Heparinase

Enzymatic degradation for heparin and/or heparan sulfate

We provide heparinase enzymes (heparin lyase enzymes) isolated from natural strains of Flavobacterium heparinum. The specialised method of preparation produces exceptionally pure individual enzyme species by providing baseline separation between the three heparinases.

What We Offer

Heparinase I

EC 4.2.2.7
Degrades heparin and the S-domains of heparan sulfate.
Catalyses the eliminative scission of the glycosidic linkage between N-sulfated glucosamine (GlcNSO₃) and 2-O-sulfated iduronic acid (IdoA,2SO₃). The IdoA,2SO₃residue is essential for the activity of Heparinase I while 6-O-sulfation of GlcNSO₃ enhances enzyme activity.

Find your Heparinase I

Product Information Table

Name	Datasheet	Packsize	Order
Heparinase I (EC 4.2.2.7) from Flavobacterium heparinum, 2 IU		2 IU	View
Heparinase I (EC 4.2.2.7) from Flavobacterium heparinum, 20 IU	-	20 IU	View
Heparinase I (EC 4.2.2.7) from Flavobacterium heparinum, 200 IU	-	200 IU	View
Heparinase I (EC 4.2.2.7) from Flavobacterium heparinum, 5 IU		5 IU	View
Heparinase I (EC 4.2.2.7) from Flavobacterium heparinum, 50 IU	-	50 IU	View

Heparinase II

EC number not assigned
Degrades heparin and heparan sulfate
Catalyses the eliminative scission of the glycosidic linkages between N-sulfated or N-acetylated glucosamine and glucuronic or iduronic acid. This is a broad activity enzyme that tolerates O-sulfation of the uronic acid and glucosamine residues.

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Product Information Table

Name	Packsize	Order
Heparinase II from Flavobacterium heparinum, 0.2 IU	0.2IU	View
Heparinase II from Flavobacterium heparinum, 1 IU	1 IU	View
Heparinase II from Flavobacterium heparinum, 2 IU	2 IU	View
Heparinase II from Flavobacterium heparinum, 20 IU	20 IU	View

Heparinase III

EC 4.2.2.8
Degrades heparan sulfate (HS)
Catalyses the eliminative scission of glycosidic linkages between N-sulfated or N-acetylated glucosamine (GlcNSO₃or GlcNAc) and glucuronic acid (GlcA)

Find your Heparinase III

The investigation of viral entry receptors in lung organoids, such as heparan sulfate stained with AMSBIO α-heparan sulfate antibody (clone F58-10E4), allowed us to compare our model to adult human lung and discuss viral entry mechanisms. Importantly, AMSBIO also provides Heparinase III for enzymatic digest of the glycan receptor as negative staining control, which allows for an adequate staining control of improved quality compared to ‘primary ab only’ controls in challenging glycan receptor stains.

Helena Meyer-Berg (University of Oxford, UK)

Product Information Table

Name	Datasheet	Packsize	Order
Heparinase III (EC 4.2.2.8) from Flavobacterium heparinum, 0.5 IU		0.5 IU	View
Heparinase III (EC 4.2.2.8) from Flavobacterium heparinum, 1 IU		1 IU	View
Heparinase III (EC 4.2.2.8) from Flavobacterium heparinum, 2 IU		2 IU	View
Heparinase III (EC 4.2.2.8) from Flavobacterium heparinum, 20 IU	-	20 IU	View
Heparinase III (EC 4.2.2.8) from Flavobacterium heparinum, 5 IU		5 IU	View
Heparinase III (EC 4.2.2.8) from Flavobacterium heparinum, 50 IU	-	50 IU	View
Heparinase III (Heparitinase I) Flavobacterium heparinum (EC 4.2.2.8), 0.1 IU	-	0.1 IU	View

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Heparinase

Enzymatic degradation for heparin and/or heparan sulfate

What We Offer

Heparinase I

Product Information Table

Heparinase II

Product Information Table

Heparinase III

Product Information Table

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