Lentiviruses for SARS-CoV-2 Research

Your safe alternative for studying coronavirus species

Given the safety measures required in handling live SARS-CoV-2, a safer alternative is recombinant lentiviruses pseudotyped with the SARS-CoV-2 Spike (S) protein. This is ideal for COVID-19 research; such as virus infectivity study, drug screening (neutralising assays) and vaccine development under less stringent biosafety conditions (BSL-2). AMSBIO provides a service to produce recombinant lentivirus that can be pseudotyped with either wildtype or mutant S proteins from any type of coronavirus species.

Our Services

Pseudotyped SARS-CoV-2 Lentivirus Construction

          • The SARS-CoV-2 pseudotyped Lentivirus' are produced by replacing the commonly used vesicular stomatitis virus G (VSV-G) envelope glycoprotein with Spike protein.
          • Pseudotyping available with wild type or mutant spike proteins from a wide range of coronavirus species.
          • Unlimited customization options including addition of reporter genes (e.g. eGFP, luciferase) for monitoring viral entry.
          • Both in vitro and in vivo grade scales available.

Why use AMSBIO's lentiviral services?

          • Safe-to-use (self-inactivating) lentiviral particles can deliver your gene into a wide range of cell lines including non-dividing, primary or stem cells
          • Engineered in-house lentiviral vectors allow for highly efficient gene integration into the cell genome
          • You can choose to have an inducible or constitutive expression
          • High titer lentivirus that is monitored by a fluorescent protein (not fused with your target)
          • Our experts have years of experience in lentiviral cloning and expression
          • Fast turnaround time
          • The best price and the best quality in its class

Safety Precaution

Please note that although our lentiviral vectors contain all necessary bio-safety features, work with lentiviral particles should be carried out under Biological Safety Level 2 (BL2) or higher. Please conduct a thorough risk assessment for your project and contact your health and safety facilities for local guidelines and regulations.

Lentivirus & Adenovirus & AAV Request Form

Let's get started

Complete our service request form and we will contact you to discuss your requirements.