Neural Stem Cells, Neurons & Astrocytes
AMSBIO offers a range of neural stem cells (NSCs) and neural lineage progenitors (astrocytes, cortical neurons and dopaminergic neurons), derived from control human iPSCs using non-integrating episomal-based differentiation methods. We also provide optimized media and kits for easy differentiation to high quality neural lineage cells.
Features
- Different NSC lines, each derived from a single control iPSC line or engineered iPSC line: male (cord blood), female (cord blood), male (fibroblasts) and more
- Physiologically relevant cell line models
- A consistent and reliable source of differentiated mature, functional neurons and glial cells
Master iPSCs for Neural Differentiation
Applications
These control iPSC cell lines from multiple donors are feeder and integration free, making them ideal for use in multiple different applications including:
- CRISPR/Cas9 genome editing
- Differentiation to isogenic somatic cell lineages (neural stem cells/astrocytes/neurons)
- Drug toxicity and efficacy screening
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Astrocyte Precursor and Mature Cells
Our Astrocyte Precursor and Mature Cells are derived from neural stem cells differentiated from fully characterized, normal karyotype human induced pluripotent stem cells (hiPSCs). Proprietary induction protocols are utilized with xeno-free and integration-free derivation and culture to produce high purity astrocytes. The astrocyte precursor cells can be further differentiated into mature astrocytes using the Astrocyte Differentiation Media (ASE-9322MDM) and maintained using our Astrocyte Maintenance Media (ASE-9322MCM).
Benefits
- High purity neurons: >90% Tuj1+ neurons and < 5% GFAP+ cells
- High cell viability of neurons post-thaw (>80%)
- Isogenic lineages of mixed neurons and associated neuronal derivatives available from two different control iPSC lines (male ASE-9109 and female ASE-9110)
- Functionally viable neurons capable of neuronal excitability and synapse formation
- Long-term viability in cell culture and consistency in results (>30 days): affords greater flexibility in designing high throughput drug screening and testing
Applications
- Electrophysiology and synaptic functionality assays
- Neurotoxicity and neuroprotection screening tests
- Physiologically relevant disease modelling platform
- Gene profiling under isogenic conditions to understand gene functionality associated with neurological diseases
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Dopaminergic Neurons and Neuronal Cell Lines
Benefits
- High purity (>90%) cells expressing neural stem cell markers: SOX1, PAX6 and Nestin
- Fully characterized by immunocytochemistry and whole genome profiling
- Provides a consistent and reliable source of differentiated mature, functional neurons and glial cells
Applications
- Neurotoxicity screening
- Neuroprotection assays and research
- Drug screening
- Reliable predictable models of neurological disorders
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Neural Stem Cell Induction, Maintenance, and Maturation Media
Our range of serum-free neural cell media is designed specifically for iPSC-derived neural stem cells, neurons, astrocytes and dopaminergic neurons.
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