HIF-1 alpha (Acetyl Lys532) Rabbit Polyclonal Antibody

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Contains two independent C-terminal transactivation domains|NTAD and CTAD|which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).|Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes|including|erythropoietin|glucose transporters|glycolytic enzymes|vascular endothelial growth factor|and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization|tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-
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SKU AMS.BT-AP10397-100ul
Size 100 ul
Host species Rabbit
isotype IgG
Application WB, ELISA
Species reactivity Human, Mouse, Rat
Gene synonyms HIF-1alpha ;Acetyl Lys532; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain-containing protein 8
Storage -20C for 1 year