Fc Receptor Proteins
Accelerate your mAb development
The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. AMSBIO offers a comprehensive collection of recombinant Fc receptor proteins, including their common variants to help expedite your monoclonal antibody development. A combination of high quality and the maintenance of binding activity makes these proteins an invaluable tool in immunology research.
See all Fc Receptor Proteins
- Produced in HEK293 cells- ensures they possess the authentic posttranslational modifications essential for binding.
- High purity & quality- all proteins undergo analysis via SDS-PAGE and HPLC prior to launch.
- Binding activity validated by both SPR and ELISA analyses prior to launch.
- Biotinylated Fc receptors available
Importance of Fc Receptors in research
The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half life, while that between the Fc fragment and FCGRIIIA (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Hence, screening for desired binding affinity to these Fc receptors is an essential component in the development of a therapeutic mAb (monoclonal antibody).