Histone Methylation
Discover our collection of histone methylation research tools
Methyltransferases are enzymes that transfer a methyl group from S-adenosylmethionine (SAM) to their substrates. Methyltransferases can methylate lysines and arginines on histone side chains. Lysines may be mono-, di-, or trimethylated and arginines may be mono-, symmetrically or asymmetrically dimethylated. Each of these different ‘flavors’ of methylation can result in different chromatin conformations and gene expression levels.
Our Products
| Name | Packsize | Order |
|---|---|---|
| DNMT1 Chemiluminescent Assay Kit | 96 reactions | View |
| DOT1L (KMT4) Chemiluminescent Assay Kit | 96 reactions | View |
| EHMT1 (GLP) Chemiluminescent Assay Kit | 96 reactions | View |
| EZH1 Chemiluminescent Assay Kit | 384 reactions | View |
| EZH1 Chemiluminescent Assay Kit | 96 reactions | View |
| EZH2 (A677G) Chemiluminescent Assay Kit | 384 reactions | View |
| EZH2 (A677G) Chemiluminescent Assay Kit | 96 reactions | View |
| EZH2 (A738T) Chemiluminescent Assay Kit | 384 reactions | View |
| EZH2 (A738T) Chemiluminescent Assay Kit | 96 reactions | View |
| EZH2 (Y641F) Chemiluminescent Assay Kit | 384 reactions | View |
| EZH2 (Y641F) Chemiluminescent Assay Kit | 96 reactions | View |
| EZH2 (Y641N) Chemiluminescent Assay Kit | 384 reactions | View |
| EZH2 (Y641N) Chemiluminescent Assay Kit | 96 reactions | View |
| EZH2 (Y641N) TR-FRET Assay Kit | 384 reactions | View |
| EZH2 Chemiluminescent Assay Kit | 384 reactions | View |
| EZH2 Chemiluminescent Assay Kit | 96 reactions | View |
| EZH2 Homogeneous Assay Kit | 384 reactions | View |
| EZH2(Y641F) TR-FRET Assay Kit | 384 reactions | View |
| EZH2-EED Binding Assay Kit | 384 reactions | View |
| G9a Chemiluminescent Assay Kit | 96 reactions | View |
| G9a Homogeneous Assay Kit | 384 reactions | View |
| Histone H3(K9) Universal Methyltransferase Assay Kit | 96 rxns. | View |
| Histone H4(R3) Methyltransferase Assay Kit | 96 reactions | View |
| METTL3/METTL14 Complex Chemiluminescent Assay Kit | 96 reactions | View |
| MLL1 Complex Chemiluminescent Assay Kit | 96 reactions | View |
| MLL3 Complex Chemiluminescent Assay Kit | 96 reactions | View |
| MLL4 Complex Chemiluminescent Assay Kit | 96 reactions | View |
| NSD1 Chemiluminescent Assay Kit | 96 reactions | View |
| NSD2 Chemiluminescent Assay Kit | 384 reactions | View |
| NSD2 Chemiluminescent Assay Kit | 96 reactions | View |
| PRDM9 Chemiluminescent Assay Kit | 96 reactions | View |
| PRMT1 Chemiluminescent Assay Kit | 96 reactions | View |
| PRMT1 Homogeneous Assay Kit | 384 reactions | View |
| PRMT3 Chemiluminescent Assay Kit | 96 reactions | View |
| PRMT3 Homogeneous Assay Kit | 384 reactions | View |
| PRMT4 Chemiluminescent Assay Kit | 96 reactions | View |
| PRMT4 Homogeneous Assay Kit | 384 reactions | View |
| PRMT5 Chemiluminescent Assay Kit | 384 reactions | View |
| PRMT5 Chemiluminescent Assay Kit | 96 reactions | View |
| PRMT5 Homogeneous Assay Kit | 384 reactions | View |
| PRMT5 TR-FRET Assay Kit | 384 reactions | View |
| PRMT6 (HRMT1L6) Chemiluminescent Assay Kit | 96 reactions | View |
| PRMT6 (HRMT1L6) Homogeneous Assay Kit | 384 reactions | View |
| PRMT7 Homogeneous Assay Kit (Automethylation) | 384 reactions | View |
| PRMT7 Homogeneous Assay Kit (Histone H2b) | 384 reactions | View |
| PRMT8 Chemiluminescent Assay Kit | 96 reactions | View |
| PRMT8 Homogeneous Assay Kit | 384 reactions | View |
| PRMT9 Homogeneous Assay Kit | 384 reactions | View |
| SETD2 Chemiluminescent Assay Kit | 96 reactions | View |
| SMYD2 (KMT3C) Chemiluminescent Assay Kit | 96 reactions | View |
| SMYD3 Homogeneous Assay Kit | 384 reactions | View |
| SMYD4 Chemiluminescent Assay Kit | 96 reactions | View |
| SUV39H1 Chemiluminescent Assay Kit | 96 reactions | View |
| SUV39H2 Activity Assay Kit | 96 reactions | View |
| SUV4-20H1 Chemiluminescent Assay Kit | 96 reactions | View |
| Name | Packsize | Order |
|---|---|---|
| AEBP2, His-tag | 50 ug | View |
| DOT1L (KMT4), GST-tag | 50 ug | View |
| EED, FLAG-tag | 50 ug | View |
| EHMT1 (GLP), GST-tag | 50 ug | View |
| EZH1/EED/SUZ12, His-tag | 50 ug | View |
| EZH1/EED/SUZ12/RbAp48/AEBP2, His-tag | 50 ug | View |
| EZH2 (A677G)/EED/SUZ12/RbAp48/AEBP2, His-tag | 20 ug | View |
| EZH2 (A677T)/EED/SUZ12/RbAp48/AEBP2, His-tag | 20 ug | View |
| EZH2 (A687V)/EED/SUZ12/RbAp48/AEBP2, His-tag | 20 ug | View |
| EZH2 (A738T) /EED/SUZ12/RbAp48/AEBP2, FLAG-Tag, His-Tag | 20 ug | View |
| EZH2 (E740K)/EED/SUZH12/RbAp48/AEBP2, FLAG-tag, His-tag | 20 ug | View |
| EZH2 (F667I)/EED/SUZH12/RbAp48/AEBP2, FLAG-tag, His-tag | 20 ug | View |
| EZH2 (H689Y)/EED/SUZ12/RbAp48/AEBP2, FLAG-tag, His-tag | 20 ug | View |
| EZH2 (P132S)/EED/SUZ12/RbAp48/AEBP2, FLAG-tag, His-tag | 20 ug | View |
| EZH2 (R679C)/EED/SUZH12/RbAp48/AEBP2, FLAG-tag, His-tag | 20 ug | View |
| EZH2 (Y641C) /EED/SUZ12/RbAp48/AEBP2, His-tag | 20 ug | View |
| EZH2 (Y641F) /EED/SUZ12/RbAp48/AEBP2, His-tag | 20 ug | View |
| EZH2 (Y641H) /EED/SUZ12/RbAp48/AEBP2, His-tag | 20 ug | View |
| EZH2 (Y641N) /EED/SUZ12/RbAp48/AEBP2, His-tag, FLAG-tag | 20 ug | View |
| EZH2 (Y641S) /EED/SUZ12/RbAp48/AEBP2, His-tag | 20 ug | View |
| EZH2 (del153Y)/EED/SUZ12/RbAp48/AEBP2, FLAG, His-tag | 20 ug | View |
| EZH2 (non-complexed), His-GST-tags | 20 ug | View |
| EZH2 / EED / SUZ12, His-tag, FLAG-tag | 50 ug | View |
| EZH2/EED, His-tag, FLAG-tag | 20 ug | View |
| EZH2/EED/SUZ12/RbAp48, His-tag, FLAG-tag | 50 ug | View |
| EZH2/EED/SUZ12/RbAp48/AEBP2 Complex, FLAG-tag, His-tag | 50 ug | View |
| EZH2/SUZ12/RbAp48, His-GST-tags, His-tag | 20 ug | View |
| G9a (EHMT2), GST-tag (E. coli-derived) | 50 ug | View |
| G9a (EHMT2), GST-tag (Sf9-derived) | 20 ug | View |
| METTL3, FLAG-Tag | 10 ug | View |
| METTL3/METTL14 Protein Complex, FLAG-Tag, His-Tag | 10 ug | View |
| MLL1/WDR5/Ash2L/RbBP5 (MLL1/WAR Complex), His-tag | 50 ug | View |
| MLL1/WDR5/Ash2L/RbBP5/DPY30 (MLL1/WARD Complex), FLAG, His-tag | 50 ug | View |
| MLL3/WDR5/Ash2L/RbBP5/DPY30 Complex | 50 ug | View |
| Metnase (SETMAR), FLAG-tag | 20 ug | View |
| NNMT, His-Tag | 50 ug | View |
| NSD1, GST-tag | 50 ug | View |
| NSD2 (catalytic domain), GST-tag | 50 ug | View |
| NSD3 (1021-1322) (WHSC1L1), GST-tag | 50 ug | View |
| PRDM12, GST-tag | 50 ug | View |
| PRDM14, GST-tag | 50 ug | View |
| PRMT1, GST-tag (E. coli-derived) | 50 ug | View |
| PRMT1, GST-tag (Sf9-derived) | 20 ug | View |
| PRMT2, FLAG-Tag | 10 ug | View |
| PRMT3, GST-tag | 50 ug | View |
| PRMT4 (CARM1), FLAG-tag (HEK293-derived) | 20 ug | View |
| PRMT5, FLAG-Avi-Tag, Biotin-Labeled | 10 ug | View |
| PRMT5/MEP50, Biotin-Labeled | 10 ug | View |
| PRMT5/MEP50, FLAG-tag, His-tag (HEK293-derived) | 20 ug | View |
| PRMT5/MEP50, FLAG-tag, His-tag (Sf9-derived) | 20 ug | View |
| PRMT6 (HRMT1L6), His-tag | 20 ug | View |
| PRMT7, FLAG-tag | 20 ug | View |
| PRMT8, His-FLAG-tags | 20 ug | View |
| PRMT9|FLAG-Tag|His-Tag Recombinant | 20 ug | View |
| PRMT9|FLAG-Tag|Strep-Tag Recombinant | 20 ?g | View |
| SAP145|GST-Tag Recombinant | 20 ug | View |
| SETD2, GST-tag | 50 ug | View |
| SMYD2 (KMT3C), FLAG-tag | 20 ug | View |
| SMYD3 (35-end), GST-tag | 20 ug | View |
| SMYD3 (full length), FLAG-tag | 20 ug | View |
| SMYD4, FLAG-tag | 20 ug | View |
| SUV39H1, GST-tag | 50 ug | View |
| SUV39H2, GST-tag | 50 ug | View |
| SUV4-20H1, GST-tag | 50 ug | View |
| SUV4-20H2, GST-tag | 50 ug | View |
| SUZ12, His-FLAG-tags | 20 ug | View |
| Set7/9 (Sf9), His-GST-tags | 50 ug | View |
| Set7/Set9, GST-tag (E. coli-derived) | 100 ug | View |
| Set8, Active, GST-tag | 50 ug | View |
| SetDB1, His-GST-tags | 20 ug | View |
| WDR5, FLAG-tag | 100 ug | View |
| WDR5, His-tag | 100 ug | View |
| Name | Packsize | Order |
|---|---|---|
| 400 uM S-Adenosylmethionine | 250 ul | View |
| Histone H2a|Full Length|Biotin-labeled|His-tag Recombinant | 0.5 mg | View |
| Histone H2a|Full Length|Biotin-labeled|His-tag Recombinant | 50 ug | View |
| Histone H2a|Full Length|His-tag Recombinant | 1 mg | View |
| Histone H2a|Full Length|His-tag Recombinant | 100 ug | View |
| Histone H2b|Full Length|His-tag Recombinant | 1 mg | View |
| Histone H2b|Full Length|His-tag Recombinant | 100 ug | View |
| Histone H3 (2-58)|GST-tag Recombinant | 500 ug | View |
| Histone H3 (K27M)|His-tag Recombinant | 100 ug | View |
| Histone H3 K27C|Full Length|His-tag Recombinant | 100 ug | View |
| Histone H3 Peptide (21-44), Monomethyl K27, Biotin-labeled | 40 nmole | View |
| Histone H3 Recombinant | 1 mg | View |
| Histone H3 Recombinant | 100 ug | View |
| Histone H3 peptide (1-21) | 160 nmol | View |
| Histone H3 peptide (1-21), Biotin-labeled | 80 nmole | View |
| Histone H3 peptide (21-44) | 160 nmol | View |
| Histone H3 peptide (21-44), Biotin-labeled | 80 nmole | View |
| Histone H3-H4 Tetramer H3K27C Unmodified|His-tag Recombinant | 50 ug | View |
| Histone H3/H4 Tetramer (full length)|His-tag Recombinant | 100 ug | View |
| Histone H3/H4 Tetramer (full length)|His-tag Recombinant | 50 ug | View |
| Histone H3|Full Length|Biotin-labeled|His-tag | 0.5 mg | View |
| Histone H3|Full Length|Biotin-labeled|His-tag | 50 ug | View |
| Histone H3|Full Length|His-tag Recombinant | 1 mg | View |
| Histone H3|Full Length|His-tag Recombinant | 100 ug | View |
| Histone H4 (2-58)|GST-tag Recombinant | 500 ug | View |
| Histone H4 Peptide (1-23), Monomethyl R3, Biotin-labeled | 40 nmole | View |
| Histone H4 peptide (1-21) | 160 nmol | View |
| Histone H4 peptide (1-21), Dimethyl R3, Biotin-labeled | 500 ul | View |
| Histone H4|Full Length|His-tag Recombinant | 1 mg | View |
| Histone H4|Full Length|His-tag Recombinant | 100 ug | View |
| Histone Octamer (Full length) Recombinant | 100 ug | View |
| Histone Octamer (full length)|His-tag Recombinant | 100 ug | View |
| Histone Octamer H3K27C Unmodified|His-tag Recombinant | 50 ug | View |
| Histone Octamer|Biotin-labeled|His-tag Recombinant | 50 ug | View |
| Native Core Histone Octamers | 0.6 mg | View |
| Native Nucleosome (HeLa-derived) | 0.6 mg | View |
| Native nucleosome (HEK293-derived) | 0.6 mg | View |
| PRMT4 peptide substrate|Biotin-labeled | 80 nmol | View |
| Recombinant Nucleosome (E. coli-derived) | 100 ug | View |
| Recombinant Nucleosome (E. coli-derived)|Biotin-labeled|His-Tag | 20 ug | View |
| S-adenosyl homocysteine | 250 ul | View |
| Name | Packsize | Order |
|---|---|---|
| 4x Detection Buffer 1 | 10 ml | View |
| 4x HDM Assay Buffer 1 | 10 ml | View |
| 4x HDM Assay Buffer 2 | 10 ml | View |
| 4x HDM Assay Buffer 3 | 10 ml | View |
| 4x HDM Assay Buffer 4 | 10 ml | View |
| 4x HDM Incomplete Assay Buffer | 10 ml | View |
| ALKBH5 Chemiluminescent Assay Kit | 96 reactions | View |
| FBXL10 (KDM2B) Chemiluminescent Assay Kit | 96 reactions | View |
| FTO Chemiluminescent Assay Kit | 96 reactions | View |
| JARID1A (KDM5A) Chemiluminescent Assay Kit | 96 reactions | View |
| JARID1B (KDM5B) Chemiluminescent Assay Kit | 96 reactions | View |
| JARID1B (KDM5B) TR-FRET Assay Kit | 384 reactions | View |
| JHDM1D (KDM7A) Chemiluminescent Assay Kit | 96 reactions | View |
| JMJD1A Homogeneous Assay Kit | 96 reactions | View |
| JMJD2A (KDM4A) Homogeneous Assay Kit | 384 reactions | View |
| JMJD2C (KDM4C) Chemiluminescent Assay Kit | 96 reactions | View |
| JMJD2D (KDM4D) Chemiluminescent Assay Kit | 96 reactions | View |
| JMJD3 (KDM6B) Chemiluminescent Assay Kit | 96 reactions | View |
| LSD1 (KDM1A) Chemiluminescent Assay Kit | 96 reactions | View |
| LSD1 (KDM1A) Homogeneous Assay Kit | 384 reactions | View |
| LSD2(KDM1B) Homogeneous Assay Kit (Dimethyl) | 384 reactions | View |
| LSD2(KDM1B) Homogeneous Assay Kit (Monomethyl) | 384 reactions | View |
| TET1 Chemiluminescent Assay Kit | 96 reactions | View |
| TET2 Chemiluminescent Assay Kit | 96 reactions | View |
| UTX Chemiluminescent Assay Kit | 96 reactions | View |
| UTX(KDM6A) Homogeneous Assay Kit | 384 reactions | View |
| Name | Packsize | Order |
|---|---|---|
| ALKBH5, FLAG-Tag | 20 ug | View |
| FBXL10 (KDM2B, JHDM1B), FLAG-tag | 20 ug | View |
| FBXL11 (KDM2A, JHDM1A), FLAG-Avi-tags | 20 ug | View |
| FTO, His-Tag (Sf9 derived) | 20 ug | View |
| FTO, His-Tag | 100 ug | View |
| JARID1A (KDM5A), FLAG-tag | 20 ug | View |
| JARID1A (KDM5A), His-Avi-tags, FLAG-tag | 20 ug | View |
| JARID1B (KDM5B), Full Length, FLAG-tag | 20 ug | View |
| JARID1B (KDM5B, PLU-1), His-FLAG-tags | 20 ug | View |
| JARID1C(KDM5C), FLAG-tag | 20 ug | View |
| JHDM1D (KDM7A), FLAG-tag | 20 ug | View |
| JMJD1A (KDM3A), FLAG-tag | 20 ug | View |
| JMJD1B (KDM3B), FLAG-tag | 20 ug | View |
| JMJD2A(KDM4A) (1-350), His-tag | 100 ug | View |
| JMJD2B (KDM4B), GST-tag | 100 ug | View |
| JMJD2B(KDM4B) , FLAG-tag | 100 ug | View |
| JMJD2C(KDM4C), GST-tag | 100 ug | View |
| JMJD2D (KDM4D), GST-tag | 100 ug | View |
| JMJD2E (KDM4DL), GST-tag | 100 ug | View |
| JMJD3 (KDM6B), FLAG-tag | 20 ug | View |
| JMJD6, GST-tag | 20 ug | View |
| LSD1 (KDM1A), GST-tag, Variant 2 | 50 ug | View |
| LSD1 (KDM1A), Variant 2 | 50 ug | View |
| LSD2 (KDM1B), GST-Tev-Tag | 20 ug | View |
| Mouse JARID1B (KDM5B, PLU-1), FLAG-tag | 20 ug | View |
| PHF8 (KDM7B), (2-525), FLAG-tag | 20 ug | View |
| PHF8 (KDM7B), Full-length, FLAG-tag | 20 ug | View |
| TET1, FLAG-tag | 10 ug | View |
| TET1, FLAG-tag | 50 ug | View |
| TET2, FLAG-His-tag | 50 ug | View |
| TET2, FLAG-Tag, His-Tag (916-2002) | 50 ug | View |
| TET3, FLAG-Tag, His-Tag | 50 ug | View |
| UTX (KDM6A), C-term FLAG-tag | 20 ug | View |
| UTX (KDM6A), N-terminal FLAG-tag | 20 ug | View |
| Name | Packsize | Order |
|---|---|---|
| Biotinylated Histone H3 Peptide Substrate | 500 reactions | View |
| Blocking Buffer 4 (Multiple Epigenetics Assay Kits) | 50 ml | View |
| H3K4me2 Substrate | 500 ul | View |
| Histone H3 K27cMe1, Full Length, His-tag | 100 ug | View |
| Histone H3 K27cMe2, Full Length, His-tag | 100 ug | View |
| Histone H3 K27cMe3, Full Length, His-tag | 100 ug | View |
| Histone H3 peptide (1-21), Dimethyl K9, Biotin-labeled | 500 ul | View |
| Histone H3 peptide (1-21), Monomethyl K9, Biotin-labeled | 500 ul | View |
| Histone H3 peptide (1-21), Trimethyl K9, Biotin-labeled | 500 ul | View |
| Histone H3-H4 Tetramer H3K27cMe2, His-tag | 50 ug | View |
| Histone H3-H4 Tetramer H3k27cMe3, His-tag | 50 ug | View |
| Histone Octamer H3K27cMe2, His-tag | 50 ug | View |
| Histone Octamer H3K27cMe3, His-tag | 50 ug | View |
