Histone Methylation

Discover our collection of histone methylation research tools

Methyltransferases are enzymes that transfer a methyl group from S-adenosylmethionine (SAM) to their substrates. Methyltransferases can methylate lysines and arginines on histone side chains. Lysines may be mono-, di-, or trimethylated and arginines may be mono-, symmetrically or asymmetrically dimethylated. Each of these different ‘flavors’ of methylation can result in different chromatin conformations and gene expression levels.