Dr. Mairi Sandison (Biomedical Engineering) and Dr. Michele Zagnoni (Electronic & Electrical Engineering) at the University of Strathclyde have developed a novel single-cell culture approach for tracking phenotypic heterogeneity in vascular smooth muscle cells (vSMCs), changes that underlie cardiovascular diseases. They and doctoral student Ellis Smith (funded by Medical Research Scotland) developed a microwell array for the long-term confinement of the progeny of single vSMCs, exploiting Lipidure®-CM as a highly effective cell repellent coating. They also exploited CELLBANKER® cryopreservation media to preserve freshly isolated vSMCs, increasing the number of experiments that can be performed from a single tissue.
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Effective confinement of vSMCs by Lipidure®-CM
Examples of vSMC tracking in microwell arrays achieved following cryopreservation in CELLBANKER® 2
- Smith, E., Zagnoni, M. & Sandison, M.E. Cellular microarrays for assessing single-cell phenotypic changes in vascular cell populations. Biomed Microdevices 25, 11 (2023). https://doi.org/10.1007/s10544-023-00651-5
- For further information on Cellbanker® cryopreservation media, please visit https://www.amsbio.com/cellbanker-cell-freezing-media/ or contact AMSBIO on+44-1235-828200 / +1-617-945-5033 / [email protected].
- For further information on Lipidure®, please visit https://www.amsbio.com/lipidure-coat-plates/ or contact AMSBIO on+44-1235-828200 / +1-617-945-5033 / [email protected].