
Kinases
Huge collection of tyrosine kinases, lipid kinases & serine/threonine kinases
Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate.
Receptor Tyrosine Kinases
Receptor tyrosine kinases are the high affinity cell surface receptors for growth factors, cytokines and hormones. Receptor tyrosine kinases are key regulators of normal cellular processes and also play critical roles in the development and progression of many types of cancer.
Name | Packsize | Order |
---|---|---|
ABL (T315I) Assay Kit | 96 rxns. | View |
ALK1 (ACVRL1 Kinase Assay Kit | 96 rxns. | View |
ALK2 (ACVR1) Kinase Assay Kit | 96 rxns. | View |
AXL Kinase Assay Kit | 96 rxns. | View |
BTK Assay Kit | 96 rxns. | View |
CDK1 Assay Kit | 96 rxns. | View |
CDK2 Assay Kit | 96 rxns. | View |
CDK4 Assay Kit | 96 rxns. | View |
CDK5 Assay Kit | 96 rxns. | View |
CDK7 Assay Kit | 96 rxns. | View |
CSF1R / SRE - Reporter HEK293 Recombinant Cell Line | 2 vials | View |
FGFR2 Assay Kit | 96 rxns. | View |
FLT3 Kinase Assay Kit | 96 rxns. | View |
GSK3α Assay Kit | 96 rxns. | View |
GSK3β Kinase Assay Kit | 96 rxns. | View |
HPK1 Assay Kit | 96 rxns. | View |
JAK1 (Janus Kinase 1) Assay Kit | 96 rxns. | View |
JAK2 (Janus Kinase 2) Assay Kit | 96 rxns. | View |
JAK3 (Janus Kinase 3) Assay Kit | 96 rxns. | View |
LCK Assay Kit | 96 rxns. | View |
PDGFRα (D842V) Assay Kit | 96 rxns. | View |
PI3Kα (p110α/p85) Assay Kit | 96 rxns. | View |
PI3Kβ (p110β/p85α) Assay Kit | 96 rxns. | View |
PI3Kγ (p110γ/PIK3R5) Assay Kit | 96 rxns. | View |
PI3Kδ (p110δ/p85α) Assay Kit | 96 rxns. | View |
RET Assay Kit | 96 rxns. | View |
RIPK1 Kinase Assay Kit (384-well) | 384 rxns. | View |
RIPK1 Kinase Assay Kit | 96 rxns. | View |
RIPK2 Kinase Assay Kit | 96 rxns. | View |
SRC Assay Kit | 96 rxns. | View |
SYK Assay Kit | 96 rxns. | View |
TYK2 (Tyrosine Kinase 2) Assay Kit | 96 rxns. | View |
TYR Phosphorylation Assay Kit | 96 rxns. | View |
TYRO3 Kinase Assay Kit | 96 rxns. | View |
TrkA Assay Kit | 96 rxns. | View |
VEGFR3(FLT4) Kinase Assay Kit | 96 rxns. | View |
c-Mer Kinase Assay Kit | 96 rxns. | View |
c-Met Kinase Assay Kit | 96 rxns. | View |
c-Raf Kinase Assay Kit | 96 rxns. | View |
cKIT Assay Kit | 96 rxns. | View |
Cytoplasmic Tyrosine Kinases
Three major classes of non-receptor (cytoplasmic) tyrosine kinases have been identified: Src, Abl and Jak. Many of the non-receptor tyrosine kinases are involved in the mediation of immune and inflammatory responses, and misregulation of these enzymes has been linked to multiple human cancers.
Name | Packsize | Order |
---|---|---|
ACK1, GST-tag Recombinant | 10 µg | View |
BMX, GST-tag Recombinant | 10 µg | View |
BRK, GST-tag Recombinant | 10 µg | View |
BTK, GST-His-Tag Recombinant | 10 µg | View |
CSK, GST-His-Th-Tag Recombinant | 10 µg | View |
FAK, GST-Tag Recombinant | 10 µg | View |
FES, His-FLAG-tag Recombinant | 10 µg | View |
FYN, FLAG-Tag Recombinant | 10 µg | View |
JAK1, GST-tag Recombinant | 10 µg | View |
JAK2 (JH1 domain), His-Tag Recombinant | 20 µg | View |
JAK2 (JH1, JH2 domain), His-GST-Tags Recombinant | 20 µg | View |
JAK3, His-tag Recombinant | 20 µg | View |
LCK, GST-tag Recombinant | 10 µg | View |
Mouse ITK, GST-tag Recombinant | 10 µg | View |
PYK2, His-tag Recombinant | 10 µg | View |
Rat ITK, GST-tag Recombinant | 10 µg | View |
SRC, GST-tag Recombinant | 10 µg | View |
SRC, His-Tag Recombinant | 10 µg | View |
SYK, Catalytic, GST-Tag Recombinant | 10 µg | View |
SYK, Full length, GST-tag Recombinant | 10 µg | View |
Tyk2, His-Tag Recombinant | 10 µg | View |
Yes1, GST-tag Recombinant | 10 µg | View |
ZAP70, GST-tag Recombinant | 10 µg | View |
Lipid Kinases
Lipid kinases are one of the most promising new classes of potential drug targets. PI-3 and sphingosine kinases regulate a wide variety of cellular functions, including cell growth, proliferation, differentiation, intracellular trafficking, motility, and survival. As a result, defects in lipid kinase function lead to multiple disease states, including several forms of cancer and diabetes.
Name | Packsize | Order |
---|---|---|
ALK , GST-tag Recombinant | 10 µg | View |
AXL, FLAG-Tag Recombinant | 10 µg | View |
Abl Kinase Mutant (T315I), His-tag Recombinant | 10 µg | View |
Abl Kinase, His-tag Recombinant | 10 µg | View |
Axl, GST-Tag Recombinant | 10 µg | View |
CSF1R, GST-His-Tag Recombinant | 10 µg | View |
CSF1R, untagged (FMS, CD115) Recombinant | 10 µg | View |
DDR1, GST-tag Recombinant | 10 µg | View |
EGFR (L858R), GST-Tag, His-Tag Recombinant | 10 µg | View |
EGFR (T790M), GST-tag, His-tag, Recombinant | 10 µg | View |
EGFR (T790M, C797S, L858R), GST-tag, His-Tag Recombinant | 10 µg | View |
EGFR (T790M, L858R), GST-tag, His-tag Recombinant | 10 µg | View |
EGFR, GST-tag, His-tag, Recombinant | 10 µg | View |
EPHA2, His-tag Recombinant | 10 µg | View |
EPHA4, GST-tag Recombinant | 10 µg | View |
EPHB2, His-tag Recombinant | 10 µg | View |
EPHB4, His-tag Recombinant | 10 µg | View |
FGFR2, GST-tag Recombinant | 10 µg | View |
FGFR3 (L496V), His-Tag Recombinant | 10 µg | View |
FGFR3 (V443L), His-Tag Recombinant | 10 µg | View |
FGFR3 (V443M), His-Tag Recombinant | 10 µg | View |
FGFR4, GST-tag Recombinant | 10 µg | View |
FLT1, His-tag Recombinant | 10 µg | View |
Flt3, His-tag Recombinant | 10 µg | View |
HER2, GST-Tag Recombinant | 10 µg | View |
HER4, GST-tag Recombinant | 10 µg | View |
Insulin receptor (INSR), GST-tag Recombinant | 10 µg | View |
JAK2 (JH1, JH2 domain), GST-Tag, Avi-Tag, Biotin (Dephosphorylated) Recombinant | 10 µg | View |
JAK2 (JH2 Domain) (E596A, V617F, W659A, W777A, F794H), His-Tag Recombinant | 20 µg | View |
JAK2 (JH2 Domain) (V617F, W659A, W777A, F794H), His-Tag Recombinant | 20 µg | View |
JAK2 (JH2 Domain) (W659A, W777A,F794H), His-Tag Recombinant | 20 µg | View |
JAK2 (JH2 Domain), His-Avi-Tag, Biotin-Labeled Recombinant | 10 µg | View |
JAK2 (V617F) (JH1, JH2 Domain), GST-Tag, Avi-Tag, Biotin-Labeled (Dephosphorylated) Recombinant | 10 µg | View |
JAK2 (V617F) (JH2 Domain), His-Avi-Tag, Biotin-Labeled Recombinant | 10 µg | View |
JAK2 (V617F), FLAG-Avi-Tag, Biotin-Labeled (Dephosphorylated) Recombinant | 10 µg | View |
JAK2 (W659A, W777A, F794H) (JH2 Domain), His-Avi-Tag, Biotin-Labeled Recombinant | 10 µg | View |
JAK2, FLAG-Avi-Tag, Biotin-Labeled (Dephosphorylated) Recombinant | 10 µg | View |
MUSK, His-tag Recombinant | 10 µg | View |
Mouse EGFR, FLAG-Tag Recombinant | 10 µg | View |
PDGFRα (D842V), GST-Tag Recombinant | 10 µg | View |
PDGFRα (D842Y), GST-Tag Recombinant | 10 µg | View |
PDGFRβ, His-tag Recombinant | 10 µg | View |
ROR1, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled Recombinant | 50 µg | View |
ROR2, Fc-Fusion (IgG1), Avi-Tag HiP™ Recombinant | 100 µg | View |
ROR2, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled HiP™ Recombinant | 50 µg | View |
ROS1, GST-His-tag Recombinant | 10 µg | View |
Ret, GST-tag Recombinant | 10 µg | View |
TNK1, GST-Th-Tag Recombinant | 100 µg | View |
TRKA, GST-tag Recombinant | 10 µg | View |
TRKB, GST-tag Recombinant | 10 µg | View |
TRKC, GST-tag Recombinant | 10 µg | View |
TYRO3, GST-tag Recombinant | 10 µg | View |
Tie2, GST-tag Recombinant | 10 µg | View |
Tie2, His-tag Recombinant | 10 µg | View |
VEGFR2 (KDR), GST-Tag Recombinant | 10 µg | View |
VEGFR2 / NFAT Reporter - HEK293 Recombinant Cell Line | 2 vials | View |
VEGFR3 (FLT4), GST-tag Recombinant | 10 µg | View |
c-Mer, GST-tag (Human) Recombinant | 10 µg | View |
c-Met, GST-tag Recombinant | 10 µg | View |
cKit (D816V), His-tag Recombinant | 10 µg | View |
cKit (V560G), His-tag Recombinant | 10 µg | View |
cKit (V654A), His-tag Recombinant | 10 µg | View |
cKit, His-tag Recombinant | 10 µg | View |
Serine/Threonine Kinases
Serine/threonine protein kinases phosphorylate the OH group of specific serine or threonine residues. Over 125 different human serine/threonine kinases have been identified. The proteins are involved in the regulation of nearly every cell signaling pathway, including gene expression, growth, proliferation, differentiation, adhesion, motility, and death.
Name | Packsize | Order |
---|---|---|
CERK, FLAG-Tag (Mouse) Recombinant | 10 µg | View |
CERK, FLAG-Tag (Rat) Recombinant | 10 µg | View |
Ceramide Kinase, FLAG-tag Recombinant | 10 µg | View |
IP6K2, Biotin-labeled, His-tag, Avi-tag Recombinant | 10 µg | View |
IP6K2, FLAG-His-tags Recombinant | 20 µg | View |
Mouse Sphingosine kinase 1a, His-tag Recombinant | 10 µg | View |
Mouse Sphingosine kinase 2, His-tag Recombinant | 10 µg | View |
PI3 kinase (p110α/p85α) Recombinant | 20 µg | View |
PI3 kinase (p110β/p85α), FLAG-tag Recombinant | 20 µg | View |
PI3 kinase (p110γ/PIK3R5) complex, His-tag, GST-tag Recombinant | 20 µg | View |
PI3 kinase (p110δ/p85α) Recombinant | 20 µg | View |
PI3 kinase (p120γ), His-tag Recombinant | 20 µg | View |
PI3 kinase p110α(E545K)/p85α Recombinant | 20 µg | View |
PI3 kinase p110α(H1047R)/p85α, FLAG-Tag Recombinant | 20 µg | View |
PI3 kinase p110α(K111N)/p85α Recombinant | 20 µg | View |
Sphingosine Kinase 2 (Transcript Variant 1), His-Tag Recombinant | 10 µg | View |
Sphingosine kinase 1, His-tag Recombinant | 20 µg | View |
Sphingosine kinase 2, His-tag Recombinant | 20 µg | View |
VPS34, FLAG-tag Recombinant | 20 µg | View |
p85α, His-tag Recombinant | 100 µg | View |