In Vitro Angiogenesis Assays
Simple, semi-quantitative tools for assessing angiogenesis
Angiogenesis is a multi-step process involving the sprouting and growth of new blood vessels from existing vasculature. In multiple in vivo models, stem cells have been shown to modulate angiogenesis in response to injury, disease and cancer. The initial stages of angiogenesis involve recruitment (invasion & migration) of endothelial cells followed by tubule formation and maturation.
In vitro angiogenesis assays provide a controlled environment to focus on individual stages of the angiogenic process. In vitro assays are designed to study endothelial cell invasion and tubule formation. Stem cells and/or compounds modulating angiogenesis are easily introduced into the assay resulting in a quantitative assessment of pro- or inhibitory angiogenic bioactivity.
Extracellular Matrix Tube Formation Assay
Measures the ability of endothelial cells to form three-dimensional tube-like structures on an extracellular matrix substrate, providing a quick assessment of angiogenesis in an in vitro environment.
- 96 well plate format
- Takes less than 18 hours to determine angiogenesis in vitro
- Includes a tested inhibitor as a negative control
- Easy to use
- Allows for easy introduction of stem cells and/or compounds modulating angiogenesis
- Quickly determines angiogenesis in vitro
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MAPTrix™ Angio Kits
MAPTrix™ Angio Kits provide a defined 3D microenvironment to regulate integrin-mediated signaling events for endothelial tube formation in a reliable and reproducible manner. Based on our MAPtrix Hygel technology where defined ECM attachment motifs are expressed on recombinant Mussel Adhesive protein with PEG linker to enable formation of 3D hydrogel
Kit can be customized to design a surface that induces specific angiogenic integrin mediated signaling environment for specialty applications. Basic MAPTrix™ Angio Kits are summarized as below:
|MAPTrix™ HyGel Protein Derivative||Mimetic Motif|
|Angio F (Laminin + Fibronectin)||IKVAV + GRGDSP|
|Angio C (Laminin + Collagen)||IKVAV + GFPGER|
AMSBIO is a global source for MAPtrix products. MAPtrix is a trademark of Kollodis BioSciences, Inc.