Histone H4 (Di Methyl Lys21) Rabbit Polyclonal Antibody

Product Code
Order Support
Shipping Information
Product Updates
  • Keep up to date with product offers, resources and news

  • Sign up

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin|limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation|DNA repair|DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones|also called histone code|and nucleosome remodeling.|PTM:Acetylation at Lys-6|Lys-9|Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.|PTM:Citrullination at Arg-4 by PADI4 impairs methylation.|PTM:Monomethylated|dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.|PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.|PTM:Sumoylated|which is associated with transcriptional repression.|PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.|Belongs to the histone H4 family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A|H2B|H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|
More Information
SKU AMS.BT-AP10436-100ul
Size 100 ul
Host species Rabbit
isotype IgG
Application WB, ELISA
Species reactivity Human, Mouse, Rat
Gene synonyms Histone H4 ;Di Methyl Lys21; Histone H4
Storage -20C for 1 year