 reactions | View |
| RET Assay Kit | 96 reactions | View |
| RIPK1 Kinase Assay Kit (384-well) | 384 reactions | View |
| RIPK1 Kinase Assay Kit | 96 reactions | View |
| RIPK2 Kinase Assay Kit | 96 reactions | View |
| SRC Assay Kit | 96 reactions | View |
| SYK Assay Kit | 96 reactions | View |
| TYK2 (Tyrosine Kinase 2) Assay Kit | 96 reactions | View |
| TYR Phosphorylation Assay Kit | 96 reactions | View |
| TYRO3 Kinase Assay Kit | 96 reactions | View |
| TrkA Assay Kit | 96 reactions | View |
| VEGFR3(FLT4) Kinase Assay Kit | 96 reactions | View |
| YES1 Assay Kit | 96 reactions | View |
| c-Mer Kinase Assay Kit | 96 reactions | View |
| c-Met Kinase Assay Kit | 96 reactions | View |
| c-Raf Kinase Assay Kit | 96 reactions | View |
| cKIT Assay Kit | 96 reactions | View |
Cytoplasmic Tyrosine Kinases
Three major classes of non-receptor (cytoplasmic) tyrosine kinases have been identified: Src, Abl and Jak. Many of the non-receptor tyrosine kinases are involved in the mediation of immune and inflammatory responses, and misregulation of these enzymes has been linked to multiple human cancers.
| Name | Packsize | Order |
|---|---|---|
| ACK1, GST-tag | 10 ug | View |
| BMX, GST-tag | 10 ug | View |
| BRK, GST-tag | 10 ug | View |
| BTK, GST-tag | 10 ug | View |
| CSK, GST-tag | 10 ug | View |
| FAK, GST-tag | 10 ug | View |
| FES, His-FLAG-tag | 10 ug | View |
| FYN, FLAG-tag | 10 ug | View |
| Jak1, GST-tag | 10 ug | View |
| Jak2 (JH1 domain), His-tag | 20 ug | View |
| Jak2 (JH1, JH2 domain), His-GST-tags | 20 ug | View |
| Jak3, His-tag | 20 ug | View |
| LCK, GST-tag | 10 ug | View |
| Mouse ITK, GST-tag | 10 ug | View |
| PYK2, His-tag | 10 ug | View |
| Rat ITK, GST-tag | 10 ug | View |
| SRC, GST-tag | 10 ug | View |
| SRC, His-tag | 10 ug | View |
| SYK, Catalytic, GST-tag | 10 ug | View |
| SYK, Full length, GST-tag | 10 ug | View |
| Tyk2, His-tag | 10 ug | View |
| Yes1, GST-tag | 10 ug | View |
| ZAP70, GST-tag | 10 ug | View |
Lipid Kinases
Lipid kinases are one of the most promising new classes of potential drug targets. PI-3 and sphingosine kinases regulate a wide variety of cellular functions, including cell growth, proliferation, differentiation, intracellular trafficking, motility, and survival. As a result, defects in lipid kinase function lead to multiple disease states, including several forms of cancer and diabetes.
| Name | Packsize | Order |
|---|---|---|
| ALK , GST-tag | 10 ug | View |
| AXL, FLAG-Tag | 10 ug | View |
| Abl Kinase Mutant (T315I), His-tag | 10 ug | View |
| Abl Kinase, His-tag | 10 ug | View |
| Axl, GST-tag | 10 ug | View |
| CSF1R, GST-tag | 10 ug | View |
| CSF1R, untagged (FMS, CD115) | 10 ug | View |
| DDR1, GST-tag | 10 ug | View |
| EGFR (L858R), GST-tag | 10 ug | View |
| EGFR (T790M), GST-tag | 10 ug | View |
| EGFR (T790M, C797S, L858R), GST-tag | 10 ug | View |
| EGFR (T790M, L858R), GST-tag | 10 ug | View |
| EGFR, GST-tag | 10 ug | View |
| EPHA2, His-tag | 10 ug | View |
| EPHA4, GST-tag | 10 ug | View |
| EPHB2, His-tag | 10 ug | View |
| EPHB4, His-tag | 10 ug | View |
| FGFR2, GST-tag | 10 ug | View |
| FGFR3 (L496V), His-Tag | 10 ug | View |
| FGFR3 (V443L), His-Tag | 10 ug | View |
| FGFR3 (V443M), His-Tag | 10 ug | View |
| FGFR4, GST-tag | 10 ug | View |
| Flt1, His-tag | 10 ug | View |
| Flt3, His-tag | 10 ug | View |
| HER2, GST-tag | 10 ug | View |
| HER4, GST-tag | 10 ug | View |
| Insulin receptor (INSR), GST-tag | 10 ug | View |
| JAK2-His-Avi-Tag, Biotin-Labeled | 10 ug | View |
| Jak2 (JH1, JH2 domain), GST-Tag, Avi-Tag, Biotin | 10 ug | View |
| Jak2 (JH2 Domain) (E596A, V617F, W659A, W777A, F794H), His-Tag | 20 ug | View |
| Jak2 (JH2 Domain) (V617F, W659A, W777A, F794H), His-Tag | 20 ug | View |
| Jak2 (JH2 Domain) (W659A, W777A,F794H), His-Tag | 20 ug | View |
| Jak2 (V617F), FLAG-Avi-Tag, Biotin-Labeled | 10 ug | View |
| Jak2 (V617F), GST-Tag, Avi-Tag, Biotin-Labeled | 10 ug | View |
| Jak2 (V617F), His-Avi-Tag, Biotin-Labeled | 10 ug | View |
| Jak2 (W659A, W777A, F794H), His-Avi-Tag, Biotin | 10 ug | View |
| Jak2, FLAG-Avi-Tag, Biotin-Labeled | 10 ug | View |
| MUSK, His-tag | 10 ug | View |
| Mouse EGFR, FLAG-tag | 10 ug | View |
| PDGFRalpha (D842V), GST-Tag | 10 ug | View |
| PDGFRalpha (D842Y), GST-Tag | 10 ug | View |
| PDGFRbeta, His-tag | 10 ug | View |
| ROR1, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled | 50 ug | View |
| ROR2, Fc-Fusion (IgG1), Avi-Tag HiP™ | 100 ug | View |
| ROR2, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled HiP™ | 50 ug | View |
| ROS1, GST-tag | 10 ug | View |
| Ret, GST-tag | 10 ug | View |
| TNK1, GST-Th-Tag | 100 ug | View |
| TRKA, GST-tag | 10 ug | View |
| TRKB, GST-tag | 10 ug | View |
| TRKC, GST-tag | 10 ug | View |
| TYRO3, GST-tag | 10 ug | View |
| Tie2, GST-tag | 10 ug | View |
| Tie2, His-tag | 10 ug | View |
| VEGFR2 (KDR), GST-tag | 10 ug | View |
| VEGFR2 / NFAT Reporter - HEK293 Recombinant Cell Line | 2 vials | View |
| VEGFR3 (Flt4), GST-tag | 10 ug | View |
| c-Mer, GST-tag | 10 ug | View |
| cKit (D816V), His-tag | 10 ug | View |
| cKit (V560G), His-tag | 10 ug | View |
| cKit (V654A), His-tag | 10 ug | View |
| cKit, His-tag | 10 ug | View |
| cMet, GST-tag | 10 ug | View |
Serine/Threonine Kinases
Serine/threonine protein kinases phosphorylate the OH group of specific serine or threonine residues. Over 125 different human serine/threonine kinases have been identified. The proteins are involved in the regulation of nearly every cell signaling pathway, including gene expression, growth, proliferation, differentiation, adhesion, motility, and death.
| Name | Packsize | Order |
|---|---|---|
| CERK, FLAG-Tag (Mouse) | 10 ug | View |
| CERK, FLAG-Tag (Rat) | 10 ug | View |
| Ceramide Kinase, FLAG-tag | 10 ug | View |
| IP6K2, Biotin-labeled, His-tag, Avi-tag | 10 ug | View |
| IP6K2, FLAG-His-tags | 20 ug | View |
| Mouse Sphingosine kinase 1a, His-tag | 10 ug | View |
| Mouse Sphingosine kinase 2, His-tag | 10 ug | View |
| PI3 kinase (p110alpha/p85alpha), FLAG-tag | 20 ug | View |
| PI3 kinase (p110alpha/p85alpha), GST-tag | 20 ug | View |
| PI3 kinase (p110beta/p85alpha), FLAG-tag | 20 ug | View |
| PI3 kinase (p110delta/p85alpha), GST-tag | 20 ug | View |
| PI3 kinase (p110gamma/PIK3R5) complex, His-tag, GST-tag | 20 ug | View |
| PI3 kinase (p120gamma), His-tag | 20 ug | View |
| PI3 kinase [p110alpha(E545K)/p85alpha], FLAG-tag | 20 ug | View |
| PI3 kinase [p110alpha(H1047R)/p85alpha], FLAG-tag | 20 ug | View |
| PI3 kinase p110alpha(K111N)/p85alpha Recombinant | 20 ug | View |
| Sphingosine kinase 1, His-tag | 20 ug | View |
| Sphingosine kinase 2 (long), His-tag | 10 ug | View |
| Sphingosine kinase 2, His-tag | 20 ug | View |
| VPS34, FLAG-tag | 20 ug | View |
| p85alpha, His-tag | 100 ug | View |
