PDE10A-HEK293 Recombinant Cell line

Name: PDE10A-HEK293 Recombinant Cell line
Brand: AMS.60410
SKU: AMS.60410
Availability: InStock

Product Code

AMS.60410

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Overview

Recombinant HEK293 cell line expressing human PDE10A2 (phosphodiesterase 10A/ accession number NM_006661). N-terminal His-tagged human PDE10A2 has been stably expressed in a human embryonic kidney (HEK293) cell line. PDE10A2 expression was confirmed by Western blotting. The function of PDE10A2 was confirmed by cAMP detection assay. Forskolin is commonly used to raise levels of intracellular cyclic AMP (cAMP). When HEK293 cells are activated by forskolin/ cAMP levels are upregulated in parental cells/ whereas cells overexpressing PDE10A show reduction in cAMP accumulation. Inhibition of PDE10A activity restores cAMP levels.

Product Specifications

More Information
SKU	AMS.60410
Size	2 vials
Species	Human
Cell Line	HEK293
Tissue Type	Kidney
Application	Useful to monitor cAMP and PDE10A signaling pathway activity and to screen activators or inhibitors of PDE10A.
Accession No	NM_006661
Gene id	NM_006661
Gene synonyms	PDE10A, phosphodiesterase 10A
Storage	Store in liquid nitrogen immediately upon receipt.
Shipping Temp	-80C (dry ice)
Supplier Name	BPS

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PDE10A-HEK293 Recombinant Cell line

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