Kinases

Huge collection of tyrosine kinases, lipid kinases & serine/threonine kinases

Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate.

Cytoplasmic Tyrosine Kinases

Three major classes of non-receptor (cytoplasmic) tyrosine kinases have been identified: Src, Abl and Jak. Many of the non-receptor tyrosine kinases are involved in the mediation of immune and inflammatory responses, and misregulation of these enzymes has been linked to multiple human cancers.

NamePacksize Order
ACK1, GST-tag Recombinant10 µg View
BMX, GST-tag Recombinant10 µg View
BRK, GST-tag Recombinant10 µg View
BTK, GST-His-Tag Recombinant10 µg View
CSK, GST-His-Th-Tag Recombinant10 µg View
FAK, GST-Tag Recombinant10 µg View
FES, His-FLAG-tag Recombinant10 µg View
FYN, FLAG-Tag Recombinant10 µg View
JAK1, GST-tag Recombinant10 µg View
JAK2 (JH1 domain), His-Tag Recombinant20 µg View
JAK2 (JH1, JH2 domain), His-GST-Tags Recombinant20 µg View
JAK3, His-tag Recombinant20 µg View
LCK, GST-tag Recombinant10 µg View
Mouse ITK, GST-tag Recombinant10 µg View
PYK2, His-tag Recombinant10 µg View
Rat ITK, GST-tag Recombinant10 µg View
SRC, GST-tag Recombinant10 µg View
SRC, His-Tag Recombinant10 µg View
SYK, Catalytic, GST-Tag Recombinant10 µg View
SYK, Full length, GST-tag Recombinant10 µg View
Tyk2, His-Tag Recombinant10 µg View
Yes1, GST-tag Recombinant10 µg View
ZAP70, GST-tag Recombinant10 µg View

Lipid Kinases

Lipid kinases are one of the most promising new classes of potential drug targets. PI-3 and sphingosine kinases regulate a wide variety of cellular functions, including cell growth, proliferation, differentiation, intracellular trafficking, motility, and survival. As a result, defects in lipid kinase function lead to multiple disease states, including several forms of cancer and diabetes.

NamePacksize Order
ALK , GST-tag Recombinant10 µg View
AXL, FLAG-Tag Recombinant10 µg View
Abl Kinase Mutant (T315I), His-tag Recombinant10 µg View
Abl Kinase, His-tag Recombinant10 µg View
Axl, GST-Tag Recombinant10 µg View
CSF1R, GST-His-Tag Recombinant10 µg View
CSF1R, untagged (FMS, CD115) Recombinant10 µg View
DDR1, GST-tag Recombinant10 µg View
EGFR (L858R), GST-Tag, His-Tag Recombinant10 µg View
EGFR (T790M), GST-tag, His-tag, Recombinant10 µg View
EGFR (T790M, C797S, L858R), GST-tag, His-Tag Recombinant10 µg View
EGFR (T790M, L858R), GST-tag, His-tag Recombinant10 µg View
EGFR, GST-tag, His-tag, Recombinant10 µg View
EPHA2, His-tag Recombinant10 µg View
EPHA4, GST-tag Recombinant10 µg View
EPHB2, His-tag Recombinant10 µg View
EPHB4, His-tag Recombinant10 µg View
FGFR2, GST-tag Recombinant10 µg View
FGFR3 (L496V), His-Tag Recombinant10 µg View
FGFR3 (V443L), His-Tag Recombinant10 µg View
FGFR3 (V443M), His-Tag Recombinant10 µg View
FGFR4, GST-tag Recombinant10 µg View
FLT1, His-tag Recombinant10 µg View
Flt3, His-tag Recombinant10 µg View
HER2, GST-Tag Recombinant10 µg View
HER4, GST-tag Recombinant10 µg View
Insulin receptor (INSR), GST-tag Recombinant10 µg View
JAK2 (JH1, JH2 domain), GST-Tag, Avi-Tag, Biotin (Dephosphorylated) Recombinant10 µg View
JAK2 (JH2 Domain) (E596A, V617F, W659A, W777A, F794H), His-Tag Recombinant20 µg View
JAK2 (JH2 Domain) (V617F, W659A, W777A, F794H), His-Tag Recombinant20 µg View
JAK2 (JH2 Domain) (W659A, W777A,F794H), His-Tag Recombinant20 µg View
JAK2 (JH2 Domain), His-Avi-Tag, Biotin-Labeled Recombinant10 µg View
JAK2 (V617F) (JH1, JH2 Domain), GST-Tag, Avi-Tag, Biotin-Labeled (Dephosphorylated) Recombinant10 µg View
JAK2 (V617F) (JH2 Domain), His-Avi-Tag, Biotin-Labeled Recombinant10 µg View
JAK2 (V617F), FLAG-Avi-Tag, Biotin-Labeled (Dephosphorylated) Recombinant10 µg View
JAK2 (W659A, W777A, F794H) (JH2 Domain), His-Avi-Tag, Biotin-Labeled Recombinant10 µg View
JAK2, FLAG-Avi-Tag, Biotin-Labeled (Dephosphorylated) Recombinant10 µg View
MUSK, His-tag Recombinant10 µg View
Mouse EGFR, FLAG-Tag Recombinant10 µg View
PDGFRα (D842V), GST-Tag Recombinant10 µg View
PDGFRα (D842Y), GST-Tag Recombinant10 µg View
PDGFRβ, His-tag Recombinant10 µg View
ROR1, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled Recombinant50 µg View
ROR2, Fc-Fusion (IgG1), Avi-Tag HiP™ Recombinant100 µg View
ROR2, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled HiP™ Recombinant50 µg View
ROS1, GST-His-tag Recombinant10 µg View
Ret, GST-tag Recombinant10 µg View
TNK1, GST-Th-Tag Recombinant100 µg View
TRKA, GST-tag Recombinant10 µg View
TRKB, GST-tag Recombinant10 µg View
TRKC, GST-tag Recombinant10 µg View
TYRO3, GST-tag Recombinant10 µg View
Tie2, GST-tag Recombinant10 µg View
Tie2, His-tag Recombinant10 µg View
VEGFR2 (KDR), GST-Tag Recombinant10 µg View
VEGFR2 / NFAT Reporter - HEK293 Recombinant Cell Line2 vials View
VEGFR3 (FLT4), GST-tag Recombinant10 µg View
c-Mer, GST-tag (Human) Recombinant10 µg View
c-Met, GST-tag Recombinant10 µg View
cKit (D816V), His-tag Recombinant10 µg View
cKit (V560G), His-tag Recombinant10 µg View
cKit (V654A), His-tag Recombinant10 µg View
cKit, His-tag Recombinant10 µg View

Serine/Threonine Kinases

Serine/threonine protein kinases phosphorylate the OH group of specific serine or threonine residues. Over 125 different human serine/threonine kinases have been identified. The proteins are involved in the regulation of nearly every cell signaling pathway, including gene expression, growth, proliferation, differentiation, adhesion, motility, and death.

NamePacksize Order
CERK, FLAG-Tag (Mouse) Recombinant10 µg View
CERK, FLAG-Tag (Rat) Recombinant10 µg View
Ceramide Kinase, FLAG-tag Recombinant10 µg View
IP6K2, Biotin-labeled, His-tag, Avi-tag Recombinant10 µg View
IP6K2, FLAG-His-tags Recombinant20 µg View
Mouse Sphingosine kinase 1a, His-tag Recombinant10 µg View
Mouse Sphingosine kinase 2, His-tag Recombinant10 µg View
PI3 kinase (p110α/p85α) Recombinant20 µg View
PI3 kinase (p110β/p85α), FLAG-tag Recombinant20 µg View
PI3 kinase (p110γ/PIK3R5) complex, His-tag, GST-tag Recombinant20 µg View
PI3 kinase (p110δ/p85α) Recombinant20 µg View
PI3 kinase (p120γ), His-tag Recombinant20 µg View
PI3 kinase p110α(E545K)/p85α Recombinant20 µg View
PI3 kinase p110α(H1047R)/p85α, FLAG-Tag Recombinant20 µg View
PI3 kinase p110α(K111N)/p85α Recombinant20 µg View
Sphingosine Kinase 2 (Transcript Variant 1), His-Tag Recombinant10 µg View
Sphingosine kinase 1, His-tag Recombinant20 µg View
Sphingosine kinase 2, His-tag Recombinant20 µg View
VPS34, FLAG-tag Recombinant20 µg View
p85α, His-tag Recombinant100 µg View

Kinases