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Human Noggin, also known as symphalangism 1 (SYM1) or synostoses (multiple) syndrome 1 (SYNS1), GenBank Accession No. NM_005450, a.a. 28-232(end), disulfide-linked homodimer. MW=~28kDa (monomer). Source: human 293 cells. Endotoxin Level: <1 EU/ug. Biological Activity: measured by Noggin's ability to inhibit BMP-4-induced alkaline phosphatase production by C2C12 mouse myoblast cells. The ED50 is < 20 ng/ml in the presence of 30 ng/ml of human BMP-4. Formulation: Lyophilized from a 0.2 uM filtered, aqueous solution. Reconstitution: Supplied as a lyophilized solid. Reconstitute in sterile water with 0.1% BSA to a final concentration of 0.1 mg/ml. Final formulation will be 50 mM Tris, pH 8.0, 1.2 M NaCl, 2.7 mM KCl, 0.1% BSA.
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SKU 90256-2
Size 50 ug
Alternate SKU AMS.90256-2
Species Human
Expression Host Freestyle 293-F Cells
aa sequence 28-232(end)
Application Useful for cell culture and for the study of signaling and developmental pathways. Also useful for receptor binding studies, screening inhibitors, and selectivity profiling.
Accession No NM_005450
Gene synonyms Noggin, symphalangism 1, SYM1, synostoses (multiple) syndrome 1, SYNS1
Format Lyophilized solid
Storage >=12 months (lyophilized) at -20C. Store reconstituted protein in aliquots at -20C to -70C for up to 6 months. Avoid freeze/thaw cycles.
Shipping Temp -80C
Supplier Name BPS
Research Areas Immunology