Human R-Spondin 1 / RSPO1 Protein, His Tag

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R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/beta-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for beta-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus.
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SKU AMS.RS1-H4221-50ug
Size 50 ug
Species Human
Expression Host HEK293
Gene symbol R-Spondin 1
aa sequence Ser 21 - Ala 263
Tag His
Label/Conjugate Unconjugated
Accession No NP_001033722.1
Gene synonyms RSPO1,CRISTIN3,FLJ40906,RP11-566C13.1,R-spondin-1
Format Powder
Storage -20C
Shipping Temp RT
Supplier Name ACROBiosystems Inc.
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