Lamin A/C Polyclonal Antibody

Product Code
AMS.BT-AP04933-50ul
$150.00
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The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in LMNA lead to several diseases: emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
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SKU AMS.BT-AP04933-50ul
Size 50 ul
Host species Rabbit
isotype IgG
Application WB, IHC-P, ELISA
Species reactivity Human, Mouse, Rat
Gene id 4000
Gene synonyms LMNA; LMN1; Prelamin-A/C
Storage -20C for one year
Shipping Temp Gel Packs